2016
DOI: 10.15171/apb.2016.013
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Preparation and Characterization of Nanosuspension of Aprepitant by H96 Process

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Cited by 43 publications
(33 citation statements)
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“…Thus SEM pictures confirmed that the larger scaly particles of EE were successfully converted to nearly elongated, smaller sized nanoparticles with a smoother surface on size reduction. The particle size of EENS increased after lyophilization but were still smaller than that of EE [33] .…”
Section: Resultsmentioning
confidence: 91%
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“…Thus SEM pictures confirmed that the larger scaly particles of EE were successfully converted to nearly elongated, smaller sized nanoparticles with a smoother surface on size reduction. The particle size of EENS increased after lyophilization but were still smaller than that of EE [33] .…”
Section: Resultsmentioning
confidence: 91%
“…SEM studies were performed using an SEM (Jeol JSM-6360, Japan) at 20 kV accelerating voltage and high vacuum. Before analysis, lyophilized EENS were first placed on two-sided carbon tape and then, sputtered with gold-palladium alloy up to 3-5 nm of thickness [30,33] .…”
Section: Scanning Electron Microscopy (Sem)mentioning
confidence: 99%
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“…10 mL portion of the freshly prepared and cooled nanosuspension was centrifuged at 1000 rpm for 10 minute using a Remi centrifuge. The supernatant was removed and the amount of unincorporated drug was measured by taking the absorbance of the supernatant solution at 289 nm by using UV spectrophotometer [18].…”
Section: Entrapment Efficiencymentioning
confidence: 99%