Preparation and Evaluation of Meloxicam Microsponges as Transdermal Delivery System

Nief, Roaa A.; Hussein, Ahmed A.

doi:10.31351/vol23iss2pp62-74

Cited by 8 publications

(5 citation statements)

References 14 publications

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“…For both formula had better release than a pure drug; this can due to increasing drug dissolution when incorporated in Mgs which may be attributed to the fact that the reduction of drug particle size caused an increase in the surface area and consequently enhances the contact between particles and dissolution medium. The obtained results are in good accordance with Noyes-Whitney equation which states that the decrease in particle size lead to an increased dissolution rate (32) .…”

Section: In-vitro Drug Release Studysupporting

confidence: 87%

Study the Variables Affecting Formulation of Ethylcellulose-based Microsponges Loaded with Clobetasol

Saad,

Sabri

2023

IJPS

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Clobetasol propionate (CP) is a super potent corticosteroid widely used to treat various skin disorders such as atopic dermatitis and psoriasis. However, its utility for topical application is hampered due to its common side effects, such as skin atrophy, steroidal acne, hypopigmentation, and allergic contact dermatitis. Microsponge is a unique three-dimensional microstructure particle with micro and nano-meters-wide cavities, which can encapsulate both hydrophilic and lipophilic drugs providing increased efficacy and safety. The aim of the current study is to prepare and optimize clobetasol-loaded microsponges. The emulsion solvent diffusion method is used for the preparation of ethylcellulose (EC)-based microsponges. The impact of various formulation variables on microsponge's properties includes; drug: polymer ratio, polyvinyl alcohol (PVA) quantities, the volume of external phase, and stirring rates investigated. The microsponges were characterized in terms of particle size, product yield, CP entrapment %, and in-vitro drug release behavior. The results report that increasing EC concentration led to a significant increase in particle size, with a decrease in product yield and drug entrapment %. Increasing stirring speed or external aqueous volume or PVA w/v % caused a non-significant decrease in production yield and CP entrapment % but showed a significant decrease, and increase in particle size, respectively. Finally, it was concluded that the ability to use ethylcellous as a Msg polymer matrix to prepare uniform, highly porous particles was confirmed by microscope observation and compatibility with CP.

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Section: In-vitro Drug Release Studysupporting

confidence: 87%

Study the Variables Affecting Formulation of Ethylcellulose-based Microsponges Loaded with Clobetasol

Saad,

Sabri

2023

IJPS

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“…Spreadability is a physical property of effortlessly applying the formulation on the skin. A formula that spreads quickly with simple rubbing was preferred [19]. Results showed (F1 and F2) containing HPMC K4M have significant spreadability distance (p< 0.05) (5.1 ± 0.76 cm and 3.8 ± 0.76 cm) when compared to (F3 and F4) containing CA (3.4 ± 0.45 cm and 1.9 ± 0.15 cm).…”

Section: Spreadabilitymentioning

confidence: 99%

Preparation, Evaluation, and Histopathological Studies of Ondansetron-Loaded Invasomes Transdermal Gel

SALIH,

MUHAMMED

2024

jrp

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Ondansetron is a serotonin receptor antagonist for treating nausea and vomiting. Its multiple daily doses and extensive first-pass metabolism faced parenteral and oral administration challenges. The transdermal route enhances its bioavailability as it bypasses the first-pass effect. Invasome vesicles improve the skin permeation of ondansetron via its unique components, lecithin, limonene, and ethanol, which are considered efficient permeation enhancers. The current study intends to develop a gel containing ondansetron as invasomes vesicles with appropriate texture and efficient skin penetration. Two gelling agents, hydroxypropyl methylcellulose K4M and carbopol 934P, were used at two concentrations (0.5 and 1%, w/w). Formulas were evaluated regarding pH, content uniformity, viscosity, spreadability, and ex vivo permeation. The selected formula (F3), which contained ondansetron (5%, w/w) and used carbopol 934P at (0.5%, w/w), was homogeneous, with proper viscosity (21,500 ± 390 mPa.s) at rest and enough spreadability (3.4 ± 0.45 cm). The ex vivo permeation showed permeation flux (Jss) was (280.4 ± 3.5 g/cm2.h) with a shorter lag time (0.5 ± 0.1 h). Characterization studies revealed nanosized vesicles (Dav. = 202.9 ± 0.5 nm) as spherical shapes dispersed within a gel matrix. In vivo, skin irritation and histopathology studies using male Wistar albino rats demonstrated that (F3) was biocompatible, with no irritation reported for six consecutive days. In conclusion, the invasomes gel of ondansetron utilizing carbopol (0.5%, w/w) was prepared for transdermal delivery, offering effective permeation and safe application. An invasomes-loaded gel is considered a novel formulation, giving an efficient and realistic therapeutic option for treating vomiting.

