Preparation and comparison of spray dried and electrospun bioresorbable drug delivery systems

Abstract

a b s t r a c tTwo continuous processes, the spray drying method, producing microparticles in presence of hot gas flow, and the electrospinning technology, producing continuous polymer nanofibers at low temperature under high electric fields, were investigated and compared the first time. Both techniques were used to prepare slow release caffeine (as a model of rapidly water-soluble drug) using water-insoluble, biocompatible and bioresorbable PLGA and PLA as polymeric matrix. The structural characterization of the obtained samples was performed using SEM, XRD, DSC and at-line Raman mapping, while in vitro dissolution was detected by UV spectrophotometer. We found that the release profile of a highly water soluble drug can be adjusted to the requirements through the investigated continuous technologies. Solid molecular dispersion of caffeine at colloidal level could be prepared in PLA matrix using electrostatic spinning. Furthermore the continuous nonwoven structure of ultrafine fibers, produced this way, allows easer handling than that of independent fine particle's. On the other hand continuous production of drug loaded microspheres with slightly less performance can be performed with the conventional technology of spray drying which is well known in the pharmaceutical industry.

Comparison of spray drying, electroblowing and electrospinning for preparation of Eudragit E and itraconazole solid dispersions

“…The mixing level of polymer and ITR molecules remained high when electrostatic field was applied during the drying process. It corresponds to our recently published results (Sóti et al, 2015). The quantitative DSC data (table 4), in accordance with the XRPD diffraction patterns (figure 2), confirm that the samples were free of any crystal clusters after production.…”

Incorporating small molecules or biologics into nanofibers for optimized drug release: A review

“…Similar results have been obtained in a dissolution study of PLA-based electrospun fibres containing caffeine. In that study, the time for complete release was approximately 30 h for a drug:carrier loading of 1:1 and 30 days for the corresponding 1:10 ratio (Sóti et al, 2015). The initial dissolution rate of PCL nanofibres containing metronidazole benzoate was found to increase with increasing drug loading due to the higher drug concentration on the near-surface phase of the fibres (Zamani et al, 2010).…”

“…Meanwhile, for diffusion-controlled systems, the wetting and swelling behaviour of the carrier determines the liberation of the drug. The drug release rate of PLA is lower than that of PLGA because of the slower degradation rate of the lactide unit (Fathi-Azarbayjani and Chan, 2010; Sóti et al, 2015). The time required for the complete release of ibuprofen from PLGA electrospun mats is approximately 12 days.…”

“…The incorporation of a drug into a polymeric phase could result in drug release demonstrating zero-order kinetics from 200 min (Zeng et al, 2005b) even up to 60 h (Zeng et al, 2005b) and sustained release of actives over a period of at least 30 days (Sóti et al, 2015;Xu et al, 2011).…”

Electrospun polylactic acid and polyvinyl alcohol fibers as efficient and stable nanomaterials for immobilization of lipases

“…First, enzyme-free PLA membrane was prepared (as described in ''Lipase entrapment by electrospinning'' section and [26]) and freshly prepared lipase solution in sodium phosphate buffer (1 mL, buffer: pH 7.5, 100 mM, crude lipase powder concentration: 5 mg mL -1 ) was poured onto the enzyme-free PLA membrane (45 mg) and shaken at 4°C for 24 h. The resulted membrane-adsorbed lipase was washed twice with 2-propanol (2 mL) and once with n-hexane (2 mL). Finally, the membrane was dried at room temperature for 2 h. Details of the samples prepared by adsorption technique are given in Table 1.…”