Preparation and Characterization of Particles Produced From Sericin and Alginate Blend With Incorporated Drug

Abstract

-The use of biodegradable polymers for controlled release drug delivery systems are being widely studied, because the therapeutic benefits that can be achieved. Studies have shown that exposure of diclofenac sodium (DS) in acid medium, such as occurring after oral ingestion of the drug, decreases the antiinflammatory activity. Thus, the incorporation of the drug into biopolymer particles becomes an alternative and the therapeutic effect is maintained due to the protection offered by the biomaterials. The objective of this study is to evaluate the incorporation of diclofenac sodium in particles formed from the blend of sericin and alginate subjected to gelation process with CaCl 2 . Incorporation efficiency measurement, interaction and morphology of the drug with mixtures of biopolymers were made. Also, the particle characterization was carried out to analyze the physical-chemical parameters, such as the determination of the property pH ZPC.