Preparation and evaluation of gemcitabin and cisplatin-entrapped Folate-PEGylated liposomes as targeting co-drug delivery system in cancer therapy

Goli, Pooneh Pakdaman; Torbati, Maryam Bikhof; Parivar, Kazem; Khiavi, Azim Akbarzadeh; Yousefi, Mohammad

doi:10.1016/j.jddst.2021.102756

Cited by 10 publications

(2 citation statements)

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“…PEGylation of nanoparticles can not only facilitate the passive targeting of cancer cells but also increase their hydrophilicity, avoid the immune system response, and increase the circulation time of nano-complex in body serum. [21,22,23] Moreover, in active tumor targeting, conjugating folic acid and anti-FR antibodies with nanocarriers can considerably raise the internalization efficiency of nanocarriers by cancer cells via folate receptor-mediated endocytosis. [24,25] In this strategy, the cellular uptake of nanocarriers can increase by ten-fold compared with non-targeted drug delivery systems and administration of pure chemotherapeutics.…”

Section: Introductionmentioning

confidence: 99%

“…The particle size, shape, and surface chemistry of nanoparticles can affect the efficiency of the enhanced permeability and retention (EPR) effect due to the enhanced passive drug targeting. PEGylation of nanoparticles can not only facilitate the passive targeting of cancer cells but also increase their hydrophilicity, avoid the immune system response, and increase the circulation time of nano‐complex in body serum [21,22,23] . Moreover, in active tumor targeting, conjugating folic acid and anti‐FR antibodies with nanocarriers can considerably raise the internalization efficiency of nanocarriers by cancer cells via folate receptor‐mediated endocytosis [24,25] .…”

Section: Introductionmentioning

confidence: 99%

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Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

Amraee,

Torbati,

Majd

et al. 2023

ChemistrySelect

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Graphene quantum dots (GQDs) possess potential properties for the targeted transport and tracking of anticancer medication to tumor cells. For this purpose, the synthesized GQDs were decorated with folic acid (FA) and methoxy polyethylene glycol (mPEG2000), and finally loaded with tamoxifen (TMX) drug. The synthesized nano‐drug was characterized using FTIR, XRD, UV‐Vis, PL, HRTEM, FESEM, and DLS analytical devices. Based on the obtained data, the average hydrodynamic diameter of particles dissolved in water was 294.7 nm and the size of dehydrated particles was between 53 and 210 nm. PL data showed that prepared nanoparticles have an emission wavelength of 438 nm, which is in the blue fluorescent wavelength range, thus making these nanoparticles suitable for cell imaging. The encapsulation efficiency and loading percentage of tamoxifen in nanoparticles were calculated at about 52.5 % and 30 %, respectively, and cumulative drug release reached 89 % within 42 hours. The cytotoxicity effects of nanoparticles were investigated. According to IC50 results, the targeted mPEG‐GQDs‐FA/TMX (TMX‐FPGs) nano‐drug was more toxic than free TMX on MCF‐7 cells and had reduced side effects on healthy HDF cells. TMX‐FPGs induced apoptosis cell death, significantly. The confocal imaging experiments showed that TMX‐FPGs are appropriate for monitoring and targeting MCF‐7 cells.

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