Preparation and characterization of MnII, CoII, NiII, CuII and ZnII kanamycin complexes

Mashaly, A.

doi:10.1016/s0277-5387(00)81754-4

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…These observed results, where the combinatorial treatments decreased the toxicity threshold of metal ion, could be due to the interactions between the metal ions and the antibiotics. It has been reported that kanamycin can form complexes with transition metal ions like Cu 2+ , and Zn 2+ (Mashaly, 1993 ) and therefore suggest that the Zn 2+ -kanamycin interactions are decreasing the toxicity effects of Zn 2+ on mammalian cells without disrupting their antimicrobial effect (Szczepanik et al, 2004 ; Shi et al, 2008 ).…”

Section: Discussionmentioning

confidence: 99%

Re-sensitizing Ampicillin and Kanamycin-Resistant E. coli and S. aureus Using Synergistic Metal Micronutrients-Antibiotic Combinations

Garza-Cervantes

Meza-Bustillos

Resendiz-Hernández

et al. 2020

Front. Bioeng. Biotechnol.

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Due to the recent emergence of multi-drug resistant strains, the development of novel antimicrobial agents has become a critical issue. The use of micronutrient transition metals is a promising approach to overcome this problem since these compounds exhibit significant toxicity at low concentrations in prokaryotic cells. In this work, we demonstrate that at concentrations lower than their minimal inhibitory concentrations and in combination with different antibiotics, it is possible to mitigate the barriers to employ metallic micronutrients as therapeutic agents. Here, we show that when administered as a combinatorial treatment, Cu 2+ , Zn 2+ , Co 2+ , Cd 2+ , and Ni 2+ increase susceptibility of Escherichia coli and Staphylococcus aureus to ampicillin and kanamycin. Furthermore, ampicillin-resistant E. coli is re-sensitized to ampicillin when the ampicillin is administered in combination with Cu 2+ , Cd 2+ , or Ni 2 . Similarly, Cu 2+ , Zn 2+ , or Cd 2+ re-sensitize kanamycin-resistant E. coli and S. aureus to kanamycin when administered in a combinatorial treatment with those transition metals. Here, we demonstrate that for both susceptible and resistant bacteria, transition-metal micronutrients, and antibiotics interact synergistically in combinatorial treatments and exhibit increased effects when compared to the treatment with the antibiotic alone. Moreover, in vitro and in vivo assays, using a murine topical infection model, showed no toxicological effects of either treatment at the administered concentrations. Lastly, we show that combinatorial treatments can clear a murine topical infection caused by an antibiotic-resistant strain. Altogether, these results suggest that antibiotic-metallic micronutrient combinatorial treatments will play an important role in future developments of antimicrobial agents and treatments against infections caused by both susceptible and resistant strains.

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Section: Discussionmentioning

confidence: 99%

Re-sensitizing Ampicillin and Kanamycin-Resistant E. coli and S. aureus Using Synergistic Metal Micronutrients-Antibiotic Combinations

Garza-Cervantes

Meza-Bustillos

Resendiz-Hernández

et al. 2020

Front. Bioeng. Biotechnol.

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“…1 Recent reports have also demonstrated specific and high affinity (mm) binding of aminoglycosides to RNA structural motifs. [2][3][4][5][6] Aminoglycoside complexes of metal ions have previously been reported, [7][8][9][10] however, the large positive charge density of the drug in neutral solution suggested to us that such molecules might prove to be efficient anion complexing agents. This work contrasts with earlier studies of anion binding that have focused on polyamine macrocycles including hexaaza ligands and porphyrin derivatives, [11][12][13][14] Novel advances in this chemistry should afford significant opportunities for the development of anion sensors, [15][16][17] and in separation science.…”

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confidence: 99%

Anion coordination by aminoglycosides: structural and charge effects

Ohyama¹,

Cowan²

1998

Chem. Commun.

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Über Hydroxygruppen an Platin(IV) koordinierte Kohlenhydrate ‐ eine neue Klasse von Platinkomplexen mit bioaktiven Liganden

Steinborn¹,

Junicke²,

Bruhn³

1997

Angewandte Chemie

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Nicht dissoziert sind die OH‐Gruppen, über die 1,2‐O‐Isopropyliden‐α‐D‐gluco‐ und ‐α‐D‐allofuranose in den ersten Kohlenhydrat‐Platin(IV)‐Komplexen an das Trimethylplatin‐Kation gebunden sind. Diese Komplexe sind zugleich die einzigen Platinkomplexe mit neutralen Kohlenhydratliganden ohne Ankergruppen. Rechts abgebildet ist die Struktur des Glucofuranosekomplex‐Kations [PtMe3(C9H16O6)]+.magnified image

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Preparation and characterization of MnII, CoII, NiII, CuII and ZnII kanamycin complexes

Cited by 10 publications

References 12 publications

Re-sensitizing Ampicillin and Kanamycin-Resistant E. coli and S. aureus Using Synergistic Metal Micronutrients-Antibiotic Combinations

Re-sensitizing Ampicillin and Kanamycin-Resistant E. coli and S. aureus Using Synergistic Metal Micronutrients-Antibiotic Combinations

Anion coordination by aminoglycosides: structural and charge effects

Über Hydroxygruppen an Platin(IV) koordinierte Kohlenhydrate ‐ eine neue Klasse von Platinkomplexen mit bioaktiven Liganden

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