Preparation and Characterization of Self-Assembled Poly(l-Lactide) on the Surface of β-Tricalcium Diphosphate(V) for Bone Tissue Theranostics

Abstract

This work was aimed to obtain and characterize the well-defined biocomposites based on β-tricalcium diphosphate(V) (β-TCP) co-doped with Ce3+ and Pr3+ ions modified by poly(l-lactide) (PLLA) with precise tailored chain length and different phosphate to polymer ratio. The composites as well as β-tricalcium diphosphate(V) were spectroscopically characterized using emission spectroscopy and luminescence kinetics. Morphological and structural properties were studied using X-Ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). The self-assembled poly(l-lactide) in a shape of rose flower has been successfully polymerized on the surface of the β-tricalcium diphosphate(V) nanocrystals. The studied materials were evaluated in vitro including cytotoxicity (MTT assay) and hemolysis tests. The obtained results suggested that the studied materials may find potential application in tissue engineering.

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

“…Among the synthetic biodegradable polymers explored for tissue regeneration, polylacticacid-based nanomaterials find their place in various biological applications, i.e., regulated drug release, gene therapy, implant coatings, etc. [78][79][80]. Wiglusz et al (2020) analytically characterized beta-calcium diphosphate-modified poly(L-lactide) nanocomposites with a tunable chain length and varied phosphate-to-polymer ratios via self-assembly.…”

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