Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology

Sheng, Si; Yin, Xiaoying; Chen, Fangmei; Lv, Yixin; Zhang, Lin; Cao, Menghui; Sun, Yun

doi:10.1208/s12249-020-01715-y

Cited by 10 publications

(9 citation statements)

References 32 publications

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“…PLA, polyethylene glycol, and PVA were well explored biodegradable polymers for drug-delivery systems. − Polyethylenimine (PEI) with both linear and branched forms exhibits excellent transfection properties with high cationic activity and low cytotoxicity effects. The advantage of using PEI is it consists of repeating amphiphilic structures with an amine group and ethylene backbone.…”

Section: Introductionmentioning

confidence: 99%

Enhanced In Vitro Wound Healing Using PVA/B-PEI Nanofiber Mats: A Promising Wound Therapeutic Agent against ESKAPE and Opportunistic Pathogens

Mary

Raghavan

Kagula

et al. 2021

ACS Appl. Bio Mater.

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Opportunistic skin pathogens and their resistance to pre-existing therapeutics are a challenge to normal physiological wound healing processes. Consistent development of antimicrobial agents is required to overcome the complications raised by antimicrobial resistance. An effective alternative proposed in recent research includes the use of antimicrobial nanoparticles or nanobiopolymers. Unfortunately, metallic nanoparticles that have been proven as antimicrobial agents also possess a certain level of toxicity. In this work, we demonstrate the use of a cationic polymer, branched polyethyleneimine (B-PEI), that has been electrospun to obtain a scaffold/fiber (B-PEI NF) mat resulting in a large surface area-to-volume ratio. SEM analysis revealed that the average diameter of the obtained fibers is 240 nm. The formation of nanoscaffold modulates the controlled release of the polymer from the matrix resulting in long-term effects. The antimicrobial and antibiofilm activity of the B-PEI nanofiber (B-PEI NF) was evaluated against ESKAPE pathogens (Pseudomonas aeruginosa and Staphylococcus aureus) and also against Candida albicans. Dose-dependent inhibition was observed for microbial growth and biofilm for all three test organisms, the minimum inhibitory concentration required for inhibiting P. aeruginosa, S. aureus, and C. albicans is 33.125, 26.5, and 19.875 μM, respectively, in 2 mL of bacterial/fungal broth. Crystal violet and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays showed significant reduction in biomass and cell viability of sessile cells, respectively, within the biofilm after treatment using B-PEI NFs. A B-PEI NF matrix promotes cell migration and wound healing processes by mimicking the extracellular matrix. In vitro wound healing studies showed a fivefold increase in cell migration and wound healing by B-PEI NFs (97% wound coverage in 17 h) when compared to B-PEI (15% wound coverage in 17 h). The in vitro wound healing assays confirmed the biocompatibility and better wound healing activity of B-PEI NF mats.

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Section: Introductionmentioning

confidence: 99%

Enhanced In Vitro Wound Healing Using PVA/B-PEI Nanofiber Mats: A Promising Wound Therapeutic Agent against ESKAPE and Opportunistic Pathogens

Mary

Raghavan

Kagula

et al. 2021

ACS Appl. Bio Mater.

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“…Electrospinning nanofiber membranes have the characteristics of a large specific surface area, high porosity, and easy modification [37][38][39]. They have been widely used in tissue engineering, drug delivery, catalysis, wound dressings, and other fields [40][41][42][43][44][45]. Sueyoshi et al [46] used optically active glutamic acid (Zd-Glu and Zl-Glu) as a template molecule and cellulose acetate as the base membrane to prepare molecularly imprinted membranes by means of electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Recognition Properties of Molecularly Imprinted Nanofiber Membrane of Chrysin

Wang

Cheng

et al. 2022

Polymers

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The separation and extraction of chrysin from active ingredients of natural products are of great significance, but the existing separation and extraction methods have certain drawbacks. Here, chrysin molecularly imprinted nanofiber membranes (MINMs) were prepared by means of electrospinning using chrysin as a template and polyvinyl alcohol and natural renewable resource rosin ester as membrane materials, which were used for the separation of active components in the natural product. The MINM was examined using Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The adsorption performance, adsorption kinetics, adsorption selectivity, and reusability of the MINM were investigated in static adsorption experiments. The analysis results show that the MINM was successfully prepared with good morphology and thermal stability. The MINM has a good adsorption capacity for chrysin, showing fast adsorption kinetics, and the maximum adsorption capacity was 127.5 mg·g−1, conforming to the Langmuir isotherm model and pseudo-second-order kinetic model. In addition, the MINM exhibited good selectivity and excellent reusability. Therefore, the MINM proposed in this paper is a promising material for the adsorption and separation of chrysin.

