Preparation and evaluation of a UV-curing hydrophilic semi-IPN coating for medical guidewires

Ding, Wenfei; Zhao, Zheng; Jiang, Lingmei; Jian, Xigao; Yuan, Songmei; Wang, Jinyan

doi:10.1007/s11998-020-00455-9

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…This is because hydrophilic polymers easily break and penetrate the surface (Zhou et al 2018). Therefore, most PVP coated wires are less stable and do not produce desired results for biomedical purposes (Ding et al, 2021).…”

Section: Literature Reviewmentioning

confidence: 99%

Studying and Troubleshooting Lubricity Test on Pressure Guidewire Proximal and Distal Coatings

Agarwal,

A. Khan

2023

Proceedings of the International Conference on Industrial Engineering and Operations Management

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Coatings of guidewires used in medical device manufacturing industry are one of the most important aspects. It defines its efficiency to penetrate through tightest of canals and curves. Guidewires are put through controlled environment to accelerate its age and tested for its mechanical features. Pressure Guidewire failed the lubricity testing after being tested by multiple operators and at alternate sites. A cause-and-effect diagram shows all potential causes of test failure. The human factor involved in the test failure was investigated through multiple Gage R&R and training records. Calibration error with the lubricity tester DL1000 was identified and solved through preventive maintenance work order. The failed samples were examined under Scanning Electron Microscope and detailed images showed coating wearing off from T=2years samples. A two-factor design of experiment factorial was conducted to see the effects of factors on distal and proximal sections of the wire. The actual setting of Corona distance 5mm and Dip speed 60mm/min seem to affect the coating of proximal section during aging process. A new optimize setting of Corona distance 2mm and Dip speed of 30mm/min proved to provide better coating that can sustain the wire over the 2 years. Similarly, for distal section of Pressure Guidewire, UV intensity of 6.0 and Corona time of 30seconds showed better results as compared to original setting. A confirmation study was conducted to prove the effects of new changes implementation and process capability showed that the results were under control.

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Section: Literature Reviewmentioning

confidence: 99%

Studying and Troubleshooting Lubricity Test on Pressure Guidewire Proximal and Distal Coatings

Agarwal,

A. Khan

2023

Proceedings of the International Conference on Industrial Engineering and Operations Management

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“…The mechanical and chemical combination techniques and features of multiple polymers are of great industrial and academic significance for coating performances because they provide a useful method for modifying properties to achieve the specified application. [1][2][3][4][5] Interpenetrating polymer networks (IPNs), among the different types of polymeric mixtures, are a specific group of hybrid polymer materials comprising two thermosetting resins in which the polymer networks are physically and permanently linked together via chain entanglements, as well as chemically a few bond formations between two resins. [6][7][8][9][10][11][12] Thermosetting resins similar to vinyl ester, polyester, and especially epoxy are generally applied as coating binders.…”

Section: Introductionmentioning

confidence: 99%

The synergistic impacts of hybrid nanofillers of graphene nanoplatelets/carbon nanotubes on curing behavior of an epoxy‐vinyl ester interpenetrating polymer network nanocomposite coating

Molaei,

Jannesari

2023

Polymer Composites

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This study investigated the synergistic effects of hybrid graphene nanoplatelet (GnP)/multi walled carbon nanotube (MWCNT) nanofillers at various loadings on the kinetics of curing of the epoxy (EP)/vinyl ester (VE) interpenetrating polymer network (IPN) system, with a mass ratio of 1:1. Fourier transform infrared spectroscopy (FTIR), dynamic mechanical thermal analyzer (DMTA) and differential scanning calorimetry (DSC) were used to monitor the interpenetration process of EP and VE and likely interactions between the components of the different resin systems in IPN. The curing behavior of all prepared samples under non‐isothermal conditions was studied using DSC at four heating rates. Two different isoconversional approaches were applied to evaluate the reaction kinetics, that is, the Friedman and the advanced Vyazovkin methods. The obtained activation energy curves for all samples revealed a complex curing behavior involving three stages; early IPN stage, IPN growth stage, and late IPN stage. Then, the activation energy values for each reaction step were determined based on the Friedman method. The presence of GnP/MWCNT nanoparticles showed no catalytic effect on the reaction of VE with methyl ethyl ketone peroxide (MEKP). In contrast, incorporating GnP/MWCNT nanoparticles significantly decreases the activation energy values of the reaction of ring opening of epoxides with methyl tetrahydrophthalic anhydride (MTHPA) 1‐methyl imidazole (‐Mi) and the reaction of esterification of the hydroxyl groups of VE with MTHPA.Highlights Model‐free methods used to curing study of epoxy‐vinyl ester IPN nanocomposites FTIR, DSC and DMTA used for evaluation IPN formation of EP/VE It showed that the improvement of dispersion and compatibility by using of GnP/MWCNT hybrid Frideman and Vyazovkin methods used to calculate Ea of nanocomposites DSC thermograms were deconvoluted into three individual peaks.

