Preparation and evaluation of dissolving microneedle loaded with azelaic acid for acne vulgaris therapy

Xing, Mengzhen; Zhang, Suohui; Ma, Yuning; Chen, Yingzhi; Yang, Guiqin; Zhou, Zequan; Gao, Yunhua

doi:10.1016/j.jddst.2022.103667

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…To prepare CP-DMNs, the compounds consisting of oligopeptide-1 (0.15%, w / v ), acetyl hexapeptide-8 (0.03%, w / v ), and palmitoyl pentapeptide-4 (0.03%, w / v ) were dissolved in ultrapure water to acquire an active ingredient solution. Afterwards, 7% ( w / v ) HA and 3% ( w / v ) PVP were performed as matrix materials due to their excellent needle-forming and skin compatibility [ 17 , 18 ]. The DMNs solution was made by mixing the active ingredient solution and matrix solution.…”

Section: Methodsmentioning

confidence: 99%

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Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas

et al. 2022

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Wrinkles are one of the most intuitive manifestations of skin aging. Complex polypeptide-loaded dissolving microneedles (CP-DMNs) for facial wrinkles in different areas have been developed and evaluated for the first time. In optimizing formulations, we compared the differences in CP-DMNs heights on skin insertion depth and skin repair and healing. Furthermore, systemic safety experiments were carried out to provide a reference for clinical application. On this basis, an 84-day efficacy assessment based on the improvement of facial wrinkles in different areas and a comparison between CP-DMNs vs. placebo was performed on 30 healthy subjects. As a result, DMNs with a height of 300 μm presented sufficient strength to pierce the stratum corneum with minimized skin damage. In addition, CP-DMNs possessed excellent biological safety and skin compatibility for clinical application. Compared with placebo, CP-DMNs exhibited obvious improvements in wrinkles distributed in the corners of eyes, under-eyes, and nasolabial folds. Furthermore, after using CP-DMNs for 84 days, facial wrinkles in five different areas were smoothed. In short, the complex polypeptides showed apparent anti-wrinkle efficacy with the aid of DMNs technology, and CP-DMNs seemed to work better on deeper wrinkles, such as frown lines and nasolabial folds.

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Section: Methodsmentioning

confidence: 99%

“…Cell viability was measured using a CCK-8 kit [ 18 ]. Firstly, six pieces of CP-DMNs were sterilized via exposure to UV overnight and immersed into 3 mL of DMEM and MEM/EBSS medium for 72 h (each medium containing three pieces of CP-DMNs).…”

Section: Methodsmentioning

confidence: 99%

Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas

et al. 2022

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“…Furthermore, there was no discernible variation in the levels of AZA in the rats’ plasma before and after treatment, indicating that the main site of action for AZA-DMN was local skin. Studies demonstrated that the formulation improved the permeability of AZA, and its observable antibacterial activity on Propionibacterium acnes and Staphylococcus epidermidis made AZA-loaded DMN a promising therapeutic method for acne . Monomethoxy-poly(ethylene glycol)-polycaprolactone (MPEG-PCL) nanoparticles loaded with 5-fluorouracil (5-Fu) and indocyanine green (5-ICG-MPEG-PCL) reacted with near-infrared light, and the nanoparticles were integrated with a dissolvable microneedle system (HA MN) containing hyaluronic acid to form 5-Fu-ICG-MPEG-PCL loaded microneedles (HA MN) for skin cancers and melanoma tumors.…”

Section: Other Nanocarriers For Topical Drug Deliverymentioning

confidence: 99%

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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“…acnes) in the hair follicles is the most serious culprit causing acne vulgaris. Though oral isotretinoin and antibiotics are still powerful measures for the clinical treatment of acne, serious side effects such as vomiting, teratogenesis, and drug resistance affect the choice of patients. ,, Moreover, skin topical administration is also an effective way to treat acne, but the barrier action of the cuticle of the skin makes the most topical preparations inefficient . Therefore, the development of a new drug delivery system that can avoid the systemic toxicity of oral administration while improving the efficiency of transdermal administration is of great significance for acne therapy.…”

Section: Introductionmentioning

confidence: 99%

Dissolving Hyaluronic Acid-Based Microneedles to Transdermally Deliver Eugenol Combined with Photothermal Therapy for Acne Vulgaris Treatment

Wang,

Gan,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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Preparation and evaluation of dissolving microneedle loaded with azelaic acid for acne vulgaris therapy

Cited by 15 publications

References 31 publications

Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas

Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

Dissolving Hyaluronic Acid-Based Microneedles to Transdermally Deliver Eugenol Combined with Photothermal Therapy for Acne Vulgaris Treatment

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