Preparation and Evaluation of a Herbal Uterine Tonic

Mukherjee, Pulok K.; Das, Joydeep; Balasubramanian, R.; Saha, Kashinath; Pal, Mahesh; Saha, B. P.

doi:10.1002/(sici)1099-1573(199611)10:7<619::aid-ptr911>3.0.co;2-0

Cited by 12 publications

(6 citation statements)

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“…In addition, Mukherjee et al reported that N. nucifera rhizomes possessed diverse bioactivities, including antibacterial, 10) antidiarrhoeal, 11) diuretic, 12) antifungal, 13) antipyretic, 14) anti-inflammatory, 15) and antidiabetic. 16,17) Additionally, the rhizomes have been reported to exhibit antihypertensive 18) and memory enhancing activities.…”

mentioning

confidence: 99%

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

Jung

Hyun

et al. 2010

Biological & Pharmaceutical Bulletin

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Nelumbo nucifera GAERTN., the family of Nelumbonaceae, is a perennial, rhizomatous, aquatic plant distributed throughout Asia, including India, China, and Egypt. The plant is comprised of: membranous, peltate, orbicular, and concave leaves; nut-contained and ovoid fruits; black, hard, and ovoid seeds; nodal roots. In Korea, China and India, various parts of N. nucifera have been used in foodstuffs and traditional medicine for the treatment of diarrhea, gastritis, insomnia, nervous prostration and as a haemostatic.1-3) In particular, numerous biological activities, including antioxidant, 4,5) anti-human immunodeficiency virus (HIV), 6) antihyperlipidemic, 1) hepatoprotective, and antiobesity effects [7][8][9] have been reported from the leaves of N. nucifera. In addition, Mukherjee et al. reported 24) Recently, N. nucifera semen extract was reported to improve memory in rats with scopolamine-induced dementia through the induction of choline acetyltransferase expression and inhibition of acetylcholinesterase (AChE).25) Even though individual parts of this plant have been the target of distinct biological and pharmacological research, there are limited studies of the stamens, with the exception of research focusing upon the antioxidant and rat lens aldose reductase (RLAR) inhibition [26][27][28] and anti-allergic activities 29) attributed to the flavonoids. Alzheimer's disease (AD) is a neurodegenerative disease and the most frequent and predominant cause of dementia in the elderly, provoking progressive cognitive decline, psychobehavior disturbances, memory loss, the presence of senile plaques, neurofibrillary tangles, and a decrease in cholinergic transmission. 30,31) Although the pathogenesis of AD is complicated and involved in numerous pathways, two major hypotheses are currently under consideration regarding the molecular mechanism, the cholinergic hypothesis and the amyloid cascade hypothesis. Thus, the focus herein is upon inhibitors of select cholinesterases (ChEs) to alleviate cholinergic deficits and improve neurotransmission and b-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1; aspartyl protease, b-secretase, and memapsin2) inhibitors to preclude formation and accumulation of amyloid b peptide (Ab). Pursuant to this, both could then be established as viable therapeutic targets for AD. [31][32][33][34] Given that numerous promising pharmaceuticals and nutraceuticals are constantly isolated from effective natural products, and that a previous study from this lab indicated potent antioxidant and RLAR inhibitory activities of N. nucifera stamens, this plant was chosen for ongoing investigations into anti-AD activities. The present work deals with the isolation and characterization of a new b-cyclogeraniol diglycoside (5), and four known compounds: cycloartenol (1); p-hydroxybenzoic acid (2); vanilloloside (3); 5Ј-Omethyladenosine (4). Furthermore, the inhibitory activities of 1-5 toward ChEs, including AChE and butyrylcholinesterase (BChE), and BACE1 were evaluated. Busanjin-gu, Busan 61...

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confidence: 99%

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

Jung

Hyun

et al. 2010

Biological & Pharmaceutical Bulletin

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“…The test organisms were maintained on nutrient agar slants. In vitro antibacterial activity was determined by the agar well-diffusion method as described by Mukherjee et al [38]. The overnight bacterial culture was centrifuged at 8000 rpm for 10 min.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

μ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies

et al. 2014

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(3) and dpq (4) complexes were structurally characterized by X-ray data analysis. Their DNA binding, oxidative cleavage and antibactirial activities were studied. The dpq (4) and dppz (5) complexes are avid binders to the Calf thymus DNA (CT-DNA). The phen (3), dpq (4) and dppz (5) complexes show efficient oxidative cleavage of supercoiled DNA (SC DNA) through hydroxyl radical ( Å OH) pathway in the presence of Mercaptopropionic acid (MPA).

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“…The test organisms were maintained on nutrient agar slants. In-vitro antibacterial activity was determined by the agar well-diffusion method as described by Mukherjee et al [60]. The overnight bacterial culture was centrifuged at 8000 rpm for 10 min.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Oxidative DNA cleavage, cytotoxicity and antimicrobial studies of l-ornithine copper (II) complexes

et al. 2012

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a b s t r a c tNew ternary copper (II) complexes, [Cu(L-orn)(B)(Cl)](ClÁ2H 2 O) (1-2) where L-orn is L-ornithine, B is an N,N-donor heterocyclic base, viz. 2,2 0 -bipyridine (bpy, 1) and 1,10-phenanthroline (phen, 2), were synthesized and characterized by various spectroscopic techniques. Complex 2 is characterized by the X-ray single crystallographic method. The complex shows a distorted square-pyramidal (4 + 1) CuN 3 OCl coordination sphere. Binding interactions of the complexes with calf thymus DNA (CT-DNA) were investigated by UV-Vis absorption titration, ethidium bromide displacement assay, viscometric titration experiment and DNA melting studies. Complex 2 shows appreciable chemical nuclease activity in the presence of 3-mercaptopropionic acid (MPA). The complexes were subjected to in vitro cytotoxicity studies against carcinomic human alveolar basal epithelial cells (A-549) and human epithelial (HEp-2) cells. The IC 50 values of 1 and 2 are less than that of cisplatin against HEp-2 cell lines. MIC values for 1 against the bacterial strains Streptococcus mutans and Pseudomonas aeruginosa are 0.5 mM.

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Preparation and Evaluation of a Herbal Uterine Tonic

Cited by 12 publications

References 0 publications

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

Selective Cholinesterase Inhibitory Activities of a New Monoterpene Diglycoside and Other Constituents from Nelumbo nucifera Stamens

μ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies

Oxidative DNA cleavage, cytotoxicity and antimicrobial studies of l-ornithine copper (II) complexes

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