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“…158 Similarly; some researchers explored the transdermal use of a microsponge delivery system for molecules like fluconazole 159 meloxicam. 160…”

Section: Microsponge For Tddmentioning

confidence: 99%

“…The same type of problems can be seen with other nano-carrier systems also due to issues that arise for skin compatibility, drug loading capacity, and long-term stability. [148][149][150][151][152][153][154][155][156][157][158][159][160][161] The problem associated with oil in the dispersion system is the toxicity of surfactants. Likewise, the limited use of microsponges is because of their complex synthetic route.…”

Section: Challenges Of Nano-carriers-based Tddmentioning

confidence: 99%

Increasing Efficiency of Transdermal Drug Delivery Systems Using Some Novel Penetration Enhancement Techniques - A Critical Review

Kumar Mahapatra,

Prasad,

Panda

et al. 2023

Int J Life Sci Pharm Res

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The transdermal route has drawn considerable attention and has emerged as a solid alternative to mimic the drawbacks of drugdelivery through the oral and parenteral routes. However, the effectiveness of TDDS is often limited by the skin's outermost layer, the stratumcorneum (SC), which acts as a barrier to drug diffusion. In addition, the drug molecule's molecular weight, hydrophilicity, and ionic nature canalso impact its transdermal delivery. Various methods have been developed to overcome these limitations to facilitate drug penetration acrossthe SC, including nano-carriers, wearable delivery systems, and combination-based approaches. The use of nano-carriers, such as dendrimers,liposomes, niosomes, and micro sponges, has shown promise in enhancing the efficacy of TDDS. Another emerging innovation for TDDS iswearable delivery systems, which offer non-invasive, convenient, and extended drug administration. Additionally, combination-based approaches,such as ultrasound and microneedle-based systems or ultrasound and electrical-based techniques, are also being investigated and are the centerof attraction in the research of TDDS approaches. This review summarizes a combination of all different novel penetration enhancementtechniques used to enhance the efficacy of transdermal drug delivery systems that were not precisely captured by other review articles. Most ofthe review articles emphasized these penetration enhancement techniques separately. However, a careful review of all the penetrationenhancement techniques in one article is missing. Thus, the purpose of this article is to comprehensively review and summarize the recentlyused penetration enhancement techniques along with the possible mechanism of action in a single article. Our primary aim is to collect relevantreviews and research articles by searching various databases to provide a comprehensive overview of the field. By providing a comprehensiveoverview of the available techniques, this review article will help students and researchers stay up-to-date with the latest developments in thefield of novel penetration enhancement techniques used to increase the efficiency of TDDS.

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Preparation and Evaluation of Meloxicam Microsponges as Transdermal Delivery System

Cited by 8 publications

References 14 publications

Study the Variables Affecting Formulation of Ethylcellulose-based Microsponges Loaded with Clobetasol

Study the Variables Affecting Formulation of Ethylcellulose-based Microsponges Loaded with Clobetasol

Preparation, Evaluation, and Histopathological Studies of Ondansetron-Loaded Invasomes Transdermal Gel

Increasing Efficiency of Transdermal Drug Delivery Systems Using Some Novel Penetration Enhancement Techniques - A Critical Review

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