Preparation and Characterization of Liquefied Ibuprofen Using Self-Microemulsion Drug Delivery System (SMEDDS)

Ahn, Yong-San; Song, Ji-Hee; Kang, Bok-Ki; Kim, Moon-Suk; Cho, Sun-Hang; Rhee, John-M.; Lee, Hai-Bang; Khang, Gilson

doi:10.4333/kps.2004.34.1.035

Journal of Pharmaceutical Investigation

2004

DOI: 10.4333/kps.2004.34.1.035

|View full text |Cite

Preparation and Characterization of Liquefied Ibuprofen Using Self-Microemulsion Drug Delivery System (SMEDDS)

Yong-San Ahn¹,

Ji-Hee Song²,

Bok-Ki Kang³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2012

2023

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SMEDDS can improve the solubility and bioavailability of lipophilic drugs, reduce the frequency of administration, avoid first-pass metabolism, and bypass P-glycoprotein efflux [11] . Consequently, SMEDDS technology has been applied to a series of drugs, such as Ibuprofen [12] , Nintedanib [13] , and Tacrolimus [14] with enhanced absorption. In addition, SMEDDS has a controlled-release and targeting effect as a carrier, using SMEDDS, sugar [15] , sugar nanoparticles [16] , hyaluronic acid [17] , hydrogels, microspheres and micelles [18,19] as drug delivery carriers and surface modification, which greatly improved the targeting of drug delivery and had been widely used in liver targeting, brain targeting and lung targeting.…”

mentioning

confidence: 99%

Improving the Oral Absorption of Celecoxib via Solid Self-Microemulsion Drug Delivery System: Preparation and In Vitro/In Vivo Evaluation

Zhang,

Wu,

Feng

et al. 2023

IJPS

View full text Add to dashboard Cite

Improving the Oral Absorption of Celecoxib via Solid Self-Microemulsion Drug Delivery SystemCelecoxib is a specific cyclooxygenase-2 inhibitor with poor solubility and low bioavailability. A solid selfmicroemulsifying drug delivery system of celecoxib was therefore developed to improve in vitro drug solubility and in vivo absorption. Solubility testing, compatibility testing and pseudo-ternary phase diagrams were employed in the design. Morphological observation, droplet size and in vitro release were used to characterize the formulation. The optimized celecoxib-liquid self-microemulsifying drug delivery system was determined as 10 % of celecoxib, 25 % of medium chain triglycerides, 56.25 % of emulsifier and 18.75 % of Transcutol HP. 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay was used to investigate the cytoxicity of active pharmaceutical ingredients, blank self-microemulsion and celecoxib liquid self-microemulsifying drug delivery system on Caco-2 cells. Celecoxib solid self-microemulsifying drug delivery system was prepared with Neusilin-US2 as a solid adsorbent and characterized using scanning electron microscopy, X-ray, Fourier-transform infrared spectroscopy, differential scanning calorimetry and in vitro release. Celecoxib liquid self-microemulsifying drug delivery system had a clear and transparent light-yellow appearance with average particle size of about 22.68 nm, zeta potential of -31.92 mv, and polydisperse coefficient of 0.141. 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide results showed that the formulations virtually had no cytotoxic effect on the cells. The results also showed that celecoxib existed in an amorphous state in celecoxib-solid self-microemulsifying drug delivery system, and the celecoxib-liquid self-microemulsifying drug delivery system and celecoxib-solid-self-microemulsifying drug delivery system had a dissolution degree of more than 90 % in different media with good stability. The pharmacokinetic studies showed that the area under curve of the liquid self-microemulsifying drug delivery system and self-microemulsifying drug delivery system increased by 6.59 and 6.37 folds, respectively, compared with celecoxib suspension. The findings showed that the developed solid self-microemulsion formulations improved the bioavailability of the drug with no cytotoxicity, hence the formulation can serve as a promising carrier for the oral delivery of celecoxib.

show abstract

mentioning

confidence: 99%

Improving the Oral Absorption of Celecoxib via Solid Self-Microemulsion Drug Delivery System: Preparation and In Vitro/In Vivo Evaluation

Zhang,

Wu,

Feng

et al. 2023

IJPS

View full text Add to dashboard Cite

show abstract

Comparative Study of Ibuprofen Solubility in Synthetic and Natural Lipid Vehicles

Roni

Jalil

2012

Dhaka Univ. J. Pharm. Sci

View full text Add to dashboard Cite

show abstract

Degradation Properties of Ibuprofen Using Photocatalytic Process

Cai¹,

Na²,

Ahn³

et al. 2012

Journal of the Environmental Sciences

View full text Add to dashboard Cite

In this study, Ibuprofen (IBP) degradation by the photo catalytic process was investigated under various parameters, such as UV intensity, optimum dosage of TiO2, alkalinity, temperature and pH of bulk solution. The pseudo-first order degradation rate constants were in the order of 10 -1 to 10 -4 min -1 depending on each condition. The Photocatalytic IBP degradation rate increased with an increase in the applied UV power. At high UV intensity a high rate of tri-iodide (I3 -) ion formation was also observed. Moreover, in order to avoid the use of an excess catalyst, the optimum dosage of catalyst under the various UV intensities (30 and 40 W/L) was examined and ranged from approximately 0.1 gL -1 . The photo catalytic IBP degradation rate was changed depending on the alkalinity and temperature and pH in the aqueous solution. This study demonstrated the potential of photo catalytic IBP degradation under different conditions.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Preparation and Characterization of Liquefied Ibuprofen Using Self-Microemulsion Drug Delivery System (SMEDDS)

Cited by 3 publications

References 21 publications

Improving the Oral Absorption of Celecoxib via Solid Self-Microemulsion Drug Delivery System: Preparation and In Vitro/In Vivo Evaluation

Improving the Oral Absorption of Celecoxib via Solid Self-Microemulsion Drug Delivery System: Preparation and In Vitro/In Vivo Evaluation

Comparative Study of Ibuprofen Solubility in Synthetic and Natural Lipid Vehicles

Degradation Properties of Ibuprofen Using Photocatalytic Process

Contact Info

Product

Resources

About