Preparation and characterization of magnetic ferroscaffolds for tissue engineering

Hu, Shang Hsiu; Liu, Ting Yu; Tsai, Chia Hui; Chen, San‐Yuan

doi:10.1016/j.jmmm.2006.11.081

Cited by 48 publications

(21 citation statements)

References 6 publications

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“…To date, magnetic scaffolds were prepared by insertion of nonactive iron oxide nanoparticles to nonmagnetic scaffolds, eg, by dip-coating of porous collagen or hydroxyapatite scaffolds in aqueous ferrofluids containing iron oxide nanoparticles, 17,19 or by in situ development of iron oxide nanoparticles in hydrogels. 20,21 In contrast, our magnetic scaffolds were prepared by in situ interaction of magnetic thrombin-conjugated nanoparticles with fibrinogen.…”

Section: Resultsmentioning

confidence: 99%

“…For example, Bock et al 19 succeeded in transforming standard commercial scaffolds, made of hydroxyapatite-collagen and pure collagen, to magnetic scaffolds by dip-coating the scaffolds in aqueous ferrofluids containing iron oxide nanoparticles. Hu et al 20 and Sivudu et al 21 fabricated magnetic hydrogel scaffolds by in situ development of iron oxide nanoparticles in gelatin or polyacrylamide hydrogels, respectively. It has been suggested to use the magnetic properties of these scaffolds for monitoring the scaffolds after implantation by MRI or X-ray, and for reloading the scaffolds after implantation with bioactive agents, such as growth factors, stem cells, or other bioactive reagents that can be bound to magnetic iron oxide nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Ziv-Polat¹,

Skaat²,

Shahar³

et al. 2012

IJN

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Novel tissue-engineered magnetic fibrin hydrogel scaffolds were prepared by the interaction of thrombin-conjugated iron oxide magnetic nanoparticles with fibrinogen. In addition, stabilization of basal fibroblast growth factor (bFGF) was achieved by the covalent and physical conjugation of the growth factor to the magnetic nanoparticles. Adult nasal olfactory mucosa (NOM) cells were seeded in the transparent fibrin scaffolds in the absence or presence of the free or conjugated bFGF-iron oxide nanoparticles. The conjugated bFGF enhanced significantly the growth and differentiation of the NOM cells in the fibrin scaffolds, compared to the same or even five times higher concentration of the free bFGF. In the presence of the bFGFconjugated magnetic nanoparticles, the cultured NOM cells proliferated and formed a threedimensional interconnected network composed mainly of tapered bipolar cells. The magnetic properties of these matrices are due to the integration of the thrombin-and bFGF-conjugated magnetic nanoparticles within the scaffolds. The magnetic properties of these scaffolds may be used in future work for various applications, such as magnetic resonance visualization of the scaffolds after implantation and reloading the scaffolds via magnetic forces with bioactive agents, eg, growth factors bound to the iron oxide magnetic nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Ziv-Polat¹,

Skaat²,

Shahar³

et al. 2012

IJN

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“…Nanoparticles, especially magnetic ones, exhibit a very high tendency towards agglomeration. 3D porous materials functionalised with magnetic particles are generally obtained by way of immersion in a ferromagnetic liquid [1] with the use of co--precipitation methods [20], or using a variety of surfactants applied to the surface of the nanoparticles to prevent their agglomeration.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Polymer Nanocomposite for Medical Application

et al. 2014

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Magnetic sponges derived from biocompatible and resorbable polymers are promising materials for medical applications. These materials have been utilised extensively in research applications for the capture of biomolecules and cells, the construction of tissue scaolds and in regenerative medicine. The object of this study was a polymer scaold made of polycaprolactone (PCL) containing a 10 wt% amount of nanomagnetite, manufactured in a two-step method. The porosity and morphological parameters were characterised with the use of µ-computer--aided tomography and scanning electron microscopy. Furthermore, the magnetic properties were evaluated. The obtained results conrmed high porosity and the appearance of randomly oriented pores. Moreover, evaluations of the magnetic properties, of both the magnetite nanopowder and the prepared magnetic nanocomposite, were performed. The tests veried the ferromagnetic character of the materials under investigation.

