Preparation and Characterization of Isoniazid Chitosan Loaded Nanoparticles

Sharma, Prashansa; Sharma, Pramod Kumar; Mishra, Vidya Bhushan; Bhandari, Akanksha

doi:10.22270/jddt.v4i5.972

Cited by 9 publications

(8 citation statements)

References 10 publications

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“…To emulsify the medication, a combination of oils and triglycerides may be employed. A number of synthetic lipids, such as Caproyl 90, triacetin, isopropyl myristate, oleic acid, palm oil esters, corn oil, olive oil, isopropyl palmitate, LabrafilMM44CS, Maisine 35-1, Miglyol 812, Captex 200, Captex 355, and Captex 8000, are often used in the production of nanoemulsions [ 11 – 13 ].…”

Section: Components Of Nanoemulsionmentioning

confidence: 99%

Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs

Preeti,

Sambhakar,

Malik

et al. 2023

Scientifica

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The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally between 20 and 200 nanometers, creates a significant interfacial area for drug dissolution, improving the solubility and bioavailability of drugs that are weakly water-soluble. Additionally, nanoemulsions are a flexible platform for drug administration across various therapeutic areas since they can encapsulate hydrophilic and hydrophobic medicines. Nanoemulsion can be formulated in multiple dosage forms, for example, gels, creams, foams, aerosols, and sprays by using low-cost standard operative processes and also be taken orally, topically, topically, intravenously, intrapulmonary, intranasally, and intraocularly. The article explores nanoemulsion formulation and production methods, emphasizing the role of surfactants and cosurfactants in creating stable formulations. In order to customize nanoemulsions to particular medication delivery requirements, the choice of components and production techniques is crucial in assuring the stability and efficacy of the finished product. Nanoemulsions are a cutting-edge technology with a lot of potential for improving medication bioavailability in a variety of therapeutic contexts. They are a useful tool in the creation of innovative pharmaceutical formulations due to their capacity to enhance drug solubility, stability, and delivery. Nanoemulsions are positioned to play a crucial role in boosting medication delivery and enhancing patient outcomes as this field of study continues to advance.

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Section: Components Of Nanoemulsionmentioning

confidence: 99%

Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs

Preeti,

Sambhakar,

Malik

et al. 2023

Scientifica

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“…Once a new action film is formed, the active agent molecules stabilize and protect in two ways: by reducing interfacial tension and by forming a protective layer to prevent droplet aggregation (Kuhn & Cunha, 2012). However, according to Sharma et al (2013), high-pressure homogenization is only suitable for the preparation of O/W emulsions with less than 20% oil phase content. When it comes to the formulation of highly viscous or creamy emulsions with an average droplet diameter of less than 200 nm, high-pressure homogenization is not applicable.…”

Section: High-pressure Homogenizationmentioning

confidence: 99%

Emulsion and its application in the food field: An update review

Wang

et al. 2023

eFood

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Natural emulsifier‐stabilized emulsions have garnered a significant amount of attention in many industries including foods, pharmaceuticals, cosmetics, health care formulations, paints, polymer blends and oils. Various methods have been used to improve the bioavailability of functional substances, such as microemulsions, nanoemulsions, Pickering emulsions, and complexes. Over recent years, emulsions have been increasingly investigated due to their potential as drug‐delivery vehicles for a wide range of application. In this review, we discuss some recent publications in the area of various emulsions in the food filed, detailed analysis of the mechanisms for different methods of preparation, compared with the different composition conditions on the stability. In addition, the above conditions affect the properties of the emulsions, but also affect functional activity. According to the current research status, some suggestions are put forward for further study.

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“…Nanoemulsões são exemplos de nanomateriais, por serem constituídas por uma fase oleosa, fase aquosa e um agente surfactante que, juntos, formam gotículas na escala nanométrica 107,108 . Devido à capacidade de a nanoemulsão se associar a diversos fármacos e direcioná-los às células-alvo, a eficácia do fármaco é aumentada, sendo a dose total necessária para o tratamento reduzida, diminuindo, assim, os efeitos colaterais 109 .…”

Section: C) Nanoemulsõesunclassified

“…Devido à capacidade de a nanoemulsão se associar a diversos fármacos e direcioná-los às células-alvo, a eficácia do fármaco é aumentada, sendo a dose total necessária para o tratamento reduzida, diminuindo, assim, os efeitos colaterais 109 . Além disso, a nanoemulsão diminui a exposição do fármaco às ações externas, como oxidação e hidrólise, preservando sua atividade 107,110 . Assim, o uso de nanoemulsões tem ganhado atenção, pois supera limitações apresentadas pela administração convencional de fármacos 111,112 .…”

Section: C) Nanoemulsõesunclassified