2015
DOI: 10.1002/masy.201400128
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Preparation and Characterization of Succinyl‐Chitosan Nanoparticles for Drug Delivery

Abstract: Summary: Succinyl-Chitosan (SCS), a water soluble CS derivative, exhibits biocompatibility, low toxicity and long-term retention in the body. SCS offers unique characteristics as polymer for obtaining drug delivery nanosystems, due to its many reactive amino, hydroxyl, and carboxylic acid pendant groups. Chemical modifications of SCS with antibodies and other active species are easily achieved through bonding with these groups, allowing targeting and detection. In this work, SCS was obtained by amidation of pr… Show more

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Cited by 17 publications
(7 citation statements)
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“…This indicates that NSCS became highly ionized with negative charges due to larger amount of deprotonated carboxyl groups (-COO − ). These findings are in agreement with published studies (Miranda et al 2006;Monsalve et al 2015).…”
Section: Measurement Of Zeta-potential (Zp) and Potentiometric Titrationsupporting
confidence: 94%
“…This indicates that NSCS became highly ionized with negative charges due to larger amount of deprotonated carboxyl groups (-COO − ). These findings are in agreement with published studies (Miranda et al 2006;Monsalve et al 2015).…”
Section: Measurement Of Zeta-potential (Zp) and Potentiometric Titrationsupporting
confidence: 94%
“… Finally, peaks b and c both exhibited cross peaks to an amide H attached to CS in the 1 H– 1 H NOESY spectrum (Supplemental Figure 3), indicating a likely covalent attachment to CS. These peaks further yielded a chemical signature similar to succinyl CS found in the literature. These NMR data suggested a covalent modification to CS (Figure B), as well as the presence of hydrolyzed products, which may stabilize the positive charge of CS.…”
Section: Resultssupporting
confidence: 74%
“…The grafting agent can be a hydrophobic moiety, such as cholesterol [ 27 ], cholic [ 28 ], and deoxycholic acid [ 29 ], or 5β-cholanic acid [ 30 ], to form micelles that can entrap lipophilic drugs or it can be the drug itself. Frequently, a water soluble CS derivative, such as glycol chitosan [ 31 ] or succinyl chitosan [ 32 ], is used instead of CS. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions [ 33 ].…”
Section: Introductionmentioning
confidence: 99%