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“…Hu et al (2007) were able to make magnetic ferroscaffolds by an in situ precipitation process in which iron oxide nanoparticles were co-precipitated and deposited within a gelatin hydrogel. 94 They also found that by increasing the amount of iron oxide nanoparticles inside the ferroscaffold, the magnetic properties of the scaffold were enhanced. Hernandez et al (2009) nanoparticles into a hydrogel composed of different polymers, such as poly(ethylene glycol) (PEG), poly(acrylamide) (PAAm) and polysaccharides, depending on the functional groups present on the nanoparticle surface.…”

Section: Synthesis Of Magneto-responsive Biomaterialsmentioning

confidence: 99%

Section: Synthesis Of Magneto-responsive Biomaterialsmentioning

confidence: 99%

Development of injectable, stimuli-responsive biomaterials as active scaffolds for applications in advanced drug delivery and osteochondral tissue regeneration

Adedoyin¹

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AcknowledgmentsFirst and foremost, I would like to thank my parents, Dr. John Akintayo Adedoyin and Dr.Omobola Adedoyin for their unconditional love, support and prayers. To my brothers, Dr.Ayodeji Adedoyin, and Mr. Akinola Adedoyin, thank you for your constant encouragement and advice. I owe much appreciation to my current and past lab mates -Meryem, Nandita, Ninad, Wei, Ted, Yang, Yue and Cristian. It has been a pleasure to work alongside you.To all my friends and adopted family at Northeastern, thank you for making my time here enjoyable and filled with wonderful memories. I would like to thank members of the Sridhar lab, specifically Dr. Rajiv Kumar, Codi Gharagouzloo, Bryce Delgado and Muizz Zaman, for their work in helping me with the synthesis and functionalization of the magnetic nanoparticles, developing the mathematical model of the force distribution within the nanocomposite scaffold, and the in vitro sustained drug release studies from the hydrogel that was done in collaboration with their lab. To my advisor, Dr. Adam K.Ekenseair, thank you for your leadership, wisdom and support during the past four and a half years. I also would like to thank my committee members, namely, Dr. Arthur Coury, Dr. Abigail Koppes, and Dr. Srinivas Sridhar for their guidance and mentorship. Lastly, thanks to the Chemical Engineering Community at NEU, without your support, none of this work would be possible. 3 AbstractOsteoarthritis (OA) is a degenerative joint disease that occurs when the cartilage matrix begins to breakdown. Every year, over 3.1 million surgeries are performed in an effort to treat damaged cartilage tissue. 4 Current treatment options such as osteochondral tissue grafting, micro-fracturing, and total knee replacements (TKRs) are effective in alleviating symptoms associated with OA, but often fail to promote the regeneration of normal cartilage. Therefore, due to the limitations of the current treatment options available, it has become necessary to develop better medical solutions to restore or regenerate cartilage tissue previously damaged by OA.Stimuli-responsive hydrogels, capable of exhibiting dramatic changes in swelling behavior, network structure, permeability and mechanical strength in response to changes in their local environment, have emerged as potential candidates as active scaffolds for several tissue engineering applications. Magneto-responsive biomaterials have become a subject of interest in the field of tissue engineering as their physical and structural properties could be manipulated spatiotemporally by varying the magnetic field strength, making them useful for applications in advanced drug delivery and osteochondral tissue regeneration. Thus, the goal of this thesis was to investigate the feasibility of developing an injectable, magneto-responsive hydrogel scaffold capable of delivering viable stem cell populations to a cartilage defect, and to spatiotemporally control the regeneration of the cartilage tissue in vivo.A magneto-responsive biomaterial was made by adding functional pa...

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Preparation and characterization of magnetic ferroscaffolds for tissue engineering

Cited by 48 publications

References 6 publications

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Magnetic Polymer Nanocomposite for Medical Application

Development of injectable, stimuli-responsive biomaterials as active scaffolds for applications in advanced drug delivery and osteochondral tissue regeneration

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