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“…1−5 These EVOHs also combine interesting features such as transparency, processability, antistatic properties, film-forming capacity, and high resistance to hydrocarbons, oils, and organic solvents. 2,5 Moreover, their biocompatibility and nontoxicity make EVOHs valuable materials in the biomedical area 6−9 notably in drug release, 10,11 protein separation, 12−14 and water purification. 15 While EVOHs are suitable for many uses, their chemical modification may be necessary to fine-tune their properties and functionalities in order to meet the more and more stringent requirements of today's cutting-edge applications.…”

Section: ■ Introductionmentioning

confidence: 99%

CO₂-Derived Methylene Oxazolidinone: A Platform Building Block for Functionalizing Ethylene–Vinyl Alcohol Copolymers

et al. 2021

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Ethylene–vinyl alcohol copolymers (EVOHs) are important materials available in a variety of compositions and valued in countless applications. In spite of their great adaptability offered by the adjustment of their ethylene content, the chemical modification of EVOHs is often considered to tune their properties and functionalities in order to meet the stringent requirements of today’s applications. While post-polymerization modification of the pendant hydroxyl groups of EVOHs is the prevailing functionalizing strategy, this multistep approach consumes part of the alcohols of EVOHs and remains limited in terms of functions. This work reports a straightforward platform for the synthesis of functional EVOHs, in particular, amino derivatives, involving a CO2-derived oxazolidinone-containing methylene heterocycle, namely, 4,4-dimethyl-5-methyleneoxazolidin-2-one (DMOx). The ethylene/DMOx and ethylene/vinyl acetate/DMOx copolymerizations were implemented by conventional and reversible deactivation radical copolymerization. The resulting oxazolidinone-containing ethylene-based copolymers were then converted into novel vicinal amino alcohol-functional EVOHs via hydrolysis of esters and oxazolidinones. A selective post-modification method of these 1,2-amino alcohol-functional EVOHs into their oxazolidine counterparts is also reported. Finally, the peculiar thermal and solution properties, including pH-responsiveness, of these novel vicinal amino alcohol- and oxazolidine-functional EVOHs as well as oxazolidinone EVAs are discussed.

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Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology

Cited by 10 publications

References 32 publications

Enhanced In Vitro Wound Healing Using PVA/B-PEI Nanofiber Mats: A Promising Wound Therapeutic Agent against ESKAPE and Opportunistic Pathogens

Enhanced In Vitro Wound Healing Using PVA/B-PEI Nanofiber Mats: A Promising Wound Therapeutic Agent against ESKAPE and Opportunistic Pathogens

Preparation and Recognition Properties of Molecularly Imprinted Nanofiber Membrane of Chrysin

CO₂-Derived Methylene Oxazolidinone: A Platform Building Block for Functionalizing Ethylene–Vinyl Alcohol Copolymers

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Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology

Cited by 10 publications

References 32 publications

Enhanced In Vitro Wound Healing Using PVA/B-PEI Nanofiber Mats: A Promising Wound Therapeutic Agent against ESKAPE and Opportunistic Pathogens

Enhanced In Vitro Wound Healing Using PVA/B-PEI Nanofiber Mats: A Promising Wound Therapeutic Agent against ESKAPE and Opportunistic Pathogens

Preparation and Recognition Properties of Molecularly Imprinted Nanofiber Membrane of Chrysin

CO2-Derived Methylene Oxazolidinone: A Platform Building Block for Functionalizing Ethylene–Vinyl Alcohol Copolymers

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Product

Resources

About

CO₂-Derived Methylene Oxazolidinone: A Platform Building Block for Functionalizing Ethylene–Vinyl Alcohol Copolymers