Preparation and Characterization of Rutin–Loaded Zein–Carboxymethyl Starch Nanoparticles

Abstract

In this work, rutin (RT)–loaded zein–carboxymethyl starch (CMS) nanoparticles were successfully prepared by the antisolvent precipitation method. The effect of CMS on composite nanoparticles at different concentrations was studied. When the ratio of zein–RT–CMS was 10:1:30, the encapsulation efficiency (EE) was the highest, reaching 73.5%. At this ratio, the size of the composite nanoparticles was 196.47 nm, and the PDI was 0.13, showing excellent dispersibility. The results of fluorescence spectroscopy, FTIR, XRD, and CD showed that electrostatic interaction, hydrogen bonding, and hydrophobic interaction were the main driving forces for the formation of nanoparticles. It can be seen from the FE–SEM images that the zein–RT–CMS nanoparticles were spherical. With the increase in the CMS concentration, the particles gradually embedded in the cross–linked network of CMS (10:1:50). After RT was loaded on zein–CMS nanoparticles, the thermal stability and pH stability of RT were improved. The results showed that zein–CMS was an excellent encapsulation material for bioactive substances.

Synthesis and Evaluation of Rutin–Hydroxypropyl β-Cyclodextrin Inclusion Complexes Embedded in Xanthan Gum-Based (HPMC-g-AMPS) Hydrogels for Oral Controlled Drug Delivery

“…Rutin (RT), a flavonoid, also called vitamin P, can be found in a wide variety of foods, including apples (350 to 4780 μg/g), citrus fruits (2.7 to 8106.7 µg/g), and tea (303 to 479 μg/g) [ 3 ]. Rutin is an important metabolite of Ruta graveolens [ 4 ].…”

Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and inhibiting ferroptosis

“…The FT-IR results showed that compared to PDA, a new peak at 2,890 cm −1 was observed in PP group, indicating that PEG is bound to PDA. 19 Furthermore, a new peak at approximately 3,400 cm −1 , belonging to the hydroxyl stretching vibration of rutin, 20 was observed in the PRP group ( Figure 1 D), indicating that rutin was successfully loaded onto the PP NPs. Similarly, the UV-Vis spectra showed a characteristic absorption peak at 359 nm for PPR NPs, indicating the successful binding of rutin to PP NPs ( Figure 1 E).…”

Aplicação de dsRNA sintético ou associado a nanocarreadores de zeína para controle de Tuta absoluta (Meyrick, 1917) por RNAi

“…Nanocarreadores também podem estimular a penetração e distribuição do dsRNA na planta (WU; LI, 2022;YONG et al, 2022), o que poderia ser útil para controle de insetos-praga sugadores de seiva, minadoras de folhas, caules ou consumidores de raízes .…”

“…A dimensionalidade de um nanocarreador é uma importante característica no que se diz respeito ao desenvolvimento de sistemas de entrega de biopesticidas à base de dsRNA (Figura 5) . A dimensão do nanocarreador pode influenciar a eficiência da entrega do dsRNA ao inseto e a penetração e translocação nas plantas (HU;LI, 2022;. Nanomateriais de zero dimensão (0-D) apresentam todas as suas três dimensões na escala nanométrica, o que os tornaria mais eficientes na passagem pela membrana peritrófica do intestino dos insetos e na penetração e transporte nas plantas LINKE et al, 2022;SINGH et al, 2022).…”

“…Devido à sua insolubilidade em água, a zeína tem a habilidade de formar espontaneamente estruturas em escala nanométrica a partir de sua diluição em solvente orgânico, seguida da exposição em meio aquoso, método conhecido como precipitação por antissolvente (PADUA; GARDIOLA, 2015). Este é um dos métodos mais barato e simples para síntese de nanocarreadores de zeína (nZ) e que também garante uniformidade e mais baixo tamanho médio dos coloides (DE OLIVEIRA et al, 2019;LI et al, 2022;PASCOLI et al, 2020).…”