Preparation and characterization of water-soluble chitin and chitosan derivatives

Sugimoto, M.; Morimoto, Minoru; Sashiwa, Hitoshi; Saimoto, Hiroyuki; Shigemasa, Yoshihiro

doi:10.1016/s0144-8617(97)00235-x

Cited by 320 publications

(165 citation statements)

References 20 publications

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“…It can be seen that grafting PEG onto CKGM decreases the viscosity of the solution at low shear rates. This is consistent with reports of PEGylation of polysaccharides such as PEG-chitosans (Jeong et al, 2008;Sugimoto et al, 1998). This result indicates that the introduction of hydrophilic PEG chains on the carboxyl groups destroyed the inherent structure Fig.…”

Section: Solubility Determinationsupporting

confidence: 92%

“…It was introduced into several biomaterials and drugs because of good immunogenicity and the ability of preserving the biological properties of proteins. PEGylation of chitosan (Ganji & Abdekhodaie, 2008;Jeong, Kim, Jang, & Nah, 2008;Sugimoto, Morimoto, Sashiwa, Saimoto, & Shigemasa, 1998), poly(lactic acid) (Huh & Bae, 1999) and alginate (Laurienzo, Malinconico, Motta, & Vicinanza, 2005) to improve their solubility, gelation ability or stability have been reported. This study describes the synthesis and characterization of a carboxymethyl KGM grafted monomethoxy PEG (CKGM-g-mPEG) 0144-8617/$ -see front matter Ó copolymer with grafted PEG oligomers on the high molecular weight KGM.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Xia

Meng

et al. 2010

Carbohydrate Polymers

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Section: Solubility Determinationsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Xia

Meng

et al. 2010

Carbohydrate Polymers

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“…Additionally, partially acetylated chitosan, which has about 50% D-glucosamine units, is only able to dissolve in water (Sugimoto et al, 1998). Chain flexibility of chitosan molecules in solution can be manipulated by using chitosan with different DDs, or solutions with differing pH and/or ionic strength to control the pore size, mechanical strength or permeability of the membranes or capsuleprepared chitosan (Tsaih and Chen, 1997).…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Cu(II) and Cr(VI) ions by chitosan: kinetics and equilibrium studies

Schmuhl¹,

Krieg²,

Keizer³

2004

WSA

204

170

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The ability of chitosan as an adsorbent for Cu (II) and Cr (VI) ions in aqueous solution was studied. The experiments were done as batch processes. Equilibrium studies were done on both cross-linked and non-cross-linked chitosan for both metals. Cr (VI) adsorption behaviour could be described using the Langmuir isotherm over the whole concentration range of 10 to 1000 mg·l -1 Cr. The maximum adsorption capacity for both types of chitosan was found to be 78 mg·g -1 for the non-cross-linked chitosan and 50 mg·g -1 for the cross-linked chitosan for the Cr (VI) removal. For the Cu (II) removal the Freundlich isotherm described the experimental data over the whole concentration range of 10 to 1000 mg·l -1 Cu (II). The maximum adsorption capacity for both types of chitosan can be estimated to be greater than 80 mg·g -1 . Cr (VI) removal was the highest at pH 5 but pH did not have a large influence on Cu (II). From these results it is clear that the adsorption of heavy metals is possible with chitosan, but that with this method, end concentrations of below 1 mg·l -1 can hardly be obtained.

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“…Despite these proven properties, the application of chitosan by mouth rinses or dentifrices is limited by its insolubility in water. Recently, many studies have been conducted to increase its solubility so as to broaden its spectrum of applications (8,(13)(14). Water-soluble derivatives of chitosan, obtained by replacing N-alkyl groups with disaccharides, have displayed significant anti-bacterial activity against Escherichia coli and Staphylococcus aureus (9).…”

mentioning

confidence: 99%

Antibacterial Activity and Anti-Biofilm Effect of Chitosan against Strains of Streptococcus Mutans Isolated in Dental Plaque

Pasquantonio

Greco

Prenna

et al. 2008

Int J Immunopathol Pharmacol

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Streptococcus mutans is the major cause of dental plaque and is often associated with biofilm formation. The aim of this study is to evaluate the activity of a hydrosoluble derivative of chitosan against S. mutans biofilms in vitro and in vivo. Strains of S. mutans were isolated from the dental plaque of 84 patients enrolled in the study. The antibacterial activity of chitosan was determined by broth microdilutions. The effect of chitosan at different concentrations and exposure times on S. mutans biofilms at different phases of development was assessed by a clinical study using the classical "4-day plaque regrowth" experiment in adult volunteers. The MIC values of chitosan were between 0.5 and 2 giL. Compared to distilled water, the chitosan solution significantly decreased the vitality of plaque microflora (p~0.05). Chlorhexidine, used as a positive control, reduced vitality even further. The results showed that S. mutans in the adhesion phase (4 h) was completely inhibited by chitosan at any concentration (0.1, 0.2, 0.5XMIC) or exposure time investigated (1, 15, 30, 60 min), while S. mutans at successive stages of accumulation (12-24 h) was inhibited only by higher concentrations and longer exposure times. These data confirm the effective action of chitosan against S. mutans biofilms.

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Preparation and characterization of water-soluble chitin and chitosan derivatives

Cited by 320 publications

References 20 publications

Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Preparation and characterization of a poly(ethylene glycol) grafted carboxymethyl konjac glucomannan copolymer

Adsorption of Cu(II) and Cr(VI) ions by chitosan: kinetics and equilibrium studies

Antibacterial Activity and Anti-Biofilm Effect of Chitosan against Strains of Streptococcus Mutans Isolated in Dental Plaque

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