Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction

Li, Yun; Xie, Xin; Lee, Milton L.; Chen, Jiping

doi:10.1016/j.chroma.2011.09.070

Cited by 39 publications

(15 citation statements)

References 31 publications

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“…Common species investigated using this type of SPE material include; pharma compounds [120,121], PAHs [122,123], chloro-phenols [122], dyes [41], herbicides [124], metal ions [54,125] and basic compounds such as caffeine [126]. The implementation of methacrylate monoliths in microfluidic chips for on-chip SPE has also been investigated [127].…”

Section: Applications Of Methacrylate Polymer Monoliths In Separatmentioning

confidence: 99%

Methacrylate Polymer Monoliths for Separation Applications

Groarke

Brabazon

2016

Materials

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This review summarizes the development of methacrylate-based polymer monoliths for separation science applications. An introduction to monoliths is presented, followed by the preparation methods and characteristics specific to methacrylate monoliths. Both traditional chemical based syntheses and emerging additive manufacturing methods are presented along with an analysis of the different types of functional groups, which have been utilized with methacrylate monoliths. The role of methacrylate based porous materials in separation science in industrially important chemical and biological separations are discussed, with particular attention given to the most recent developments and challenges associated with these materials. While these monoliths have been shown to be useful for a wide variety of applications, there is still scope for exerting better control over the porous architectures and chemistries obtained from the different fabrication routes. Conclusions regarding this previous work are drawn and an outlook towards future challenges and potential developments in this vibrant research area are presented. Discussed in particular are the potential of additive manufacturing for the preparation of monolithic structures with pre-defined multi-scale porous morphologies and for the optimization of surface reactive chemistries.

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Section: Applications Of Methacrylate Polymer Monoliths In Separatmentioning

confidence: 99%

Methacrylate Polymer Monoliths for Separation Applications

Groarke

Brabazon

2016

Materials

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“…Large internal column diameters, which are more readily available in all column lengths, are not fully compatible with MS (mass spectrometry) and induce a high consumption of organic solvent, especially with flow rates as high as 10 mL·min −1 . Finally, monoliths made of silica possess limited chemical stability (pH range 2–8) [26, 28, 29], which, again, limits their applicability.…”

Section: Advanced Instrumentationmentioning

confidence: 99%

Analytical Methodologies for the Determination of Endocrine Disrupting Compounds in Biological and Environmental Samples

Sosa‐Ferrera

Mahugo-Santana

Santana‐Rodríguez

2013

BioMed Research International

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Endocrine-disruptor compounds (EDCs) can mimic natural hormones and produce adverse effects in the endocrine functions by interacting with estrogen receptors. EDCs include both natural and synthetic chemicals, such as hormones, personal care products, surfactants, and flame retardants, among others. EDCs are characterised by their ubiquitous presence at trace-level concentrations and their wide diversity. Since the discovery of the adverse effects of these pollutants on wildlife and human health, analytical methods have been developed for their qualitative and quantitative determination. In particular, mass-based analytical methods show excellent sensitivity and precision for their quantification. This paper reviews recently published analytical methodologies for the sample preparation and for the determination of these compounds in different environmental and biological matrices by liquid chromatography coupled with mass spectrometry. The various sample preparation techniques are compared and discussed. In addition, recent developments and advances in this field are presented.

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“…In order to control the properties of polymeric monoliths, various investigations have been carried out by different research groups [3][4][5]24,27]. By altering the polymerization time intervals, Nischang and Brüggemann [5] synthesized a series of poly(butyl methacrylate-co-ethylene dimethacrylate) [poly(BMA-co-EDMA)] monolithic stationary phases for separating small molecules such as alkylbenzenes.…”

Section: Introductionmentioning

confidence: 99%

“…Fast separation of PUHs was achieved in 5 min by applying a steep gradient (25-80% acetonitrile-water in 3 min) at a flow velocity of 5.43 mm s À1 (i.e., 16 mL min À1 ). In addition to dipole-dipole interactions [24,27], incorporating p-p interactions [28,29] between analytes and stationary phases were also employed to prepare alkyl methacrylate-based monoliths to separate relatively polar small molecules. Cheng et al [29] synthesized a series of alkyl methacrylate (C 4 -C 18 ) monoliths using divinylbezene (DVB) as the cross-linker to provide additional p-p interactions for analyzing aromatic sulfonamide antibiotics by on-line preconcentration CEC-MS. Smirnov et al [30] prepared a series of poly(DVB-co-ethylvinylbenzene-co-2-hydroxyethyl methacrylate) [poly(DVB-co-EVB-co-HEMA)] monolithic stationary phases in glass columns (3 mm i.d.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of poly(alkyl methacrylate-co-methacrylic acid-co-ethylene dimethacrylate) monolithic columns for separating polar small molecules by capillary liquid chromatography

Lin

et al. 2015

Analytica Chimica Acta

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Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction

Cited by 39 publications

References 31 publications

Methacrylate Polymer Monoliths for Separation Applications

Methacrylate Polymer Monoliths for Separation Applications

Analytical Methodologies for the Determination of Endocrine Disrupting Compounds in Biological and Environmental Samples

Preparation and evaluation of poly(alkyl methacrylate-co-methacrylic acid-co-ethylene dimethacrylate) monolithic columns for separating polar small molecules by capillary liquid chromatography

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