Preparation and characterization of ibuprofen microspheres

Abstract

Ibuprofen was microencapsulated with Eudragit RS using an o/w emulsion solvent evaporation technique. The effects of three formulation variables including the drug:polymer ratio, emulsifier (polyvinyl alcohol) concentration and organic solvent (chloroform) volume on the entrapment efficiency and microspheres size distribution were examined. The drug release rate from prepared microspheres and the release kinetics were also studied. The results demonstrated that microspheres with good range of particle size can be prepared, depending on the formulation components. The drug:polymer ratio had a considerable effect on the entrapment efficiency. However, particle size distribution of microspheres was more dependent on the volume of chloroform and polyvinyl alcohol concentration rather than the drug:polymer ratio. The drug release pattern showed a burst effect for all prepared microspheres due to the presence of uncovered drug crystals on the surface. It was shown that the release profiles of all formulations showed good correlation with the Higuchi model of release.

Formulation and In vitro Evaluation of Eudragit RL 100 Loaded Fexofenadine HCl Microspheres

“…Solvent evaporation method simply engages emulsification of a solution containing polymer and drug with an additional medium in which the drug and polymer cannot dissolve. This method has been used to prepare microcapsules of a variety of compounds using several different polymeric materials (Bakan, 1986;Bolourtchian, 2005) Fexofenadine HCl (FFN) is a second-generation nonsedating histamine H1 receptor antagonist. As it is included in class III of the biopharmaceutical classification system (BCS), polymers can be used to prolong its duration of action in body, thereby increasing the bioavailability (Gundogdu and Karasulu, 2011).…”

Novel modified release tableted microspheres of ibuprofen and misoprostol in a combined formulation: Use of software DDSolver

“…Micro encapsulation techniques have been employed to make sustained drug delivery system of IBN (Pralhad and Rajendrakumar, 2004;Perumal, 2001;Valot et al, 2009;Aerts et al, 2010;Bolourtchian et al, 2005). Similarly, different methods have also been employed to prepare stable and sustained drug delivery system of MIS (Oth et al, 1992).…”

“…It is a useful method of prolonging drug release from dosage forms and reducing adverse effects (Bolourtchian et al, 2005). Controlled drug delivery systems in comparison to immediate drug delivery systems offer desired concentration of drugs at the absorption site allowing maintenance of drug concentration within the therapeutic range, lowering frequency of drug administration and thus, enhancing patient compliance (Wahab et al, 2011).…”

Design and Development of Sustained Release Microspheres of Ibuprofen by Emulsification Solvent Evaporation Method Using Polymeric Blend

“…The common emulsion system used oil-in-water (o/w), with microspheres being produced by the emulsion solvent evaporation method. This relatively simple method enables the entrapment of a wide range of hydrophobic drugs (Abbaspour et al, 2008;Bolourtchian et al, 2005) The main objective of this work was to investigate the possibility of obtaining a sustained release formulation of Ibuprofen microspheres by using Eudragit RSPO and Methocel K4M in various drugs, polymer ratios. The various physicochemical characteristics and the in-vitro release rates from these microspheres were thus examined (Wan et al, 1995, Yamuda et al, 2001).…”