Preparation and evaluation of lipid polymer nanoparticles for eradicating H. pylori biofilm and impairing antibacterial resistance in vitro

Cai, Jie; Huang, Huizhi; Song, Weijuan; Hu, Haiyan; Chen, Jiesi; Zhang, Liyan; Li, Pengyu; Wu, Rui; Wu, Chuanbin

doi:10.1016/j.ijpharm.2015.09.055

Cited by 77 publications

(36 citation statements)

References 30 publications

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“…Using this one-step method, Cai et al [80] used Pylori adhesion material pectin sulfate (PECS) as the polymer and rhamnolipid as the lipid to encapsulate amoxicillin; the particle size was 200 nm. In addition, Li et al [81] employed curcumin–PLGA as the polymer, and 1,2-dipalmitoyl- sn -glycero-3-phosphocholine (DPPC) and DSPE-PEG as the lipids to entrap human fibronectin, and the particle size was ~150 nm.…”

Section: Methods For Preparing Drug Carriersmentioning

confidence: 99%

A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs

Cai

Huang³

et al. 2017

Nanomaterials

189

108

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Nanostructured lipid carriers (NLCs) are modified solid lipid nanoparticles (SLNs) that retain the characteristics of the SLN, improve drug stability and loading capacity, and prevent drug leakage. Polymer nanoparticles (PNPs) are an important component of drug delivery. These nanoparticles can effectively direct drug delivery to specific targets and improve drug stability and controlled drug release. Lipid–polymer nanoparticles (PLNs), a new type of carrier that combines liposomes and polymers, have been employed in recent years. These nanoparticles possess the complementary advantages of PNPs and liposomes. A PLN is composed of a core–shell structure; the polymer core provides a stable structure, and the phospholipid shell offers good biocompatibility. As such, the two components increase the drug encapsulation efficiency rate, facilitate surface modification, and prevent leakage of water-soluble drugs. Hence, we have reviewed the current state of development for the NLCs’, PNPs’, and PLNs’ structures, preparation, and applications over the past five years, to provide the basis for further study on a controlled release drug delivery system.

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Section: Methods For Preparing Drug Carriersmentioning

confidence: 99%

A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs

Cai

Huang³

et al. 2017

Nanomaterials

189

108

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“…Table 4 gives a summary of lipid‐based NPs for antimicrobial drug delivery. Cai et al reported a new lipid polymer nanoparticle formulation with rhamnolipid and phospholipids as the outer mixed lipids layer (RHL‐PC‐LPN) ( Figure ) . Amoxicillin (AMX) (10.2%) and an anti H. pylori adhesion material pectin sulfate (PECS) were loaded into the LPNs to facilitate the disruption of H. pylori biofilms and further enhanced their susceptibility to antibacterial agents.…”

Section: Classification Of Antimicrobial Nanoparticlesmentioning

confidence: 99%

Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens

Lakshminarayanan

Young

et al. 2018

Adv Healthcare Materials

122

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The rapid growth of harmful pathogens and their multidrug-resistance poses a severe challenge for health professionals and for the development of new healthcare products. Various strategies are exploited for the development of effective antimicrobial agents, and nanoparticles are a particularly promising class of materials in this respect. This review summarizes recent advances in antimicrobial metallic, polymeric, and lipid-based nanoparticles such as liposomes, solid lipid nanoparticles, and nanostructured lipid carriers. The latter materials in particular are engineered for antimicrobial agent delivery and act by encapsulation, receptor-based binding, and disruption of microbial adherence to cellular substrates. Potential strategies for the design of multifunctional antimicrobial nanocarriers, combining material chemistry and biological interface science, are also discussed.

