Preparation and characterization of zein/chitosan complex for encapsulation of α-tocopherol, and its in vitro controlled release study

Luo, Yangchao; Zhang, Boce; Whent, Monica; Yu, Liangli; Wang, Qin

doi:10.1016/j.colsurfb.2011.02.020

Cited by 577 publications

(258 citation statements)

References 38 publications

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“…The low degree of encapsulation that resulted for lipophilic drugs disagrees with other scientific investigations, even though zein does contain many hydrophobic moieties. 39 This finding could be explained by the presence of high levels of xanthophylls strongly bound to yellow zein, thus inducing low EE values of lipophilic drugs with respect to decolorized zein. 11 Conversely, the zein nanoparticles were able to retain a significant amount of the hydrophilic compound, thus evidencing their potential application as a useful carrier for water-soluble drugs (Table 5).…”

Section: Drug Entrapment Efficiencymentioning

confidence: 99%

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Gagliardi¹,

Paolino²,

Iannone³

et al. 2018

IJN

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Background The use of biopolymers is increasing in drug delivery, thanks to the peculiar properties of these compounds such as their biodegradability, availability, and the possibility of modulating their physico-chemical characteristics. In particular, protein-based systems such as albumin are able to interact with many active compounds, modulating their biopharmaceutical properties. Zein is a protein of 20–40 kDa made up of many hydrophobic amino acids, generally regarded as safe (GRAS) and used as a coating material. Methods In this investigation, zein was combined with various surfactants in order to obtain stable nanosystems by means of the nanoprecipitation technique. Specific parameters, eg, temperature, pH value, Turbiscan Stability Index, serum stability, in vitro cytotoxicity and entrapment efficiency of various model compounds were investigated, in order to identify the nanoformulation most useful for a systemic drug delivery application. Results The use of non-ionic and ionic surfactants such as Tween 80, poloxamer 188, and sodium deoxycholate allowed us to obtain nanoparticles characterized by a mean diameter of 100–200 nm when a protein concentration of 2 mg/mL was used. The surface charge was modulated by means of the protein concentration and the nature of the stabilizer. The most suitable nanoparticle formulation to be proposed as a colloidal drug delivery system was obtained using sodium deoxycholate (1.25% w/v) because it was characterized by a narrow size distribution, a good storage stability after freeze-drying and significant feature of retaining lipophilic and hydrophilic compounds. Conclusion The sodium deoxycholate-coated zein nanoparticles are stable biocompatible colloidal carriers to be used as useful drug delivery systems.

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Section: Drug Entrapment Efficiencymentioning

confidence: 99%

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Gagliardi¹,

Paolino²,

Iannone³

et al. 2018

IJN

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“…Freezing exerts a substantial destabilizing stress on nanoparticles resulting in two phases of separation; one which contains ice and another concentrated viscous phase containing the nanostructures and other formulation constituents. This high particulate concentration, together with the ice crystals, may lead to aggregation, and in some cases, an irreversible fusion of nanoparticles [38,39].…”

Section: Drug Release Studiesmentioning

confidence: 99%

Self-Assembled Chitosan Nanoparticles for Percutaneous Delivery of Caffeine: Preparation, Characterization and in Vitro Release Studies

et al. 2018

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Objective: Chitosan (CS)-tripolyphosphate (TPP)-nanoparticles (NPs) have been extensively studied during the past few decades due to their wellrecognized applicability in various fields. The present study attempts to optimise the development of these nanoparticles to enhance the percutaneous delivery of caffeine.Methods: CS-TPP-NPs were prepared via ionic cross-linking of CS and TPP and were characterized. The influence of several formulation conditions (CS: TPP mass ratio and concentration of caffeine) and process parameters (stirring speed, stirring time and ultra-sonication time) on the colloidal characteristics of CS-TPP-NPs were investigated and the resulting nanoparticles were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) and x-ray diffraction (XRD) analyses. Physicochemical properties, including particle size, zeta potential and polydispersity index (PDI) were examined, and in vitro release studies were conducted to ascertain the release profile of caffeine from the nanoparticles. In addition, the colloidal stability of the prepared NPs was also assessed on storage.Results: Process parameters appeared to exert a significant effect on the physicochemical characteristics of the CS-TPP-NPs. The CS-TPP-NPs prepared under optimum conditions (CS concentration of 0.2 mg/ml, CS: TPP volume ratio of 25:12 ml, stirred at 700 rpm for 60 min, with 0.97 mg/ml caffeine concentration and treatment with low ultra-sonication for 30 min) had shown a mean particle size of ~143.43±1.69 nm, zeta potential of+43.13±1.10 mV, PDI of ~0.30±0.01. A drug loading capacity and encapsulation efficiency of 48.89% and 60.69%, respectively, were obtained. Cumulative release study for drug-loaded CS-NPs was significantly (p<0.001, paired t-test) higher (58.7% caffeine released) compared to control formulation (41.5% caffeine released) after 72 h. Stability studies conducted for 28 d showed that caffeine-loaded CS-NPs degraded much quicker when stored at 25 ⁰C than 4 ⁰C. It was also noted that caffeine-loaded CS-NPs in the freeze-dried form were unstable as the surface charge of nanoparticles dropped from positive zeta potential to-3.55 mV within 2 d at 4 ⁰C and at 25 ⁰C, surface charge dropped to-3.16 mV within 14 d of the experiment. Conclusion:Chitosan (CS)-tripolyphosphate (TPP)-nanoparticles (NPs) appear to be a promising strategy to achieve sustained percutaneous delivery of caffeine.

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“…CS has a special feature of being able to adhere to nasal mucosal surface for prolonged periods of time due to mucoadhesive property and improve drug absorption by delaying mucociliary clearance. It also transiently opens tight junctions between epithelial cells and enhances absorption, due to its positive surface charge [13]. Bromocriptine (BRC), an ergot derivative with dopamine receptor agonist activity, has been widely used clinically to delay and minimise the deleterious motor fluctuations associated with long-term levodopa treatment in PD.…”

Section: Introductionmentioning

confidence: 99%

Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

Shadab

Haque

Fazil

et al. 2014

Expert Opinion on Drug Delivery

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Preparation and characterization of zein/chitosan complex for encapsulation of α-tocopherol, and its in vitro controlled release study

Cited by 577 publications

References 38 publications

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Self-Assembled Chitosan Nanoparticles for Percutaneous Delivery of Caffeine: Preparation, Characterization and in Vitro Release Studies

Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

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