Preparation and Characterization of Sugar Cane Wax Microspheres Containing Indomethacin

Formulation and Characterization of Gelucire Pellets for Sustained Release of Ibuprofen

“…Drug loading and entrapment efficiency was found to be slightly higher for pellets prepared with lower amount of GL and slower agitation speed (these results are summarized in Table 2). Drug loading increased probably with increase in pellets size due to larger surface area, resulting in an increase in entrapment efficiency 20 . This could be confirmed by particle size analysis (discussed later).…”

“…Pellets are receiving increased attention. They are defined as spherical, freeflowing granules with a narrow size distribution, typically varying between 500 and 1500 µm for pharmaceutical applications 20 . The interest in pellets as dosage forms (filled into hard gelatin capsules or compressed into disintegrating tablets) has been increasing continuously, since their multiparticulate nature offers some important pharmacological as well as technological advantages over conventional single-unit solid dosage forms.…”

“…The interest in pellets as dosage forms (filled into hard gelatin capsules or compressed into disintegrating tablets) has been increasing continuously, since their multiparticulate nature offers some important pharmacological as well as technological advantages over conventional single-unit solid dosage forms. Smaller sized pellets are rapidly emptied from the stomach regardless of the feeding state of the patient and influence the gastric emptying rate on the upper gastro-intestinal transit time 20 . Multi particulate unit dosage forms such as pellets, reduces the intra and inter-subject variability in gastric emptying times and exhibits easy distribution of the contents at gastrointestinal tract, compared to single-unit dosage forms 20 .…”

“…Smaller sized pellets are rapidly emptied from the stomach regardless of the feeding state of the patient and influence the gastric emptying rate on the upper gastro-intestinal transit time 20 . Multi particulate unit dosage forms such as pellets, reduces the intra and inter-subject variability in gastric emptying times and exhibits easy distribution of the contents at gastrointestinal tract, compared to single-unit dosage forms 20 . The uniform dispersion of a drug into pellets reduces the risk of high drug concentration, dose dumping and irritating effect on gastric mucosa.…”