Preparation and characterization of simvastatin nanoparticles using rapid expansion of supercritical solution (RESS) with trifluoromethane

Fattahi, Alborz; Karimi-Sabet, Javad; Keshavarz, Ali; Golzary, Abooali; Rafiee-Tehrani, Morteza; Dorkoosh, Farid Abedin

doi:10.1016/j.supflu.2015.05.013

Cited by 49 publications

(15 citation statements)

References 44 publications

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“…Nanoparticles have comparatively greater intracellular uptake than microparticles. They can penetrate throughout the submucosal layers while the microparticles which are larger in size can't penetrate and remain localized in the epithelial lining [59]. Generally, SIM is nearly insoluble in water and is not well absorbed.…”

Section: Gels and Hydrogelmentioning

confidence: 99%

Prospective Role of Simvastatin on Wound Healing: Review of the Literature

Sameh¹,

Aly²,

Abou-Taleb³

et al. 2018

J Bioequiv Availab

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Background: Wound healing is a normal biological complex and dynamic process of substituting injured and misplaced cellular structures and tissue layers. This complicated development is achieved through four different phases: haemostasis, inflammation, proliferation, and finally remodelling. These four phases must occur in the proper sequence and time frame to achieve successful wound healing. Over years topical antibiotics were applied on wounds but it causes side effects and resistance; that's why it was a necessity to find a new topical wound healing drugs rather than antibiotics. Methods: Literature was searched in NCBI (The National Center for Biotechnology Information Advances Science and Health), Wiley online library, ScienceDirect database using the keywords Simvastatin, wound healing, Topical formulation. Articles that seemed suitable based on title and abstract were included. Also, a personal collection of literature on the subject pleiotropic effects of simvastatin, hydrogels, and polymeric nanoparticles was referred. Results: Beside cholesterol-lowering effect of Simvastatin (SIM), it has many unusual therapeutic modalities for different pathological disorders such as healing bone tissue, cancer cell inhibition, many inflammatory diseases and wound healing. SIM wound healing induction arises from its angiogenesis activity and antibacterial activity. It can interfere with bacterial protein synthesis and inhibits both multiple biosynthetic pathways and cellular processes in bacteria without the conventional antibiotics side effects or fear of bacterial resistance. Conclusion: This review discusses the wound types and wound healing process, the nanosizing advantage in wound healing, gels and hydrogel characters and the approved application of simvastatin topically to wound healing via promotion of epithelialization and antibacterial activity.

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Section: Gels and Hydrogelmentioning

confidence: 99%

Prospective Role of Simvastatin on Wound Healing: Review of the Literature

Sameh¹,

Aly²,

Abou-Taleb³

et al. 2018

J Bioequiv Availab

View full text Add to dashboard Cite

show abstract

“…In order to produce the mentioned items, it is necessary to utilize various methods and perform different processes such as the rapid expansion of supercritical solution (RESS), the gas anti-solvent (GAS), the supercritical anti-solvent (SAS), and the particles from gas-saturated solution (PGSS) (Knez and Weidner, 2003;Shariati and Peters, 2003;Yeo and Kiran, 2005;Cansell and Aymonier, 2009). For example, this technology is applied in the pharmaceutical industry to produce nanoparticles (Fages et al, 2004;Pathak et al, 2006;Reverchon et al, 2009;Keshavarz et al, 2012;Akbari et al, 2015;Masoodiyeh et al, 2015;Fattahi et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Rad

Karimi-Sabet

Varaminian

2019

Braz. J. Chem. Eng.

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Due to the importance of supercritical fluid technology (SFT) in different industries, it has been the subject of intense research in recent decades. Solubility is a key concept in SFT. In fact, obtaining knowledge about the theoretical concepts of solubility and related experimental measurement methods can be useful in developing and improving the quality of research in this field. This study reviews the fundamental knowledge of solubility in supercritical fluids and investigates the significant topics in this field, including high-pressure phase behavior, experimental measurement methods, modeling, and molecular simulation of solubility.

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“…Many methods or techniques such as micronization, solid dispersion, cyclodextrin complexation, microemulsion, liposomes, nanoparticles, phospholipid complex, and self-microemulsifying drug delivery system (SMEDDS), etc. have been tried to improve the solubility, dissolution rate and thus oral bioavailability of the drug (4)(5)(6)(7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats

Ning

Fan

et al. 2018

Acta Pharmaceutica

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Simvastatin is poorly bioavailable because it is practically insoluble in water and shows dissolution rate-limited absorption. Solubilizing effects of several β-cyclodextrin (βCD) derivatives such as HPβCD, SBEβCD and DMβCD on simvastatin in aqueous solution were investigated using the phase solubility technique. The solubility diagram of simvastatin with each βCD derivative could be classified as AL-type, indicating soluble complex formation of 1:1 stoichiometry. Among the above βCD derivatives DMβCD was found to be the ideal complexing agent for improving drug solubility. The simvastatin complex with DMβCD was prepared using the co-evaporation method and was then characterized by differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and in vitro dissolution. Dissolution and pharmacokinetic studies indicated that the simvastatin/DMβCD complex exhibited an increased dissolution rate, rapid absorption, and improved bioavailability in rats compared to free drug. Maximum plasma concentration (cmax) and the time to reach it (tmax) were 21.86 μg mL-1 and 1.4 h for the drug complex, 8.25 μg mL-1 and 3.0 h for free drug, respectively. Main pharmacokinetic parameters such as tmax, cmax were significantly different (p < 0.01) between the simvastatin complex and free drug. Bioavailability of the simvastatin complex relative to free drug was up to 167.0 %.

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Preparation and characterization of simvastatin nanoparticles using rapid expansion of supercritical solution (RESS) with trifluoromethane

Cited by 49 publications

References 44 publications

Prospective Role of Simvastatin on Wound Healing: Review of the Literature

Prospective Role of Simvastatin on Wound Healing: Review of the Literature

Study of Solubility in Supercritical Fluids: Thermodynamic Concepts and Measurement Methods - A Review

Preparation and characterization of simvastatin/DMβCD complex and its pharmacokinetics in rats

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