Preparation and Characterization of Modified Nylon 66 Membrane for Blood Purification

Shakaib, M.; Ahmad, Iqbal; Yunus, Rosli Mohd; Noor, M. Z.

doi:10.1080/00914037.2013.769251

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Research on biomimicking membranes for biomedical applications such as blood purification, artificial organs, and other clinical medical devices is gaining impetus in the biomedical sector . With the advancement of research, artificial polymeric materials, such as cellulose acetate (CA), polyacrylonitrile (PAN), polysulfone (PSf), poly(ether sulfone) (PES), polyvinylidene fluoride (PVDF), polyvinyl chloride (PVC), nylon-66, polyurethane (PU), and polytetrafluoroethylene (PTFE), are being widely applied in various biomedical fields, namely hemodialysis, cardiopulmonary bypass, artificial oxygenators, plasma collection, etc.…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Nanocomposite Incorporated Poly(ether imide) Mixed Matrix Membranes for in Vitro Evaluation of Its Efficacy in Blood Purification Applications

Kaleekkal

Arumugham

Mohan

et al. 2015

Ind. Eng. Chem. Res.

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Hemodialysis is one of the most commonly used treatments for patients suffering from irrecoverable kidney damage. In our present work we investigate polyetherimide (PEI) mixed matrix membranes (MMMs) as a potential candidate for hemodialysis applications due to its efficient clearance and high biocompatibility. Graphene oxide (GO) was synthesized by the modified Hummers' method and was then confirmed by X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy and high resolution transmission electron microscopy. The GO-polyvinylpyrrolidone nano-composite incorporated PEI MMMs were fabricated by a semi-automatic casting unit, using the non-solvent induced phase separation (NIPS) technique. The effect of the nano-composite loading ratio was evaluated by water content; ultrafiltration rate, and porosity; which were all found to increase as the nano-composite content increased. Cross Sectional and top surface morphology was visualized using scanning electron microscopy and atomic force microscopy. The hydrophilicity of these membranes was in consonance with contact angle values. These MMMs demonstrated an increase in biocompatibility -reduced protein adsorption, suppressed platelet adhesion and lower complement activation. Furthermore the prolonged blood clotting time is an indication of the heparin mimic anticoagulant properties of these membranes. The cytocompatibility results by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay and live cell/dead cell staining indicated that there was an increase in cell viability. The membranes with 0.1 wt% GO showed an excellent clearance of the model uremic toxins, namely urea, vitamin B-12 and cytochrome-c in-vitro. The diffusive permeability of these membranes could be comparable to the existing commercial hemodialysis membranes. Thus it can be concluded that these membranes containing a composite of both functional nano-sheets and bioactive polymers have a tremendous potential to be utilized commercially in hemodialysis modules if shown successful in further in-vivo studies with an animal model.

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Section: Introductionmentioning

confidence: 99%

Graphene Oxide Nanocomposite Incorporated Poly(ether imide) Mixed Matrix Membranes for in Vitro Evaluation of Its Efficacy in Blood Purification Applications

Kaleekkal

Arumugham

Mohan

et al. 2015

Ind. Eng. Chem. Res.

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“…Compared to cellulose membranes, organic synthetic membranes possess more physical‐chemical advantages in terms of pore size, hydraulic permeability and filtration capacity . Polysulfone (PS) and polyethersulfone (PES) membranes are two of the most classical synthetic membranes, which have been widely used in clinical hemodialysis due to their excellent filtering properties and biocompatibility, thermal stability, mechanical strength, and chemical inertness.…”

Section: Microfluidic Hemodialysis Systems and Componentsmentioning

confidence: 99%

Recent Progress of Microfluidic Devices for Hemodialysis

Luo

Fan

Wang

2019

Small

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Microfluidic hemodialysis techniques have recently attracted great attention in the treatment of kidney disease due to their advantages of portability and wearability as well as their great potential for replacing clinical hospital‐centered blood purification with continuous in‐home hemodialysis. This Review summarizes the recent progress in microfluidic devices for hemodialysis. First, the history of kidney‐inspired hemodialysis is introduced. Then, recent achievements in the preparation of microfluidic devices and hemodialysis nanoporous membrane materials are presented and categorized. Subsequently, attention is drawn to the recent progress of nanoporous membrane‐based microfluidic devices for hemodialysis. Finally, the challenges and opportunities of hemodialysis microfluidic devices in the future are also discussed. This Review is expected to provide a comprehensive guide for the design of hemodialysis microfluidic devices that are closely related to clinical applications.

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“…Moreover, the hydrophilicity of nylon 66 is higher than that of many others polymers because of the presence of amide groups in the polymer backbone; nylon 66 is synthesized through precipitation by various aqueous solvent solutions [ 3 , 4 , 5 , 6 ]. Nylon 66 membranes are extensively employed in various separation processes involving electrospun nanofibers that are applied in water and air filtration, blood purification, biosensors, tissue engineering and drug delivery, enzyme immobilization and acoustical damping [ 7 , 8 , 9 , 10 , 11 ]. Among various techniques used to prepare nylon 66 membranes, immersion precipitation is the most widely used.…”

Section: Introductionmentioning

confidence: 99%

The Isothermal and Nonisothermal Crystallization Kinetics and Morphology of Solvent-Precipitated Nylon 66

Tseng

Tsai

2022

Polymers

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Solvent-precipitated nylon 66 (SP PA66) is a key material used to fabricate microfiltration membranes. The crystallization kinetics and behavior of SP PA66 were investigated through differential scanning calorimetry (DSC), polarized optical microscopy (POM) and X-ray diffraction (XRD). The Avrami equation was used to describe the isothermal crystallization of SP PA66. Nonisothermal crystallization behaviors were analyzed using Avrami equations modified by Jeziorny, Ozawa and Mo. The Avrami analysis demonstrated that the k values of SP PA66 were higher than those of neat PA66. The was between 2 and 3 indicating the presence of two- and three-dimensional mode with thermal nucleation. With an increasing cooling rate, the Jeziorny crystallization rate constant increased for SP PA66; however, the Ozawa model was not satisfactory for all SP PA66 samples. The Mo method suggested that SP PA66 had a faster crystallization rate than neat PA66 during the nonisothermal crystallization process. The solvents dissolved nylon 66, rearranged it and formed a regular hydrogen-bonded region. These regions served as nucleation sites and increased the crystallization rate constant in the subsequent melting process. The crystal morphology of the SP PA66 under the POM investigation exhibited Maltese cross spherulites. The sizes of the spherulites of SP PA66 were significantly smaller than those of neat PA66. Wide-angle XRD revealed that SP PA66 had the same crystal structure and a higher crystal perfection than neat PA66.

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Preparation and Characterization of Modified Nylon 66 Membrane for Blood Purification

Cited by 6 publications

References 21 publications

Graphene Oxide Nanocomposite Incorporated Poly(ether imide) Mixed Matrix Membranes for in Vitro Evaluation of Its Efficacy in Blood Purification Applications

Graphene Oxide Nanocomposite Incorporated Poly(ether imide) Mixed Matrix Membranes for in Vitro Evaluation of Its Efficacy in Blood Purification Applications

Recent Progress of Microfluidic Devices for Hemodialysis

The Isothermal and Nonisothermal Crystallization Kinetics and Morphology of Solvent-Precipitated Nylon 66

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