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Section: Introductionmentioning

confidence: 99%

“…At present, the prevailing preparation method of hydrophilic lubricating layer commonly used for interventional medical devices is to coat the surface of devices with single or multilayers of hydrophilic polymer materials, and then cure by heat curing, ultraviolet (UV) curing, or other methods. , Among the coating methods, hydrogel coatings have a 3D cross-linked network that can absorb a large amount of water molecules, which is a promising kind of hydrophilic lubricating coating strategy. − Theoretically, hydrogels with interpenetrating networks possess strong bonding ability on diverse polymer substrates, with robust and flexible properties for medical and biological applications. − For example, Xu et al presented a universal coating scheme for medical devices called UV-triggered surface catalytically initiated radical polymerization from a sticky initiation layer (SIL@UV-SCIRP), using the copolymerization of two monomers, and it is shown that the polyvinyl chloride catheter coated with the corresponding hydrogel exhibits a stable coefficient of friction of 0.0437 in 300 cycles; notably, the scheme can efficiently modify the surface of various polymer medical devices with hydrogel coatings. Yu et al reported a tough and slippery hydrogel coating with a double network (DN) of monomer–polymer and macromolecule, and the prepared PU substrates with the DN hydrogel coating can sustain a very low coefficient of friction of 0.030 for 3000 cycles under a 2 N load; tests such as these verify the long-term lubricity of the DN hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Superhydrophilic and Antifriction Thin Hydrogel Formed under Mild Conditions for Medical Bare Metal Guide Wires

Yang,

Lin,

Shah

et al. 2023

ACS Appl. Mater. Interfaces

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Medical guide wires play a crucial role in the process of intravascular interventional therapy. However, it is essential for bare metal guide wires to possess both hydrophilic lubricity and coating durability, avoiding tissue damage caused by friction inside the blood vessel during the interventional procedure. Additionally, it is still a huge challenge for diverse metal materials to bind with polymer coatings easily. Herein, we present a hydrogel coating scheme and its preparation method for various wires under mild conditions for environmental protection purposes. The preparation process involves surface pretreatment, including lowtemperature heating and silanization, followed by a two-step dip coating and ultraviolet polymerization. The whole process leads to the formation of an interpenetrating cross-linked hydrogel network from the substrate to the surface section. This study confirms the superhydrophilicity and lubricity of three metal wires with the designed coating, especially reducing the friction significantly by ≥ 95%. The thin coating (average thickness <6.2 μm) demonstrates strong adhesion with various substrates and exhibits resistance to 25 or even 125 cycles of friction, indicating excellent stability and preventing easy detachment. The finally prepared composite nickel−titanium (NiTi) guide wire with stainless steel (SS) and platinum−tungsten (Pt−W) coils (overall diameter of ∼0.36 mm) shows satisfactory performance with a friction of 0.183 N for 25 cycles, meeting the clinical requirements (average friction ≤0.2 N) for interventional operation. These findings highlight the potential of this study in advancing the development of medical devices, particularly in the field of intravascular interventional therapy.

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Preparation and evaluation of a UV-curing hydrophilic semi-IPN coating for medical guidewires

Cited by 9 publications

References 22 publications

Studying and Troubleshooting Lubricity Test on Pressure Guidewire Proximal and Distal Coatings

Studying and Troubleshooting Lubricity Test on Pressure Guidewire Proximal and Distal Coatings

The synergistic impacts of hybrid nanofillers of graphene nanoplatelets/carbon nanotubes on curing behavior of an epoxy‐vinyl ester interpenetrating polymer network nanocomposite coating

Superhydrophilic and Antifriction Thin Hydrogel Formed under Mild Conditions for Medical Bare Metal Guide Wires

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