Preparation and characterization of iron/β-tricalcium phosphate bio-cermets for load-bearing bone substitutes

He, Fupo; Qian, Guowen; Ren, Weiwei; Ke, Jinhuan; Fan, Peirong; Shi, Xuetao; Cheng, Yong; Wu, Shanghua; Deng, Xin; Ye, Jiandong

doi:10.1016/j.ceramint.2017.03.173

Cited by 18 publications

(7 citation statements)

References 36 publications

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“…This increase may be attributed to the hydrophilicity, and thus the gradual swelling dynamics, of PU (60 wt %) as reported by the manufacturer. OPN primers 31 and OCN primers 39 were run alongside GAPDH primers for 40 cycles with a denaturing phase of 95 °C for 15 s, an annealing phase of 55 °C for 1 min, and an extending phase of 72 °C for 1 min after an initial activation phase of 95 °C for 10 min. A proceeding dissociation cycle of 95 °C for 1 min, 55 °C for 30 s, and 95 °C for 5 min was used to determine primer efficiency.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold

Bow

Newby

Rifkin

et al. 2019

ACS Appl. Bio Mater.

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The complex dynamic nature of bone tissue presents a unique challenge for developing optimal biomaterials within the field of bone tissue engineering. Materials based on biological and physiological characteristics of natural bone have shown promise for inducing and promoting effective bone repair. Design of multicomposite scaffolds that incorporate both malleable and hard mineral components allows for intricate structures with nano- and macrosized mineral components to provide architectural elements that promote osteogenesis. The examined S-1 and S-2 scaffolds are multilayered constructs which differ only in the compositional ratio of nanohydroxyapatite (nHA) and decellularized bone particles (DBPs). The constructs incorporated previously studied nHA/polyurethane films interspersed with macrosized bone DBPs to stimulate integration with native tissue and induce osteogenic activity. In vitro assessment of cytocompatibility and osteostimulatory characteristics indicated that the scaffolds did not negatively impact cell health and demonstrated osteogenic effects. When the constructs were implanted in vivo, in a rat tibial defect model, the biocompatibility and osteogenic impact were confirmed. Material-treated defects were observed to not induce negative tissue reactions and, in those treated with S-1 scaffolds, exhibited greater levels of new bone formation. These results indicate that, while both scaffold designs were biocompatible, S-1 constructs demonstrate more effective biologically relevant nano-/macromineral architectural elements.

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Section: Resultsmentioning

confidence: 99%

Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold

Bow

Newby

Rifkin

et al. 2019

ACS Appl. Bio Mater.

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“…As presented in Fig. 7, the incorporation of Nb or Nb-Ag [128] could effectively enhance the mechanical strength and fracture toughness to pure HA. The in vitro and in vivo results revealed that the incorporation of Nb could promote osteoblast proliferation, as well as osteogenic differentiation and osteointegration ability of the biocermets.…”

Section: Spark Plasma Sinteringmentioning

confidence: 88%

“…He et al [128] reported β-TCP-Fe biocermet prepared via cold isostatic pressing at room temperature under a pressure of 200 MPa with a holding time of 2 min, followed by high heat sintering. The X-ray diffraction pattern and corresponding calculated lattice parameters demonstrated that atomic diffusion occurred between the Fe and β-TCP matrix during the sintering process, which could form a strong bonding to benefit the interface between β-TCP and Fe.…”

Section: Isostatic Pressingmentioning

confidence: 99%

“…They found that the proliferation and early-differentiation stages of pre-osteoblasts cells were considerably improved after the addition of Ti, which thereby improved the cytocompatibility of Al 2 O 3 . He et al [128] evaluated cell activity of β-TCP-Fe biocermet by using mouse bone mesenchymal stem cells (mBMSCs), the result of showed that the biocermet was cytocompatible and bone-related gene expression of mBMSCs was up-regulated by the released Fe ions. In addition, Swain et al [71] introduced Fe-Mg into β-TCP-based biocermets and evaluated the in vitro biological performances using osteoblast and endothelial cells.…”

Section: Biological Properties Of Biocermetsmentioning

confidence: 99%

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Advances in biocermets for bone implant applications

et al. 2020

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As two promising biomaterials for bone implants, biomedical metals have favorable mechanical properties and good machinability but lack of bioactivity; while bioceramics are known for good biocompatibility or even bioactivity but limited by their high brittleness. Biocermets, a kind of composites composing of bioceramics and biomedical metals, have been developed as an effective solution by combining their complementary advantages. This paper focused on the recently studied biocermets for bone implant applications. Concretely, biocermets were divided into ceramic-based biocermets and metal-based biocermets according to the phase percentages. Their characteristics were systematically summarized, and the fabrication methods for biocermets were reviewed and compared. Emphases were put on the interactions between bioceramics and biomedical metals, as well as the performance improvement mechanisms. More importantly, the main methods for the interfacial reinforcing were summarized, and the corresponding interfacial reinforcing mechanisms were discussed. In addition, the in vitro and in vivo biological performances of biocermets were also reviewed. Finally, future research directions were proposed on the advancement in component design, interfacial reinforcing and forming mechanisms for the fabrication of high-performance biocermets.

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“…Among them, Fe is recognized as the preferable choice to provide structure support for the defect bone in load-bearing area due to its excellent mechanical properties [5,6]. Meanwhile, Fe is one of the essential nutritional elements, and involves a variety of oxidases and metabolic enzymes [7,8]. Its favorable biocompatibility has also been confirmed by in vitro and in vivo research [9,10].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Carbon as Galvanic-Corrosion Activator Accelerates Fe Degradation

Shuai

Deng

et al. 2020

Applied Sciences

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Iron (Fe) has attracted intensive attention as a bone implant material because of its inherent biodegradability, favorable biocompatibility and mechanical properties. Nevertheless, it degrades too slowly in a physiological environment, which limits its further clinical application. In this work, mesoporous carbon (MC) was introduced into Fe bone implant manufactured via a laser-additive manufacturing process. Particularly, MC possesses a noble standard corrosion potential and excellent electrical conductivity, thus acting as an effective cathode and activating micro-galvanic corrosion in the Fe matrix. More importantly, its high specific surface area enhanced the area ratio between cathode and anode, which further enhanced the galvanic corrosion effect. As a consequence, the corrosion rate was enhanced from 0.09 to 0.24 mm/year based on immersion tests. Besides, Fe/MC composite exhibited good cytocompatibility, as well as excellent mechanical properties. The positive results proved that the Fe/MC composite shows great potential as a bone implant.

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Preparation and characterization of iron/β-tricalcium phosphate bio-cermets for load-bearing bone substitutes

Cited by 18 publications

References 36 publications

Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold

Evaluation of a Polyurethane Platform for Delivery of Nanohydroxyapatite and Decellularized Bone Particles in a Porous Three-Dimensional Scaffold

Advances in biocermets for bone implant applications

Mesoporous Carbon as Galvanic-Corrosion Activator Accelerates Fe Degradation

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