Preparation and evaluation of antibacterial herbal mouthwash against oral pathogens

Yadav, Akshay R.; Mohite, Shrinivas K.; Magdum, C. S.

doi:10.5958/2231-5659.2020.00028.4

Cited by 15 publications

(16 citation statements)

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“…and Escherichia Coli and lower inhibitions against the two species of fungal strains which suggest that they have more comprehensive bacterial inhibitory than fungicidal activity, which may be due to the presence of the thiadiazole (N=C=S) moiety [28,29], and incorporation of some groups such as -Cl, -SO2 and -CH2Ph. These results are in agreement with previously reported results for thiadiazole derivatives [30,31].…”

Section: )supporting

confidence: 94%

“…It has been reported that 1,3,4-thiadiazole scaffolds known to be associated with diverse pharmacological activities including antimicrobial [30], anti-bacterial [31], antioxidant [32], antiinflammatory [33], anticancer [34], anti-HIV [35], antiviral [36], anti-tuberculosis [37], anticonvulsant [38], antidepressant [39], kinesin inhibitors [40], etc.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and evaluation of in vitro biological activity of new series of quinazolinone and benzoxazinone derivatives

2021

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A convenient synthesis for 1,3,4-thiadiazolyl quinazolinone derivatives is described via facile cyclization of anthranilic acid with succinic anhydride and upon reaction with glycine afforded 3-glycinyl quinazolinone derivative (2), which then treated with thiosemicarbazide and produced 1,3,4-thiadiazolyl quinazolinone derivative (3). Also, the key intermediate isothiocyanatobenzoazinone ( 13) is synthesized and checked for the synthesis of triazolyl-( 14), oxooxazolidinyl-( 15) and triazinanyl-(16a,b) benzoxazinone scaffolds by reaction with phenylhydrazine, glycine and urea and/ or thiourea, respectively.Antimicrobial activity of the synthesized compounds were evaluated against selected bacterial and fungal strains and compared with penicillin and compounds 6, 7b, 10b, 11, 14 and 16b exhibited promising activity as compared to the tested standard. The structures of the products were assigned and confirmed on the basis of their elemental analyses as well as spectral data (IR, MS and 1 H NMR).

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Section: )supporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of in vitro biological activity of new series of quinazolinone and benzoxazinone derivatives

2021

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“…Herbal mouthwashes are produced from natural substances and have fewer side effects; they also have antibacterial, antiviral, and antifungal properties; therefore, their use has become widespread in the last decade [32]. The antibacterial effect of plant extracts and herbal mouthwashes against microorganisms responsible for bacterial infection of the oral cavity is attributed to the presence of compounds such as glycosides, terpenoids, flavonoids, and saponins [33].…”

Section: Introductionmentioning

confidence: 99%

Effect of clove mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial

et al. 2023

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Objectives Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in intensive care units (ICUs), and the use of mouthwash is the most widely used method to prevent its incidence. The aim of this study was to investigate effect of clove mouthwash on the incidence of VAP in the ICU. Materials and methods This comparative, randomized, triple-blind, clinical trial was conducted on 168 eligible ICU patients at Kosar Hospital in Semnan, Iran, during 2021-2022, who were divided into intervention and control groups using random blocks. The intervention group received clove extract mouthwash at 6.66% concentration, and the control group received chlorhexidine 0.2% twice a day for 5 days (routine care). Data were collected using a demographic questionnaire, and disease severity was measured based on the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, oral health status was examined using the Beck Oral Assessment Scale (BOAS), and VAP diagnosis was made based on the Modified Clinical Pulmonary Infection Score (MCPIS). Results Before the intervention, there was no significant difference in disease severity (p = 0.412) and oral health status (p = 0.239) between the patients in the two groups. After the intervention, 20.2% of the patients in the intervention group and 41.7% of those in the control group acquired VAP. The risk of VAP was 2.06 times higher in the control group than in the intervention group (p = 0.005, 95% CI: 1.26-3.37, RR = 2.06), but the severity of VAP did not differ significantly between the patients in the two groups (p = 0.557). ConclusionThe findings showed that clove mouthwash reduces the incidence of VAP significantly. Clinical relevance Clove mouthwash can be used as a simple and low-cost method to prevent VAP in ICU patients.

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“…HIV [26], antimicrobial inflammatory [28], anti-tuberculosis [29], bacterial [30], antioxidant [31], anticancer [32], as well as CNS depressant and anticonvulsant…”

Section: New Seriesmentioning

confidence: 99%

“…A brief survey on the biological activities of 1,3,4 thiadiazole scaffolds showed antiviral [24], antidepressant [25], anti-HIV [26], antimicrobial [27], anti-inflammatory [28], anti anti-bacterial [30], antioxidant [31], anticancer [32], as well as CNS depressant and anticonvulsant [33,34].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of antibacterial and antifungal activity of new series of thiadiazoloquinazolinone derivatives.

2021

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A facile and convenient synthesis of 1,3,4 acid with maleic anhydride, which upon reaction with glycine afforded 3 with thiosemicarbazide and produced 1,3,4 (13) is used as a key compound in synthesizing of triazolyl benzoxazinoneheterocyclesby reaction with phenyl hydrazine, glycine and urea and/ or thiourea, respectively. Evaluation of antimicrobial activity of some of the synthesized compounds against selected bacteria and fungi strains in comparison with Ampicillin as antibacterial agent and Amphotericin B as antifungal agent exhibited promising activity as compared to the references. The structures of the synthesized compounds were confirmed on the basis of their elemental analyses as well as spectral data (IR, MS and 1H NMR).

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Preparation and evaluation of antibacterial herbal mouthwash against oral pathogens

Cited by 15 publications

References 0 publications

Synthesis and evaluation of in vitro biological activity of new series of quinazolinone and benzoxazinone derivatives

Synthesis and evaluation of in vitro biological activity of new series of quinazolinone and benzoxazinone derivatives

Effect of clove mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial

Synthesis and evaluation of antibacterial and antifungal activity of new series of thiadiazoloquinazolinone derivatives.

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