Preparation and controlled degradation of oxidized sodium alginate hydrogel

Gao, Chunmei; Liu, Mingzhu; Chen, Jun; Zhang, Xu

doi:10.1016/j.polymdegradstab.2009.05.011

Cited by 148 publications

(87 citation statements)

References 24 publications

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“…Alginate: Alginate, a water-soluble linear polymer obtained from brown algae, is composed of (1-4)-β-D-mannuronic acid (M) and (1-4)-α-L-guluronic acid (G) units in the form of homopolymeric (MM-or GG-blocks) and hetero-polymeric sequences (MG-or GM-blocks) [145]. The degradation kinetics of alginate is controlled by varying molecular weight, chemical structure and crosslinking.…”

Section: Others Polymersmentioning

confidence: 99%

Controlled biodegradation of polymers using nanoparticles and its application

Kumar

Maiti

2016

RSC Adv.

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The disposal of non-degradable plastics is augmented exponentially as a result of poor recycling efficacy. The development of biodegradable plastics has become indispensable in last two decades because of its origin from renewable resources. The potential interest in biodegradable plastics involves eco-friendly obliteration via microbial action which transform into carbon dioxide and water resulting pollution free natural system. Even though its lucrative interest lies in multiple areas, some of the properties such as brittleness, poor thermal, mechanical and low gas barrier properties restrict their practical uses. Incorporation of nanoparticle in polymer matrix or by making nanocomposites overcomes the shortcomings of the biodegradable polymers. For further improving the aforementioned properties, several approaches have been utilized especially incorporation of nanoparticle in polymer matrix to prepare nanocomposites. One of the great advantages of nanoparticles is to tune the rate of biodegradation (both increase and decrease as compared to the rate of pure polymer) depending upon the need. Thus, chemical, physical and biological properties of the biodegradable polymers can be modified and controlled for sustainable application in medical and other areas. This review considers the major concerns about the type of biodegradable polyesters and their nanocomposites, great details about mechanism of biodegradation, factors influencing the biodegradation and their applications in biomedical and packaging industries.

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Section: Others Polymersmentioning

confidence: 99%

Controlled biodegradation of polymers using nanoparticles and its application

Kumar

Maiti

2016

RSC Adv.

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“…An additional challenge for alginate hydrogels in vivo is that the alginate macromolecule itself is difficult to break down under physiological conditions, and the molecular weight of released alginate strands is typically above the renal clearance threshold. 107, 108 However, partially oxidized alginate, which undergoes biodegradation, can be utilized to overcome these limitations. 109 …”

Section: Materials For Hydrogel Preparationmentioning

confidence: 99%

Designing degradable hydrogels for orthogonal control of cell microenvironments

2013

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“…These preliminary studies also allowed to state that AC hydrogels can be injected into spinal cord parenchyma for local therapies achieving in situ gelation that is an essential feature for regenerative medicine. 23 The aim of the present work was to study the degradation of AC hydrogels and its fine control 24,25 : it was monitored via Fourier transform infrared (FT-IR) spectroscopy measurements, by differential scanning calorimetry (DSC) analysis, and % mass loss. 24,26,27 Moreover, the hydrogel inner morphology and its nanometric nature were investigated by transmission electron microscopy (TEM).…”

Section: Introductionmentioning

confidence: 99%

“…23 The aim of the present work was to study the degradation of AC hydrogels and its fine control 24,25 : it was monitored via Fourier transform infrared (FT-IR) spectroscopy measurements, by differential scanning calorimetry (DSC) analysis, and % mass loss. 24,26,27 Moreover, the hydrogel inner morphology and its nanometric nature were investigated by transmission electron microscopy (TEM). As described, 20 AC gels can be considered a ''material library,'' and thus, investigations were here performed only on AC1 and AC6 samples, because they represent the two limits, lower and upper, respectively, of the explored crosslinkers ratios range.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and degradation of agar‐carbomer based hydrogels for tissue engineering applications

Rossi

Chatzistavrou

Perale

et al. 2011

J of Applied Polymer Sci

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Hydrogels studied in this investigation, synthesized starting from agarose and Carbomer 974P, were chosen for their potential use in tissue engineering. The strong ability of hydrogels to mimic living tissues should be complemented with optimized degradation time profiles: a critical property for biomaterials but essential for the integration with target tissue. In this study, chosen hydrogels were characterized both from a rheological and a structural point of view before studying the chemistry of their degradation, which was performed by several analysis: infrared bond response [Fourier transform infrared (FT-IR)], calorimetry [differential scanning Calorimetry (DSC)], and % mass loss. Degradation behaviors of Agar-Carbomer hydrogels with different degrees of crosslinkers were evaluated monitoring peak shifts and thermal property changes. It was found that the amount of crosslinks heavily affect the time and the magnitude related to the process. The results indicate that the degradation rates of Agar-Carbomer hydrogels can be controlled and tuned to adapt the hydrogel degradation kinetics for different cell housing and drug delivery applications.

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Preparation and controlled degradation of oxidized sodium alginate hydrogel

Cited by 148 publications

References 24 publications

Controlled biodegradation of polymers using nanoparticles and its application

Controlled biodegradation of polymers using nanoparticles and its application

Designing degradable hydrogels for orthogonal control of cell microenvironments

Synthesis and degradation of agar‐carbomer based hydrogels for tissue engineering applications

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