Preparation and evaluation of a chitosan salt–poloxamer 407 based matrix for buccal drug delivery

Cafaggi, Sergio; Leardi, Riccardo; Parodi, Brunella; Caviglioli, Gabriele; Russo, Eleonora; Bignardi, Gaetano

doi:10.1016/j.jconrel.2004.09.019

Cited by 57 publications

(38 citation statements)

References 18 publications

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“…Chitosan showed the highest adhesive force, also the distance to separate the bioadhesive film from the naked rat skin was large; therefore, the work of adhesion was markedly high. According to one of theories, hydration of the polymer causes mobilization of the polymer chains and hence influences polymeric adhesion (18,19). The adequate water absorption capacity together with the cationic nature which promote binding to the negative surface of the skin (20) can interpret the good adhesion behavior of chitosan.…”

Section: Bioadhesion Testmentioning

confidence: 99%

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Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part II: Biological Evaluation

et al. 2009

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Abstract. This study is an extrapolation of our previous one (part I) concerned with the formulation and physicochemical evaluation of a novel, simple, monolayer, easy-to-use, cost-effective, and aesthetically acceptable bioadhesive transdermal patch for tramadol hydrochloride. The current work is focused on bioadhesion, skin tolerability, and pharmacodynamic evaluation. Using naked rat skin, chitosanEudragit® NE30D (1:1) film attained best bioadhesive properties. During in vivo studies, it also showed a significantly extended analgesic effect compared to both oral formula and chitosan single polymeric film using the hot plate test method. All the polymeric films were skin tolerable for the intended period of application according to the Draize test. The success of our approach can proudly, positively contribute into the world of pain management and arguably push transdermal delivery to realize its great promise.

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Section: Bioadhesion Testmentioning

confidence: 99%

“…The adequate water absorption capacity together with the cationic nature which promote binding to the negative surface of the skin (20) can interpret the good adhesion behavior of chitosan. The plasticizer glycerin can also enhance bioadhesion (18).…”

Section: Bioadhesion Testmentioning

confidence: 99%

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part II: Biological Evaluation

et al. 2009

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“…[25] Studies have shown that chitosan can enhances absorption of hydrophilic molecules by rearrangement of protein structures associated to the intercellular junctions. [61,62] Chitosan binds to the mucosa via ionic bonds between the amino group and sialic acid residues.…”

Section: Chitosanmentioning

confidence: 99%

A Systematic Review on Mucoadhesive Drug Delivery System

Tandel¹

2017

WJPR

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The prospect of writing this review article is to present comprehensive information related to mucoadhesion and mucoadhesive drug delivery systems. The article has highlighted all the aspects of mucoadhesive drug delivery systems which will be helpful for researches and academics. The article includes detailed information about mucosa-the anatomy and physiology, the mechanisms and theories related to mucoadhesion, evaluation parameters of mucoadhesive dosage forms, mucoadhesive polymers and novel approaches related to mucoadhesive drug delivery system. The potential merits and demerits of mucoadhesive drug delivery as well as that of the polymers are also discussed.

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“…Chitosan film showed the highest water uptake capacity (MSI=709.69%±40.15); chitosan is a hydrophilic polymer, of which NH 2 and OH groups have the ability to interact with water molecules (38). Also, the swelling of chitosan may be favored by the presence of lactic acid used as solvent for chitosan and glycerin used as plasticizer (55).…”

Section: Swelling and Water Uptake Studiesmentioning

confidence: 99%

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part I: Physicochemical Evaluation

et al. 2009

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Abstract. Management of moderate or severe chronic pain conditions is the burden of clinicians dealing with patients trying to improve their quality of life and diminish their suffering. Although not a new opioid, tramadol has been recently rediscovered and widely used; this may be due to its favorable chronic safety and dependence profiles together with its high potency. Tramadol is a centrally acting analgesic with half-life of~6 h; therefore, it requires frequent dosing. It is freely soluble in water; hence, judicious selection of retarding formulations is necessary. The current study is focused on the innovation of a novel, simple, monolayer, easy-to-use, cost-effective, and aesthetically acceptable bioadhesive transdermal delivery system overcoming the defects of the conventional "patch" as carrier system for tramadol, ensuring its adequate delivery, along with the physicochemical evaluation of the designed formulations. Monolithic tramadol matrix films of chitosan, different types of Eudragit ® , and binary mixtures of both were prepared. As a single-polymer film, chitosan film showed best properties except for somewhat high moisture uptake capacity, insufficient strength and rapid release, and permeation. Polymer blends were monitored in order to optimize both properties and performance. Promising results were obtained, with chitosan-Eudragit ® NE30D (1:1) film showing the most desirable combined, sufficiently rapid as well as prolonged release and permeation profiles along with satisfactory organoleptic and physicochemical properties.

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Preparation and evaluation of a chitosan salt–poloxamer 407 based matrix for buccal drug delivery

Cited by 57 publications

References 18 publications

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part II: Biological Evaluation

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part II: Biological Evaluation

A Systematic Review on Mucoadhesive Drug Delivery System

Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part I: Physicochemical Evaluation

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