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“…Additionally, the use of nanotechnology provides important improvements in the pharmacokinetics of antibiotics whose application is limited due to low solubility, poor bioavailability after oral administration, short half-life, high toxicity or instability in physiological conditions ( Figure 1) [8][9][10]. A broad spectrum of antimicrobial activity described for a variety of nanomaterials supports the idea that the employment of antibiotic-conjugated nanoformulations will provide a more efficient way to overcome the ever-growing drug resistance of pathogens [11,12].…”

Section: Introductionmentioning

confidence: 95%

“…Jamil et al demonstrated that cefazolin-loaded chitosan nanoparticles can be employed as stable and effective agents against multidrug-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa and extended spectrum beta lactamase (ESBL) positive E. coli [11]. Novel studies performed by Cai et al revealed that the treatment of H. pylori with amoxicillin and pectin sulfate-loaded lipid PNPs significantly eradicates H. pylori in the biofilm form, inhibits bacteria from adhering to gastric cells and decreases the MIC value for amoxicillin, which increases its ability to inhibit bacterial colonization despite the well-known resistance of H. pylori to antimicrobial treatment [12]. Additionally, Hussein-Al-Ali et al reported strong antimicrobial potential of streptomycin-conjugated magnetic nanoparticles coated with chitosan against drug-sensitive S. aureus and its methicillin-resistant counterpart (MRSA), which might be a promising strategy to fight drug-resistant infections, particularity those reported in the hospital environment [46].…”

Section: Recent Advances In Application Of Antibioticconjugated Nanopmentioning

confidence: 99%

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Michalak¹,

Głuszek²,

Piktel³

et al. 2016

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The increased prevalence of antibiotic-resistant pathogens requires additional efforts to develop new antimicrobial agents and alternative methods to prevent and treat infections. In response to this challenge, a variety of nanotechnology-based tools are currently being designed and thoroughly investigated. To date, a considerable number of studies have reported increased activity of antibiotic-conjugated polymeric nanoparticles against bacteria and fungi associated with various infections, including those caused by drug-resistant pathogens. Importantly, high biocompatibility of these structures coupled with enhanced biological activity and improved pharmacokinetic properties supports the potential of these nanosystems as new tools to treat infections. In this review, we summarize the synthesis of polymer-based nanoparticles and describe their mechanism of action. We also highlight the recent advances in the application of antibiotic-conjugated polymeric nanoparticles as novel antimicrobial agents. StreszczenieStale narastająca lekooporność drobnoustrojów wymusza konieczność rozwoju alternatywnych metod profilaktyki i terapii zakażeń, a także uzasadnia prace nad nowymi lekami o aktywności przeciwdrobnoustrojowej. Realizacja tego celu jest moż-liwa dzięki zastosowaniu osiągnięć z zakresu nanotechnologii. Zwiększająca się liczba doniesień literaturowych potwierdza znaczną aktywność przeciwdrobnoustrojową nanocząstek polimerowych skoniugowanych z klasycznymi antybiotykami, co może zostać wykorzystane w terapii infekcji o charakterze bakteryjnym i grzybiczym, również tych wywoływanych przez patogeny lekooporne. Wysoka biokompatybilność nanocząstek polimerowych, a także możliwość zwiększania aktywności przeciwdrobnoustrojowej i poprawy parametrów farmakokinetycznych stosowanych obecnie chemioterapeutyków, wskazuje na możliwość zastosowania nanostruktur w nowoczesnej terapii chorób infekcyjnych. W niniejszej pracy podsumowano metody syntezy nanosystemów opartych na nanocząstkach polimerowych, a także opisano mechanizm ich działania. Przedstawione zostały również najnowsze osiągnięcia w syntezie nanocząstek skoniugowanych z antybiotykami, pozwalające na ich zastosowanie w terapii infekcji o charakterze bakteryjnym i grzybiczym.

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Preparation and evaluation of lipid polymer nanoparticles for eradicating H. pylori biofilm and impairing antibacterial resistance in vitro

Cited by 77 publications

References 30 publications

A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs

A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs

Recent Advances in the Development of Antimicrobial Nanoparticles for Combating Resistant Pathogens

Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

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