Preparation and Comprehensive Characterization of [Hg6(Alanine)4(NO3)4]·H2O

Saunders, Cheryl D. L.; Burford, Neil; Werner‐Zwanziger, Ulrike; McDonald, Robert

doi:10.1021/ic702321d

Cited by 23 publications

(13 citation statements)

References 51 publications

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“…However, in some cases coordination of the α-carboxylate group to the metal ions can occur either through bi-or tri-dentate bridging modes creating extended frameworks. [7] One-dimensional coordination networks are commonly formed when pure amino acids are used however, [68] 2-and 3-dimensional MOFs can also be constructed. In the case of 2-dimensional metal-ion amino acids frameworks, a typical µ2-O1:O2 coordination mode can be obtained with glycine (Gly) and Ni II (Table 1, entry 1), [69] Mn II , [70] and Co II .…”

Section: Ligand Design In Mofsmentioning

confidence: 99%

Biologically derived metal organic frameworks

Anderson

Stylianou

2017

Coordination Chemistry Reviews

144

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Metal organic frameworks (MOFs) are extended structures composed of a network of organic ligands and metal ions or clusters connected to each other via coordination bonds. The numerous choices of organic ligands and metal coordination geometries have led to the construction of porous MOFs with various compositions, network topologies, pore sizes and shapes and they possess high surface areas and low densities. The structures of MOFs can be tailor-tuned in such a way that any desired ligand or/and metal ion can be incorporated; this has given to researchers the advantage of designing MOFs for a targeted application. Within this review, we overview recent examples of a sub-class of MOFs namely biologically derived MOFs (bio-MOFs), made of multifunctional and commercially available biologically derived ligands (bio-ligands) such as: amino acids, peptides, nucleobases and saccharides and focus on their coordination chemistry with a variety of metals. Central to this review are four tables detailing the coordination modes of bio-ligands to metals, along with a visual representation of the bio-MOF that is subsequently formed. Through the detail analysis of these structures, we highlight the structural impact of these ligands on the structure, and their contribution to the MOFs properties and applications. Finally, we showcase the potential of bio-MOFs in several research areas such as CO2 capture, separation, catalysis, drug delivery and sensing.

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Section: Ligand Design In Mofsmentioning

confidence: 99%

Biologically derived metal organic frameworks

Anderson

Stylianou

2017

Coordination Chemistry Reviews

144

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“…When this occurs, extended metal ion-AA frameworks can be created. To date, 1-D coordination networks 5 based on pure AAs are more common than 2-D or 3-D extended structures. 6-14 2-D metal ion-AA frameworks have been obtained, for example, when glycine (Gly) coordinates to metal ions (e.g.…”

Section: Introductionmentioning

confidence: 99%

Metal–biomolecule frameworks (MBioFs)

et al. 2011

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“…Biomolecules generally contain several reactive chemical groups that can coordinate with inorganic metals. So far, amino acids [ 71 ], peptides [ 72 , 73 ], nucleobases [ 74 ], and saccharides [ 75 ] have been applied as the organic ligands to synthesize bio-MOFs. Bio-MOFs tend to have better biocompatibility and special biological functionality.…”

Section: Functionalization For Drug Deliverymentioning

confidence: 99%

Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

et al. 2020

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Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. In this review, the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section. Then, state-of-the-art strategies to functionalize MOFs with therapeutic agents were summarized, including surface adsorption, pore encapsulation, covalent binding, and functional molecules as building blocks. In the third section, the most recent biological applications of MOFs for intracellular delivery of drugs, proteins, and nucleic acids, especially aptamers, were presented. Finally, challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems.

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Preparation and Comprehensive Characterization of [Hg₆(Alanine)₄(NO₃)₄]·H₂O

Cited by 23 publications

References 51 publications

Biologically derived metal organic frameworks

Biologically derived metal organic frameworks

Metal–biomolecule frameworks (MBioFs)

Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

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