Preparation and drug-delivery study of functionalized hydroxyapatite based on natural polysaccharide gums with excellent drug-loading properties

Tian, Chao; Xu, Pengfei; Jiang, Jianxin; Han, Chunrui

doi:10.1080/01932691.2019.1710185

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…The pristine TMGA hydrogel spectrum is depicted in Figure 1 B, with peaks observed at 1729.52 cm −1 and 1612.95 for (acid/amide) -C=O stretching vibration. The broad peak for TMG’s -O-H bending vibration was recorded at 1380.95 cm −1 [ 29 , 30 ]. Furthermore, peaks for P-O, P=O, and -C-O-C stretching vibrations emerged at 1216.19 and 1053 cm −1 , confirming the existence of phosphate crosslinker (BMEP).…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Nagaraja

Rao

et al. 2021

Gels

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In this paper, novel pH-responsive, semi-interpenetrating polymer hydrogels based on tamarind gum-co-poly(acrylamidoglycolic acid) (TMGA) polymers were synthesized using simple free radical polymerization in the presence of bis[2-(methacryloyloxy)ethyl] phosphate as a crosslinker and potassium persulfate as a initiator. In addition, these hydrogels were used as templates for the green synthesis of silver nanoparticles (13.4 ± 3.6 nm in diameter, TMGA-Ag) by using leaf extract of Teminalia bellirica as a reducing agent. Swelling kinetics and the equilibrium swelling behavior of the TMGA hydrogels were investigated in various pH environments, and the maximum % of equilibrium swelling behavior observed was 2882 ± 1.2. The synthesized hydrogels and silver nanocomposites were characterized via UV, FTIR, XRD, SEM and TEM. TMGA and TMGA-Ag hydrogels were investigated to study the characteristics of drug delivery and antimicrobial study. Doxorubicin hydrochloride, a chemotherapeutic agent successfully encapsulated with maximum encapsulation efficiency, i.e., 69.20 ± 1.2, was used in in vitro release studies in pH physiological and gastric environments at 37 °C. The drug release behavior was examined with kinetic models such as zero-order, first-order, Higuchi, Hixson Crowell and Korsmeyer–Peppas. These release data were best fitted with the Korsemeyer–Peppas transport mechanism, with n = 0.91. The effects of treatment on HCT116 human colon cancer cells were assessed via cell viability and cell cycle analysis. The antimicrobial activity of TMGA-Ag hydrogels was studied against Staphylococcus aureus and Klebsiella pneumonia. Finally, the results demonstrate that TMGA and TMGA-Ag are promising candidates for anti-cancer drug delivery and the inactivation of pathogenic bacteria, respectively.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Nagaraja

Rao

et al. 2021

Gels

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“…Guar gum-mediated HAp has an outstanding drugloading capacity of 236.18 mg g À1 and drug loading efficiency of up to 74.79%. 175 The treatment of cancer cells may be viable by using biosynthesized hydroxyapatite nanoparticles. The pectin-based nano-HAp reveals a dose-dependent cytotoxicity towards prostate cancer cells (PC3 cells).…”

Section: Nature Of Templating Agents and Possible Applications Of Resmentioning

confidence: 99%

A plant-mediated synthesis of nanostructured hydroxyapatite for biomedical applications: a review

2020

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Fabrication of Biologically Active Fish Bone Derived Hydroxyapatite and Montmorillonite Blended Sodium Alginate Composite for In-Vitro Drug Delivery Studies

Ahamed

Manimohan

Kalaivasan

2022

J Inorg Organomet Polym

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Fishbone comprising hydroxyapatite (bio-ceramic) is regularly viewed as a natural resource for biological and pharmaceutical applications. In this study, hydroxyapatite has been prepared from shbone waste using thermal calcination method. The composite hydroxyapatite-montmorillonite-sodium alginate was synthesized by co-precipitation method. Various functional groups of biocomposite were characterised using Fourier Transform infrared spectroscopy (FT-IR). Thermal gravimetric analysis (TGA) and X-ray diffraction studies were exhibited the thermal stability and crystallinity of biocomposite respectively. The morphological surface of composites was studied using scanning electron microscopy (SEM). The synthesized composite was designed to study the enhanced biological potential such as antibacterial, antioxidant, antidiabetic, drug loading and the drug releasing ability. Antioxidant and anti-diabetic analysis of composite were studied using Phosphomolybdenum and α-Amylase inhibitory method respectively. The drug releasing ability of compounds (Doxorubicin and Curcumin) were investigated by UV-spectrophotometry method at different pH medium (pH = 5.5, 6.8 and 7.4). Additionally, In-vitro kinetic studies were carried out on composite to determine the drug releasing ability of doxorubicin and curcumin.

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Preparation and drug-delivery study of functionalized hydroxyapatite based on natural polysaccharide gums with excellent drug-loading properties

Cited by 5 publications

References 35 publications

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

Synthesis of Novel Tamarind Gum-co-poly(acrylamidoglycolic acid)-Based pH Responsive Semi-IPN Hydrogels and Their Ag Nanocomposites for Controlled Release of Chemotherapeutics and Inactivation of Multi-Drug-Resistant Bacteria

A plant-mediated synthesis of nanostructured hydroxyapatite for biomedical applications: a review

Fabrication of Biologically Active Fish Bone Derived Hydroxyapatite and Montmorillonite Blended Sodium Alginate Composite for In-Vitro Drug Delivery Studies

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