Preparation and characterization of polymer/layered silicate pharmaceutical nanobiomaterials using high clay load exfoliation processes

Villaça, Jaqueline Correia; Silva, Luiz Cláudio R. Pereira da; Barbosa, Luisa Helena Falcão; Rodrigues, Carlos Rangel; Lira, Luiz Marcelo; Carmo, Flávia Almada do; Sousa, Valéria Pereira de; Tavares, Maria Inês Bruno; Cabral, e Lucio Mendes

doi:10.1016/j.jiec.2013.12.110

Cited by 13 publications

(6 citation statements)

References 61 publications

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“…The analyses were made at the Pharmaceutical Technology Laboratory of the Federal University of Rio de Janeiro. 26,27 Statistical analysis Statistically significant differences among experimental groups for the enthalpy fusion values (DSC analysis) were detected based on differences between the individual means determined using a non-parametric ANOVA followed by Tukey's post hoc test. The statistical analysis was performed using the software GraphPad Prism 5 (GraphPad Software Inc., La Jolla, USA) and the significance level (p-value) was set to 0.05.…”

Section: Thermal Analysis By Differential Scanning Calorimetry (Dsc) mentioning

confidence: 99%

Structural and thermal analyses of zinc and lactose in homeopathic triturated systems

et al. 2017

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Our results suggested no structural changes due to the trituration and dynamization process. However, TG and DSC analyses permit the differentiation of dynamized and non-dynamized groups, suggesting the dynamization process induced a significant increase in the degradation heat. These results call for further calorimetric studies with other homeopathic dilutions and other methodologies, to better understand the dynamics of these systems.

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Section: Thermal Analysis By Differential Scanning Calorimetry (Dsc) mentioning

confidence: 99%

Structural and thermal analyses of zinc and lactose in homeopathic triturated systems

et al. 2017

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“…The domain displacement and appearance of a novel domain, as well as the low T 1 H value, can be evidence of structural disorder, mostly related to delamination/exfoliation of the particles. In addition, the high mobility of MT-8 contributed to the decreased domain intensity, which indicates a modification in the structural organization of the Na-Mt after high-energy milling process (figure 7) [43]. In untreated Na-Mt, the presence of trace impurities of paramagnetic minerals, especially quartz and feldspars, can contribute to the results [44].…”

Section: Nuclear Magnetic Resonancementioning

confidence: 98%

Full-factorial design for statistical planning of attritor milling parameters and evaluation of effects on particle size and structure of sodium-montmorillonite

et al. 2020

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High-energy milling is the most widely used method in industry to achieve nanosized particles due to its low cost and potential to rapidly provide large-scale production. Using a top-down approach based on wet attritor milling, we investigated different combinations of the factors predicted from the 2 3 full-factorial design were investigated to process sodium-montmorillonite (Na-Mt). Statistical analyses were performed to determine the most suitable process conditions and to evaluate the factors influencing the response variable. Materials obtained from the different procedures were analyzed by energy dispersive x-ray spectroscopy, powder x-ray diffraction, nuclear magnetic resonance, Fourier transform infrared spectroscopy and dynamic light scattering. Particle surface, size and morphology were examined by scanning electron microscopy while the lamellar structure was observed by transmission electron microscopy. The results predicted using factorial design indicated that the milling time has a significant positive influence on the particle size of Na-Mt. The effect of rotation speed was nearly comparable and its impacts was similar to that of milling time. The interaction effects were significant at 99% confidence level (p<0.01). The optimal process conditions were: 3% Na-Mt concentration (w/v), 3 h of milling time and a rotation speed of 1867 rpm, resulting in a particle size of 282.23 nm. The proposed factorial model proved to be reliable and adequate (R 2 =0.9853, PredR 2 =0.9753 and AdjR 2 =0.9804). The wet attritor milling can be considered as an economical and effective alternative for the mechanical treatment of a wide variety of powders, aiming to achieve nanosized structures.

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“…The resulting matrix was suitable for the controlled release of active ingredients with stabilizing collagens of human and bacterial collagenases in a concentration-dependent manner [236,237] prepared layered silicate-chitosan nanocomposites with high clay loadings, which could be used in the food, medical, and pharmaceutical industries [239,240]. Cross-linked polymers prepared from chitosan-PVA could be useful for food applications such as food packaging as well [241].…”

Section: Page 11 Of 35mentioning

confidence: 99%

“…Hydrophilic polymers including polyvinylpyrrolidone, chitosan, methylcellulose, and other amino polymers exhibited a high affinity for nanoclays with sodium and organophilic clays [239,242]. Muzzarelli et al showed that chitosan and its derivatives exhibited great versatility in their flocculation and adsorption capacities, primarily due to their cationic nature and macromolecular structures.…”

Section: Page 11 Of 35mentioning

confidence: 99%

Recently developed applications for natural hydrophilic polymers

Halake

Kim

Birajdar

et al. 2016

Journal of Industrial and Engineering Chemistry

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Preparation and characterization of polymer/layered silicate pharmaceutical nanobiomaterials using high clay load exfoliation processes

Cited by 13 publications

References 61 publications

Structural and thermal analyses of zinc and lactose in homeopathic triturated systems

Structural and thermal analyses of zinc and lactose in homeopathic triturated systems

Full-factorial design for statistical planning of attritor milling parameters and evaluation of effects on particle size and structure of sodium-montmorillonite

Recently developed applications for natural hydrophilic polymers

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