Preparation and Characterization of Microcapsules Encapsulating Octyl Methoxycinnamate by Complex Coacervation

Abstract

Zhao, et al.,: Octyl Methoxycinnamate-loaded MicrocapsulesThe aim of this study was to entrap the lipophilic ultraviolet absorber, octyl methoxycinnamate in microcapsuels to enhance its application. A complex coacervation method was established. Through the appearance of encapsulated glass beads prepared with different wall materials, gelatin and sodium polyphosphate were selected as wall materials because of dense structure and less adhesion. The effects of three variables, core/ (core+wall) ratio, pH at complex coacervation, and amount of cross-linking agent, on encapsulation efficiency were studied. Response surface methodology was employed to optimize the technology, and a polynomial regression model equation was generated. The optimization method enabled to predict the response variable value within the experimental range with good agreement between the predicted and experimental values. The microcapsules under the optimized conditions appeared spherical in shape with smooth nonporous surface and no tendency to aggregation. The photodegradation percentage of octyl methoxycinnamate after exposing to ultraviolet irradiation was determined and the transdermal permeation pattern of octyl methoxycinnamate and its photodegradation product from various formulations was estimated in vitro. From the results obtained, the microcapsules had achieved decreasing transdermal permeation of octyl methoxycinnamate and its photodegradation product, enhancing the accumulation of the sunscreen at the administration site, and then increasing the protection effect and safety. This study revealed the potential of sunscreen microcapsules as new skin drug delivery systems.

Microencapsulation of Vetiver Essential Oil using Complex Coacervation Technique

“…Higher temperatures than 60 o C were also tried but no microcapsules were formed on those temperatures. Similar observations were reported by Zhao et al (2016) and Sannapapamma et al (2018) that at The microcapsules formed at different ranges of initial and final pH were observed to determine the optimum pH values. It was found that microcapsules were formed only when the initial pH ranged from 4.0 to 5.5 and final pH ranged from 7.0 to 8.5.…”

Geraniol Encapsulated in Chitosan/Gum Arabic Nanoparticles: A Promising System for Pest Management in Sustainable Agriculture

“…In addition, the presence of geraniol decreased the temperature of the endothermic peak from 77 °C (without geraniol) to 70 °C (with geraniol). Decreases in the crystallinity temperature are indicative of structural changes in the chitosan . Therefore, the process of formation of the nanoparticles (cross-linking) appeared to have influenced the observed peaks.…”

“…Decreases in the crystallinity temperature are indicative of structural changes in the chitosan. 31 Therefore, the process of formation of the nanoparticles (cross-linking) appeared to have influenced the observed peaks. A lower temperature was observed for the nanoparticles containing GRL (Figure 4BIV), probably due to the interaction with the encapsulated hydrophobic component.…”