Preparation and characterization of nanosized Ag/SLN composite and its viability for improved occlusion

Swarnavalli, G. Cynthia Jemima; Dinakaran, S.; Divya, S.

doi:10.1007/s13204-016-0522-2

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…The pH of the dispersion was adjusted to 1.2 by addition of 0.1 M hydrochloric acid solution to the precipitated SLNs, and the precipitate was then collected by centrifuging at 12,000 rpm. The precipitate was re-dispersed in distilled water under sonication (13 mm probe, 65% amplitude and 1 min cycles) for 7 minutes 10 .…”

Section: Formulation Of Slnsmentioning

confidence: 99%

Formulation and evaluation of solid lipid nanoparticles of naringin to enhance its bioavailability

Vishal Tiwari, Sandeep Jain

2023

tjjpt

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The objective of the present work was to formulate solid lipid nanoparticles loaded with naringin for improving the bioavailability of naringin. The SLNs loaded with naringin were prepared by using different ratio of palmitic and stearic acid as the lipids and Tween 80 as the surfactant. The method nanoprecipitation was used for preparation of the SLNs. The surfactant (Tween 80) helps in steric stabilization of the SLNs. The size range of SLNs obtained on sonicating for 7 was found to be 429 ± 76 nm when stearic acid was used and 365 ± 28 nm when palmitic acid was used for the preparation of SLNs. The zeta potential of all the SLNs ranged from -16 to -27 mV suggesting a stable formulation. The percentage of drug incorporated during nanoparticle preparation was determined by centrifuging the drug loaded nanoparticles at 15,000 rpm for 15 min and separating the supernatant. The highest encapsulation of naringin (71.7 ± 8.6 %) was obtained when the concentration of palmitic acid was 0.14 mmol. The in vitro release of naringin from the SLNs was measured by dialysis method using simulated gastric fluid as the dissolution medium. In vitro release kinetics studies for naringin loaded SLNs exhibited a sustained release pattern. Sustained release was observed over a period of 3 days. The stability of NSLN-7 was studied by storing at 4 ± 1 °C for 30 days. The particle size remained stable at the end of the study with drug entrapment of 71.5 %. This suggests that the SLNs prepared are stable on storage.

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Section: Formulation Of Slnsmentioning

confidence: 99%

Formulation and evaluation of solid lipid nanoparticles of naringin to enhance its bioavailability

Vishal Tiwari, Sandeep Jain

2023

tjjpt

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“…The fine particle size of SLN is responsible for bio-adhesion to the stratum corneum thereby improving drug delivery to the skin. 4 In the current study, drug-loaded SLNs are incorporated into the transdermal gel to improve its efficacy. Those side effects could be minimized through site-specific drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Transdermal Gel Embedded with Solid Lipid Nanoparticles of Indomethacin

Hajwani¹,

Khan²,

Ansari³

et al. 2023

IJDDT

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Rheumatoid/osteoarthritis is one of the most common causes for lacking behind in the health sector. Medication in the form of tablets are already available in the market but has disadvantages. When these medicines are taken orally it cause heartburn and discomfort. The introduction of transdermal drug delivery is expected to solve this problem of side eff ects associated with oral delivery of drug. In the present study, indomethacin was loaded in solid lipid nanoparticles (SLN) which are then embedded in Carbopol gel for transdermal application. The solvent evaporation ultrasonication method was used for making SLNs. The formulation was evaluated for various parameters such as ; particle size and zeta potential of SLN using zetasizer as an instrument and gel formulations were evaluated for pH, spreading coeffi cient, viscosity, visual appearance and clarity. Gel-embedded SLN formulation was found to be a potential transdermal drug delivery system for NSAIDs like indomethacin to treat ailments like rheumatoid arthritis or osteoarthritis.

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Introduction to nanotechnology in personal care products

Biswas

Das

2022

Nanocosmeceuticals

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Preparation and characterization of nanosized Ag/SLN composite and its viability for improved occlusion

Cited by 6 publications

References 24 publications

Formulation and evaluation of solid lipid nanoparticles of naringin to enhance its bioavailability

Formulation and evaluation of solid lipid nanoparticles of naringin to enhance its bioavailability

Fabrication of Transdermal Gel Embedded with Solid Lipid Nanoparticles of Indomethacin

Introduction to nanotechnology in personal care products

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