Preparation and Evaluation of Diclofenac Sodium Tablet Coated with Polyelectrolyte Multilayer Film Using Hypromellose Acetate Succinate and Polymethacrylates for pH-Dependent, Modified Release Drug Delivery

Jeganathan, Balamurugan; Prakya, Vijayalakshmi; Deshmukh, Abhijit M

doi:10.1208/s12249-015-0385-y

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…However, there are difficulties in quantitively controlling and prolonging the release of analgesic drug molecules such as lidocaine (LID) and diclofenac (DCF), when they are employed without any supporting matrices. Several attempts have been made to incorporate LID and DCF into nanoscale multi-layered thin films for controlling their loading capacity and release profiles (Loo et al, 2010; Jeganathan et al, 2016). LID is among the most widely used local anesthetics due to its rapid action (the effect is noticed immediately), making it suitable to alleviate the pain, caused by dressing change (Zhao et al, 2018), while DCF is a long lasting non-steroidal anti-inflammatory drug, which can provide a longer-lasting pain reduction, caused by the injury itself (Altman et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

et al. 2019

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Chronic wounds not only lower the quality of patient's life significantly, but also present a huge financial burden for the healthcare systems around the world. Treatment of larger wounds often requires the use of more complex materials, which can ensure a successful renewal or replacement of damaged or destroyed tissues. Despite a range of advanced wound dressings that can facilitate wound healing, there are still no clinically used dressings for effective local pain management. Herein, alginate (ALG) and carboxymethyl cellulose (CMC), two of the most commonly used materials in the field of chronic wound care, and combination of ALG-CMC were used to create a model wound dressing system in the form of multi-layered thin solid films using the spin-assisted layer-by-layer (LBL) coating technique. The latter multi-layer system was used to incorporate and study the release kinetics of analgesic drugs such as diclofenac and lidocaine at physiological conditions. The wettability, morphology, physicochemical and surface properties of the coated films were evaluated using different surface sensitive analytical tools. The influence of in situ incorporated drug molecules on the surface properties (e.g., roughness) and on the proliferation of human skin cells (keratinocytes and skin fibroblasts) was further evaluated. The results obtained from this preliminary study should be considered as the basis for the development “real” wound dressing materials and for 3D bio-printing applications.

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Section: Introductionmentioning

confidence: 99%

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

et al. 2019

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“…Samples with the precipitated PECs were subsequently homogenized at 5000 rpm for 1 min to unify the particle size, then transferred to the sample cell for measurements. All results were performed within 15 min of PEC formation [ 8 , 23 , 46 , 47 ]. To recognize the potential impact of pH on the PEC formation process, the pH of the obtained dispersions was also recorded [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Optimization of Multilayer Films Composed of Chitosan and Low-Methoxy Amidated Pectin as Multifunctional Biomaterials for Drug Delivery

Potaś

Wilczewska

Misiak

et al. 2022

IJMS

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Polyelectrolyte multilayers (PEMs) based on polyelectrolyte complex (PEC) structures are recognized as interesting materials for manufacturing functionalized coatings or drug delivery platforms. Difficulties in homogeneous PEC system development generated the idea of chitosan (CS)/low-methoxy amidated pectin (LM PC) multilayer film optimization with regard to the selected variables: the polymer ratio, PC type, and order of polymer mixing. Films were formulated by solvent casting method and then tested to characterize CS/LM PC PECs, using thermal analysis, Fourier transform infrared spectroscopy (FTIR), turbidity, and zeta potential measurements. The internal structure of the films was visualized by using scanning electron microscopy. Analysis of the mechanical and swelling properties enabled us to select the most promising formulations with high uniformity and mechanical strength. Films with confirmed multilayer architecture were indicated as a promising material for the multifunctional systems development for buccal drug delivery. They were also characterized by improved thermal stability as compared to the single polymers and their physical mixtures, most probably as a result of the CS–LM PC interactions. This also might indicate the potential protective effect on the active substances being incorporated in the PEC-based films.

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“…The importance of multilayer systems in controlled drug delivery was highlighted in the study on the utilization of cationic Eudragit E ® and anionic hypromellose acetate succinate (HPMCAS) PEMs in bi- and triple-layer coatings of colon-specific tablets with diclofenac sodium, by Jeganathan et al [ 43 ] ( Figure 4 ). The cores of the tablets were coated in a perforated pan coater using a 10% ( w / v ) HPMCAS solution in acetone and a 10% Eudragit E ® solution in isopropyl alcohol.…”

Section: Applicability Of Pemsmentioning

confidence: 99%

The Potential of Polyelectrolyte Multilayer Films as Drug Delivery Materials

Potaś

Winnicka

2022

IJMS

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Polyelectrolyte multilayers (PEMs) represent a group of polyelectrolyte complex (PEC)–based materials widely investigated in the biomedical and pharmaceutical sciences. Despite the unflagging popularity of the aforementioned systems in tissue engineering, only a few updated scientific reports concerning PEM potential in drug administration can be found. In fact, PEM coatings are currently recognized as important tools for functionalizing implantable scaffolds; however, only a small amount of attention has been given to PEMs as drug delivery materials. Scientific reports on PEMs reveal two dominant reasons for the limited usability of multilayers in pharmaceutical technology: complex and expensive preparation techniques as well as high sensitivity of interacting polyelectrolytes to the varieties of internal and external factors. The aim of this work was to analyze the latest approaches, concerning the potential of PEMs in pharmacy, chemical technology, and (primarily) tissue engineering, with special attention given to possible polymer combinations, technological parameters, and physicochemical characteristics, such as hydrophilicity, adhesive and swelling properties, and internal/external structures of the systems formed. Careful recognition of the above factors is crucial in the development of PEM-based drug delivery materials.

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Preparation and Evaluation of Diclofenac Sodium Tablet Coated with Polyelectrolyte Multilayer Film Using Hypromellose Acetate Succinate and Polymethacrylates for pH-Dependent, Modified Release Drug Delivery

Cited by 9 publications

References 24 publications

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

Polysaccharide Thin Solid Films for Analgesic Drug Delivery and Growth of Human Skin Cells

Optimization of Multilayer Films Composed of Chitosan and Low-Methoxy Amidated Pectin as Multifunctional Biomaterials for Drug Delivery

The Potential of Polyelectrolyte Multilayer Films as Drug Delivery Materials

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