Preparation and evaluation of conjugate nanogels of glycyl-prednisolone with natural anionic polysaccharides as anti-arthritic delivery systems

Mizuno, Kohei; Ikeuchi-Takahashi, Yuri; Hattori, Yoshiyuki; Onishi, Hiraku

doi:10.1080/10717544.2020.1865478

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…After 7 or 24 h the concentration of the drug in inflamed joints was higher for the loaded NGs in comparison to the drug alone. In addition, in arthritic rats the NGs localized preferably to the joints than to the plasma in contrast to normal rats [81].…”

Section: Bone Marrow Mesenchymal Stem Cellsmentioning

confidence: 77%

“…The NGs were tested for their Conjugates between polysaccharides such as CS and prednisolone with glycin linkers are promising for applications in treatments of ulcerative colitis [73] and rheumatoid arthritis [74]. Very recently, Alg-glycyl-prednisolone conjugate NGs have been synthesized in order to overcome the negative effects of high doses of the anti-inflammatory drug [81]. The hydrophobicity of the covalently bonded drug on the polysaccharide backbone led to the self-assembly into NGs in aqueous media.…”

Section: Bone Marrow Mesenchymal Stem Cellsmentioning

confidence: 99%

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Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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Polysaccharides are natural polymers with hydrophilic, biocompatible and biodegradable characteristics and have many opportunities in the food and pharmaceutical sectors. This review focuses on the field of nano and microstructures whose internal structure is based on networked polysaccharide chains in 3D i.e., polysaccharide nanogels (NGs) and microgels (MGs). As it is observed the number of articles on NGs and MGs in peer reviewed scientific journals has been increasing over the last two decades. At the same time, the relative contribution of polysaccharides in this field is gaining place. This review focuses on the different applied methods for the fabrication of a variety of polysaccharide-based NGs and MGs and aims to highlight the recent advances on the subject and present their potentials and properties with regards to their integration in aspects of medicinal and food sciences. The presentation of the recent advances in the application of polysaccharide NGs and MGs is divided in materials with potential as emulsion stabilizers and materials with potential as carriers of bioactives. For applications in the medical sector the division is based on the fabrication processes and includes self-assembled, electrostatically complexed/ionically crosslinked and chemically crosslinked NGs and MGs. It is concluded that many advances are expected in the application of these polysaccharide-based materials and in particular as nutrient-loaded emulsion stabilizers, viscosity modifiers and co-assembled structures in combination with proteins.

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Section: Bone Marrow Mesenchymal Stem Cellsmentioning

confidence: 77%

Section: Bone Marrow Mesenchymal Stem Cellsmentioning

confidence: 99%

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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“…Similarly, HA was conjugated with prednisolone (PD) via a glycyl linker (HA‐glycyl‐PD), and due to the hydrophobic nature of PD molecules, the HA‐glycyl‐PD conjugates further afforded a nanogels (NGs) structure in water (HA‐GP‐NG) for the targeted treatment of osteoarthritis. [ 68 ] With size distributions around 300 to 400 nm, HA‐GP‐NG displayed negative zeta potentials with different drug contents. Furthermore, NGs showed prolonged retention in the circulation resulting in the enhanced distribution to the arthritic sites.…”

Section: Polysaccharide‐derived Delivery Systems For Inflammation Targetingmentioning

confidence: 99%

Natural Glycan Derived Biomaterials for Inflammation Targeted Drug Delivery

Niu

Xue

2021

Macromolecular Bioscience

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Inflammation is closely related to a variety of fatal or chronic diseases. Hence, targeting inflammation provides an alternative approach to improve the therapeutic outcome of diseases such as solid tumors, neurological diseases, and metabolic diseases. Polysaccharides are natural components with immune regulation, anti‐virus, anti‐cancer, anti‐inflammation, and anti‐oxidation activities. Herein, this review highlights recent progress in the polysaccharide‐based drug delivery systems for achieving inflammation targeting and its related disease treatment. Moreover, the chemical modification and the construction of polysaccharide materials for drug delivery are discussed in detail.

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