Preparation and crystal structure determination of adducts of copper(II) chloride with 3-aryl-1-(imino-pyridin-2-yl-methyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles

Bonacorso, Hélio G.; Lang, Ernesto Schulz; Lewandowski, Hilario; Martins, Marcos A. P.; Peppe, Clóvis; Zanatta, Nilo

doi:10.1016/s1387-7003(03)00073-x

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Cited by 8 publications

References 7 publications

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Amidrazones as Precursors of Biologically Active Compounds – Synthesis of Diaminopyrazoles for Evaluation of Anticancer Activity

Cocco¹,

Congiu

Lilliu

et al. 2006

Archiv der Pharmazie

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The regioselectivity of coupling phenyl isocyanate to 3-(2-acylhydrazino)-3-aminopropenenitriles and ethyl 3-(2-acylhydrazino)-3-aminopropenoates as simple access to aminopyrazole derivatives, endowed with potential antitumoral activity, is reported. 3-(2-Acylhydrazino)-3-aminopropenenitriles react with phenyl isocyanate to afford 3-amino-3-(2-acylhydrazino)-2-phenylaminocarbonyl-2-propenenitriles. These key intermediates were cyclized into 3,5-diaminopyrazole-4-carboxamide derivatives. Preliminary results of poor antiproliferative activities of these compounds are also reported.

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Amidrazones as Precursors of Biologically Active Compounds – Synthesis of Diaminopyrazoles for Evaluation of Anticancer Activity

Cocco¹,

Congiu

Lilliu

et al. 2006

Archiv der Pharmazie

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Regiospecific one-pot synthesis of new trifluoromethyl substituted heteroaryl pyrazolyl ketones

Bonacorso

Oliveira

Costa

et al. 2005

Journal of Heterocyclic Chemistry

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Regiospecific synthesis of trichloromethyl substituted 4,5‐dihydro‐1h‐1‐tosylpyrazoles

Bonacorso

Wentz

Lourega

et al. 2007

Journal of Heterocyclic Chem

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The regiospecific synthesis of a new series of eight 3‐alkyl(aryl)‐5‐hydroxy‐5‐trichloromethyl‐4,5‐dihydro‐1H‐1‐tosylpyrazoles is reported. The 1‐p‐tosyl‐2‐pyrazolines were obtained from the cyclocondensation reaction of 4‐alkyl(aryl)‐4‐alkoxy‐1,1,1‐trichloroalk‐3‐en‐2‐ones, [where alkyl = H, Me and aryl = ‐C6H5, 4‐CH3C6H4, 4‐OCH3C6H4, 4‐FC6H4, 4‐ClC6H4, 4‐BrC6H4,] with p‐tosylhydrazine in 64 to 92 % yields, employing anhydrous toluene at reflux or diethyl ether at room temperature as the reaction condition.

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Preparation and crystal structure determination of adducts of copper(II) chloride with 3-aryl-1-(imino-pyridin-2-yl-methyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles

Cited by 8 publications

References 7 publications

Amidrazones as Precursors of Biologically Active Compounds – Synthesis of Diaminopyrazoles for Evaluation of Anticancer Activity

Amidrazones as Precursors of Biologically Active Compounds – Synthesis of Diaminopyrazoles for Evaluation of Anticancer Activity

Regiospecific one-pot synthesis of new trifluoromethyl substituted heteroaryl pyrazolyl ketones

Regiospecific synthesis of trichloromethyl substituted 4,5‐dihydro‐1h‐1‐tosylpyrazoles

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