Preparation and characterization of radioactive Co/¹⁸⁸Re stents intended for lung cancer treatment using an electrodeposition method

Abstract

A procedure for electroplating a Co/(188)Re alloy layer on metal coils (stents) at room temperature was developed. The electroplating of the Co/(188)Re alloy layer was carried out at a current density of 93 A m(-2) and produced a physically strong Co/(188)Re alloy layer that adhered well to a thin gold strike layer on top of the stent material. The final gold layer was also stable. An empirically-found equation correlates the radioactive electroplating efficiency factor to the concentration of the radioisotope and was used to deposit predetermined amounts of radioactivity on the stent surface. Radioactive stents can be prepared and quality control performed within 2 hours using an automated electroplater and dosimetric quality control system. The radioactivity was homogeneously distributed on the stent surface. The in vitro stability in human plasma at 37 degrees C was found to be greater than 95% for both Wallstent and Ultraflex stent after 72 hours of incubation. A clinical pilot trial is planned after successful completion of animal testing.

Radiochemistry and radiopharmaceuticals

“…A new europium-155/samarium-154 source has been developed 285 for Mo¨ssbauer spectroscopy. Two methods have been proposed 286,287 for the electrodeposition of rhenium-188 producing potential sources, but actually made for radiation therapy.…”

On the application of electrochemical techniques for the preparation of 57Co source core, encapsulation and quality evaluation for radiometric assay of nuclear fuel rods

“…Such sources are generally prepared by molecular beam epitaxy or sputtering technique, using ultrahigh vacuum system [18][19][20][21][22]. An alternative technique is electrodeposition and the potential utility of this technique for the preparation of radioactive source has been well demonstrated [8][9][10][23][24][25]. Very low concentrations of metal ions can be deposited on the surface of a substrate with good reproducibility and high throughput by this method.…”

“…Several strategies have been explored for the preparation of radioactive sources [2][3][4][5][6][7][8][9][10] for various applications. Preparation of Mössbauer sources in which 57 Co is diffused at high temperatures in inert atmosphere throughout the metallic substrate to obtain more or less a uniform distribution of cobalt in metallic form has been reported [11][12][13][14][15][16][17].…”

Development of a micro electrochemical cell forin-situdeposition of63Ni for use in electron capture detector (ECD) in gas chromatography

“…In recent years, electrodeposition of radioactive material on a metallic substrate has attracted interest owing to its technical simplicity, reproducibility of results, quick, inexpensiveness preparation, and the ability to accommodate large substrate areas and complex substrate geometries [6][7][8][9][10][11][12][13]. In order to tap the potential of electrochemical technique for the preparation of 63 Ni source, we have reported the preparation of 63 Ni source for the calibration of thermoluminescence dosimeter (TLD) [14] in which we have optimized various experimental conditions to electrodeposit 63 Ni over the copper substrate with high adhesion.…”