Preparation and Evaluation of Chitosan Microcapsules Containing Rifampicin

Abstract

The present investigation was designed to prepare chitosan microcapsules and evaluate the in-vitro release pattern of the drug rifampicin. The microcapsules were formulated by glutaraldehyde cross-linking method using various core:coat ratios. The prepared microcapsules were evaluated for SEM analysis, sieve analysis, drug content, encapsulation efficiency, swelling studies, in-vitro and mucoadhesion test, and were compared with pure drug. The microcapsules obtained were spherical, discrete, free flowing and exhibited a slow and sustained release over a period of 12 hrs. The release depended on core:coat ratio and size of microcapsules. In-vitro release studies were carried out in pH 1.2 and pH 7.4 and 60.20%, 43.25% and 39.63% of drug was released from microcapsules having 1:1, 1:2, and 1:3 core:coat ratios respectively after 12 hrs. Drug release was found to be diffusion controlled and followed first order kinetics.

Encapsulation of Antitubercular Drugs by Biopolymers and Polyelectrolyte Multilayers

“…Recently, the possibilities of different drug delivery systems usage (DDS) for antituberculosis drugs has been studied more: polymeric composites, microparticles, nanoparticles, liposomes, the hollow and filled capsules [2][3][4][5][6][7][8][9][10][11][12]. As a model of antituberculosis drug rifampicin has been more studied [5][6][7][8][11][12].…”

“…The authors [11] have prepared the chitosan-alginate microcapsules containing antituberculosis drugs rifampicin, isoniazide or pyrazinamide in the ratio drug: alginate: chitosan 1:2:2. They have shown that drug release from microcapsules happens within 72 hours.…”

“…В последнее время изучены возмож-ности использования различных систем доставки для создания противотуберку-лезных лекарственных препаратов: по-лимерные композиты, микрочастицы, наночастицы, липосомы, заполненные и полые капсулы [2][3][4][5][6][7][8][9][10][11][12]. В большинстве случаев в качестве модели рассматривал-ся рифампицин [5][6][7][8][11][12].…”

“…Авторами [11] были получены хитозан-альгинатные микрокапсулы, со-держащие противотуберкулезные лекар-ственные препараты: рифампицин, изо-ниазид или пиразинамид в соотношении препарат : альгинат : хитозан (1:2:2). По-казано, что препараты высвобождаются из таких микрокапсул в течение 72 часов.…”