The work covered in this report involves a study of the biological effects of radiation from mock plutonium power sources in dogs and a study of the possibility of using a tissue heat sink for eliminating additional endogenous heat from 30-watt plutonium power sources in calves. The work is one phase of a program designed to develop a completely implantable artificial heart .system for use in the hilman being. A total of sixty dogs have been implanted with radiation equivalent sources producing radiation fluxes similar to that of plutonium-238, but having no associated heat, at levels of from one to seventy times the radiation flux expected from a 30-watt plutonium-238 source. Results from studies lasting up to 6 years after implantation indicate that these animals, and by inference human beings, 238 may be able to tolerate the radiation flux from 30-watt Pu power sources. Results of heat dissipation studies in calves indicate that it may be possible to induce a vascularized connective tissue capsule sufficient to dissipate 30 watts of additional heat from a surface area of approximately 500 em sq., allowing a heat flux of 0.06 watts per cm sq.