Preparation and Characterization of Oleanolic Acid Nanoparticles

Tang, Shengnan; Hao, Jikui; Gao, Dawei; Duan, Jinting; Liu, Zhiwei

doi:10.2174/1573412911309020008

Cited by 4 publications

(2 citation statements)

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“…The NP by precipitation and liposome methods achieved high encapsulation efficiencies of 86.7% and 92.6%, respectively. Both nanoparticle types exhibited increased stability at 4 °C across various conditions [ 152 ]. Zhang et al developed a novel vitamin E-modified aliphatic polycarbonate-based polymeric nanoparticle (mPEG-PCC-VE NP) delivery system to improve oral absorption of OA.…”

Section: Challenges In Oa Deliverymentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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The growing interest in oleanolic acid (OA) as a triterpenoid with remarkable health benefits prompts an emphasis on its efficient use in pharmaceutical research. OA exhibits a range of pharmacological effects, including antidiabetic, anti-inflammatory, immune-enhancing, gastroprotective, hepatoprotective, antitumor, and antiviral properties. While OA demonstrates diverse pharmacological effects, optimizing its therapeutic potential requires overcoming significant challenges. In the field of pharmaceutical research, the exploration of efficient drug delivery systems is essential to maximizing the therapeutic potential of bioactive compounds. Efficiently delivering OA faces challenges, such as poor aqueous solubility and restricted bioavailability, and to unlock its full therapeutic efficacy, novel formulation strategies are imperative. This discussion thoroughly investigates different approaches and advancements in OA drug delivery systems with the aim of enhancing the biopharmaceutical features and overall efficacy in diverse therapeutic contexts.

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Section: Challenges In Oa Deliverymentioning

confidence: 99%

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Wasim,

Bergonzi

2024

Pharmaceutics

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“…Regardless of therapeutic aims, in most cases the methods used to prepare liposomes involve the use of organic solvents to obtain a lipid solution. From the original method of Banghan [30] to those based on simple or multiple emulsification [31][32][33], as well as modified ethanol injection methods [34], all require the use and later removal of an organic solvent. Little attention has been paid to solvent-free procedures, although high-pressure homogenization and supercritical fluid methods have been applied to prepare liposomes [35][36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization

et al. 2018

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Technological advances in lipid vesicles facilitate optimization of their properties to achieve therapeutic goals and promote alternative drug administration routes. Sildenafil citrate (SC) is orally administered for the treatment of pulmonary hypertension, but local release would be advantageous in terms of efficacy and safety. In the present study, liposomes from egg phosphatidylcholine and cholesterol loaded with SC, with and without d-α-tocopheryl polyethylene glycol 1000 succinate (Vit E TPGS), were prepared by sonication of the components. A transmembrane pH gradient was applied for active loading of liposomes, and the size, zeta potential, and entrapment efficiency (EE%) were determined. The liposomes were lyophilized and then nebulized. The nebulized samples were collected and the EE% was determined. The transmembrane pH gradient produced a significant increase in the EE% (from 17.68 ± 4.25% to 89.77 ± 7.64%) and, after lyophilization, the EE% remained the same as that of the originals, but the size and zeta potential were modified. EE% of liposomes decreased upon nebulization, particularly for those with Vit E TPGS. Thus, the additives used for lyoprotection reduced the impact of nebulization. Additional studies are essential, but according to these results, SC-loaded liposomes can be considered as suitable and safe carriers for the local release of sildenafil in the pulmonary system.

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Whole whey stabilized oleanolic acid nanosuspension: Formulation and evaluation study

Banarase¹,

Kaur²

2022

Journal of Drug Delivery Science and Technology

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Preparation and Characterization of Oleanolic Acid Nanoparticles

Cited by 4 publications

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Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Unlocking the Potential of Oleanolic Acid: Integrating Pharmacological Insights and Advancements in Delivery Systems

Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization

Whole whey stabilized oleanolic acid nanosuspension: Formulation and evaluation study

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