Preparation and characterization of magnetic PEG-PEI-PLA-PEI-PEG/Fe3O4-PCL/DNA micelles for gene delivery into MCF-7 cells

Afrouz, Mehdi; Ahmadi-Nouraldinvand, Farnaz; Amani, Amin; Zahedian, Hoda; Arabnejad, Fatemeh; Yaghoubi, Hashem; Farshad, Omid; Farazi, Neda; Jalali, Atefeh; Eskanlou, Hadi

doi:10.1016/j.jddst.2022.104016

Cited by 14 publications

(9 citation statements)

References 53 publications

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“…Due to their potent capacity to chemisorbed low CO2 concentration from wet flue gas, aminefunctionalized porous materials have undergone the greatest research among these adsorbents (Gaikwad et al 2021, Alkadhem, Elgzoly and Onaizi 2020, Li et al 2022. Polymeric amines, such as polyethyleneimine (PEI), have been used to impregnate porous supports to create adsorbents (Afrouz et al 2023). Aminosilanes are grafted onto the pore surface and amine monomers are polymerized in place within the support pores (Qi, Fu and Giannelis 2014).…”

Section: Chemisorption Methodsmentioning

confidence: 99%

Advanced Indoor CO2 Capture Technologies: A Comprehensive Review and Future Perspectives

Yuan

Song

Yang

et al. 2023

Preprint

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The prevalence of indoor air pollution, primarily stemming from human activities, has led to increasing concerns regarding elevated CO2 concentrations in indoor environments. Prolonged exposure to such environments has been linked to reduced productivity, headaches, nausea, and more severe health risks, such as Sick Building Syndrome. Consequently, the development of efficient methods to reduce CO2 concentrations in indoor air is of utmost importance. This review offers a comprehensive analysis of cutting-edge indoor CO2 capture technologies, delving into the adsorption performance of solvents produced via various techniques. Our findings highlight the emergence of innovative materials that significantly enhance the indoor adsorption process; nevertheless, further investigation into reaction kinetics and stability remains imperative for continued progress. Among the methods assessed, Thermal Swing Adsorption and Wet Impregnation demonstrate superior suitability for indoor CO2 capture applications. Importantly, this review also emphasizes the potential of novel ventilation strategies, incorporating both internal ventilation and CO2 capture devices, to not only reduce indoor CO2 concentrations but also promote energy efficiency in buildings.

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Section: Chemisorption Methodsmentioning

confidence: 99%

Advanced Indoor CO2 Capture Technologies: A Comprehensive Review and Future Perspectives

Yuan

Song

Yang

et al. 2023

Preprint

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“…10,11 PEI has been chemically modified to produce new derivatives with differing architectures to further improve its properties. 12 Among them, many attempts have been made to modify low molecular weight (LMW) PEI by introducing hydrophilic and hydrophobic segments onto the PEI backbone to obtain high transfection efficiency. 13−16 LMW PEI displays relatively little toxicity on human cells, but it is not effective for transgene expression on its own, so that it has served as a good starting point for further modifications to design de novo delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Tuning the Potency of Farnesol-Modified Polyethylenimine with Polyanionic Trans-Booster to Enhance DNA Delivery

Rajendran,

Morales,

Meenakshi Sundaram

et al. 2024

ACS Biomater. Sci. Eng.

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Low molecular weight polyethylenimine (PEI) based lipopolymers become an attractive strategy to construct nonviral therapeutic carriers with promising transfection efficiency and minimal toxicity. Herein, this paper presents the design and synthesis of novel farnesol (Far) conjugated PEI, namely PEI1.2k-SA-Far7. The polymers had quick DNA complexation, effective DNA unpacking (dissociation), and cellular uptake abilities when complexed with plasmid DNA. However, they were unable to provide robust transfection in culture, indicating inability of Far grafting to improve the transfection efficacy significantly. To overcome this limitation, the commercially available polyanionic Trans-Booster additive, which is capable of displaying electrostatic interaction with PEI1.2k-SA-Far7, has been used to enhance the uptake of pDNA polyplexes and transgene expression. pDNA condensation was successfully achieved in the presence of the Trans-Booster with more stable polyplexes, and in vitro transfection efficacy of the polyplexes was improved to be comparable to that obtained with an established reference reagent. The PEI1.2k-SA-Far7/pDNA/Trans-Booster ternary complex exhibited good compatibility with cells and minimal hemolysis activity. This work demonstrates the exemplary potency of using additives in polyplexes and the potential of resultant ternary complexes for effective pDNA delivery.

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“…36 PEI is the most prominent and characterized polycation for gene and drug delivery. 37 PEI with primary, secondary, and tertiary amino groups has antibacterial properties and pHsensitive response groups. 38 However, poor biocompatibility and cytotoxicity of PEI polymers have limited their further applications in the medical field.…”

Section: ■ Introductionmentioning

confidence: 99%

“…PEI is the most prominent and characterized polycation for gene and drug delivery . PEI with primary, secondary, and tertiary amino groups has antibacterial properties and pH-sensitive response groups .…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Hosting a pH-Sensitive Prodrug: An In Silico Investigation of Graphene Oxide-Based Nanovehicle toward Cancer Therapy

Zaboli

Raissi

Hashemzadeh

et al. 2023

ACS Appl. Bio Mater.

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Prodrug and drug delivery systems are two effective strategies for improving the selectivity of chemotherapeutics. Herein, via molecular dynamics (MD) simulation and free energy calculation, the effectiveness of the graphene oxide (GO) decorated with the pH-sensitive prodrug (PD) molecules in cancer therapy is investigated. PEI–CA–DOX (prodrug) was loaded onto the GO surface, in which the hydrogen bonding and pi–pi stacking interactions play the main role in the stability of the GO–PD complex. Due to the strong interaction of GO and PD (about −800 kJ/mol), the GO–PD complex remains stable during the membrane penetration process. The obtained results confirm that GO is a suitable surface for hosting the prodrug and passing it through the membrane. Furthermore, the investigation of the release process shows that the PD can be released under acidic conditions. This phenomenon is due to the reduction of the contribution of electrostatic energy in the GO and PD interaction and the entry of water into the drug delivery system. Moreover, it is found that an external electrical field does not have much effect on drug release. Our results provide a deep understanding of the prodrug delivery systems, which helps the combination of nanocarriers and modified chemotherapy drugs in the future.

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Preparation and characterization of magnetic PEG-PEI-PLA-PEI-PEG/Fe3O4-PCL/DNA micelles for gene delivery into MCF-7 cells

Cited by 14 publications

References 53 publications

Advanced Indoor CO2 Capture Technologies: A Comprehensive Review and Future Perspectives

Advanced Indoor CO2 Capture Technologies: A Comprehensive Review and Future Perspectives

Tuning the Potency of Farnesol-Modified Polyethylenimine with Polyanionic Trans-Booster to Enhance DNA Delivery

Graphene Oxide Hosting a pH-Sensitive Prodrug: An In Silico Investigation of Graphene Oxide-Based Nanovehicle toward Cancer Therapy

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