Preparation and Characterization of Inulin Coated Gold Nanoparticles for Selective Delivery of Doxorubicin to Breast Cancer Cells

Licciardi, Mariano; Volsi, Anna Li; Mauro, Nicolò; Scialabba, Cinzia; Cavallaro, Gennara; Giammona, Gaetano

doi:10.1155/2016/2078315

Cited by 21 publications

(12 citation statements)

References 31 publications

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“…Using MTT assay, the authors determined that the cytotoxicity of these nanoplatforms, made of Au NPs loaded with 5 μL of Dox, was higher in the case of cancer cells when compared to normal cells, making them a potential candidate for cancer treatment [ 183 ]. Similar results were obtained by Licciardi et al who relied on spherical Au NPs conjugated with inulin folate (INU-FA) and loaded with Dox to treat breast cancer cells [ 184 ].…”

Section: Applications Of Photochemically Produced Ag Nps and Au Npssupporting

confidence: 84%

Photochemical Synthesis of Gold and Silver Nanoparticles—A Review

et al. 2021

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Nanomaterials have supported important technological advances due to their unique properties and their applicability in various fields, such as biomedicine, catalysis, environment, energy, and electronics. This has triggered a tremendous increase in their demand. In turn, materials scientists have sought facile methods to produce nanomaterials of desired features, i.e., morphology, composition, colloidal stability, and surface chemistry, as these determine the targeted application. The advent of photoprocesses has enabled the easy, fast, scalable, and cost- and energy-effective production of metallic nanoparticles of controlled properties without the use of harmful reagents or sophisticated equipment. Herein, we overview the synthesis of gold and silver nanoparticles via photochemical routes. We extensively discuss the effect of varying the experimental parameters, such as the pH, exposure time, and source of irradiation, the use or not of reductants and surfactants, reagents’ nature and concentration, on the outcomes of these noble nanoparticles, namely, their size, shape, and colloidal stability. The hypothetical mechanisms that govern these green processes are discussed whenever available. Finally, we mention their applications and insights for future developments.

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Section: Applications Of Photochemically Produced Ag Nps and Au Npssupporting

confidence: 84%

Photochemical Synthesis of Gold and Silver Nanoparticles—A Review

et al. 2021

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“…The use of folic acid as a ligand can also offer the specific targeting capability for the inulin derivative towards tumor cells. This strategy was exploited by Licciardi et al [ 196 ]. Modified inulin derivative acted as a coating agent for gold nanoparticles loaded with DOX and functionalized with folic acid ligand to achieve targeted and selective delivery to MCF7 cancer cells.…”

Section: Inulin Drug Delivery Systemsmentioning

confidence: 99%

Inulin and Its Application in Drug Delivery

et al. 2021

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Inulin’s unique and flexible structure, stabilization/protective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. This, in turn, helps in increasing bioavailability, improving cellular uptake, and achieving targeted, sustained, and controlled release of drugs and biomolecules. This review focuses on the various types of inulin drug delivery systems such as hydrogel, conjugates, nanoparticles, microparticles, micelles, liposomes, complexes, prodrugs, and solid dispersion. The preparation and applications of the different inulin drug delivery systems are further discussed. This work highlights the fact that modification of inulin allows the use of this polymer as multifunctional scaffolds for different drug delivery systems.

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“…The capacity of TDF binding to MNP@Au nanostars was calculated to be 23 µg TDF / mg nanostars (10.4% binding efficiency) after 1 h reaction. Gold is known to have high affinity with amine groups 49,50 . It is expected that the primary amine in TDF promoted the binding of TDF to MNP@Au nanostars.…”

Section: Drug Binding Assessment and Nir-triggered Drug Release An Amentioning

confidence: 99%

Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery

Tomitaka

Arami

Ahmadivand

et al. 2020

Sci Rep

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Smart multifunctional nanoparticles with magnetic and plasmonic properties assembled on a single nanoplatform are promising for various biomedical applications. Owing to their expanding imaging and therapeutic capabilities in response to external stimuli, they have been explored for on-demand drug delivery, image-guided drug delivery, and simultaneous diagnostic and therapeutic (i.e. theranostic) applications. In this study, we engineered nanoparticles with unique morphology consisting of a superparamagnetic iron oxide core and star-shaped plasmonic shell with high-aspect-ratio gold branches. Strong magnetic and near-infrared (NIR)-responsive plasmonic properties of the engineered nanostars enabled multimodal quantitative imaging combining advantageous functions of magnetic resonance imaging (MRI), magnetic particle imaging (MPI), photoacoustic imaging (PAI), and image-guided drug delivery with a tunable drug release capacity. The model drug molecules bound to the core-shell nanostars were released upon NIR illumination due to the heat generation from the core-shell nanostars. Moreover, our simulation analysis showed that the specific design of the core-shell nanostars demonstrated a pronounced multipolar plasmon resonance, which has not been observed in previous reports. The multimodal imaging and NIR-triggered drug release capabilities of the proposed nanoplatform verify their potential for precise and controllable drug release with different applications in personalized medicine.

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Preparation and Characterization of Inulin Coated Gold Nanoparticles for Selective Delivery of Doxorubicin to Breast Cancer Cells

Cited by 21 publications

References 31 publications

Photochemical Synthesis of Gold and Silver Nanoparticles—A Review

Photochemical Synthesis of Gold and Silver Nanoparticles—A Review

Inulin and Its Application in Drug Delivery

Magneto-plasmonic nanostars for image-guided and NIR-triggered drug delivery

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