Preparation and evaluation of MRI detectable poly (acrylic acid) microspheres loaded with superparamagnetic iron oxide nanoparticles for transcatheter arterial embolization

Wang, Huan; Qin, X Y; Li, Zi-Yuan; Guo, Li-Ying; Zheng, Zhuozhao; Liu, Li-Si; Fan, Tian-Yuan

doi:10.1016/j.ijpharm.2016.07.028

Cited by 15 publications

(18 citation statements)

References 40 publications

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“…The magnetic property of FNs was measured on a vibrating sample magnetometer (VSM; PPMS-9, Quantum Design, USA) with magnetic field in the range of ±6 kOe at room temperature 34…”

Section: Methodsmentioning

confidence: 99%

“…FNMs were prepared by inverse suspension polymerization method 26,34. Briefly, 40 mL of liquid paraffin containing 0.134 g of Span 80 (oil phase) was added into a three-necked flask equipped with a mechanical stirrer.…”

Section: Methodsmentioning

confidence: 99%

“…6, China) and environmental scanning electron microscope (ESEM; FEI Quanta 200F, EDAX/AME-TEK, US). The FNMs were also investigated under TEM with the operation as same as that of FNs except that the lyophilized FNMs were cut into thin slices so as to avoid obtaining dark photographs 34…”

Section: Methodsmentioning

confidence: 99%

“…Fourier transform infrared spectroscopic measurements of lyophilized FNMs as well as BMs were performed separately in the same condition as that for FNs 26,34…”

Section: Methodsmentioning

confidence: 99%

“…The lyophilized FNMs were grounded into powder and tested by XRD in the same condition as that for FNs 19,34…”

Section: Methodsmentioning

confidence: 99%

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<p>MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation</p>

Qin¹,

Liu²,

Li³

et al. 2019

IJN

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ObjectiveThe objective of this study was to develop magnetic embolic microspheres that could be visualized by clinical magnetic resonance imaging (MRI) scanners aiming to improve the efficiency and safety of embolotherapy.Methods and discussionMagnetic ferrite nanoclusters (FNs) were synthesized with microwave-assisted solvothermal method, and their morphology, particle size, crystalline structure, magnetic properties as well as T2 relaxivity were characterized to confirm the feasibility of FNs as an MRI probe. Magnetic polymer microspheres (FNMs) were then produced by inverse suspension polymerization with FNs embedded inside. The physicochemical and mechanical properties (including morphology, particle size, infrared spectra, elasticity, etc.) of FNMs were investigated, and the magnetic properties and MRI detectable properties of FNMs were also assayed by vibrating sample magnetometer and MRI scanners. Favorable biocompatibility and long-term MRI detectability of FNMs were then studied in mice by subcutaneous injection. FNMs were further used to embolize rabbits’ kidneys to evaluate the embolic property and detectability by MRI.ConclusionFNMs could serve as a promising MRI-visualized embolic material for embolotherapy in the future.

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“…The magnetic property of FNs was measured on a vibrating sample magnetometer (VSM; PPMS-9, Quantum Design, USA) with magnetic field in the range of ±6 kOe at room temperature 34…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Fourier transform infrared spectroscopic measurements of lyophilized FNMs as well as BMs were performed separately in the same condition as that for FNs 26,34…”

Section: Methodsmentioning

confidence: 99%

“…The lyophilized FNMs were grounded into powder and tested by XRD in the same condition as that for FNs 19,34…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

<p>MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation</p>

Qin¹,

Liu²,

Li³

et al. 2019

IJN

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Advances in Biomaterials and Technologies for Vascular Embolization

et al. 2019

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Minimally invasive transcatheter embolization is a common nonsurgical procedure in interventional radiology used for the deliberate occlusion of blood vessels for the treatment of diseased or injured vasculature. A wide variety of embolic agents including metallic coils, calibrated microspheres, and liquids are available for clinical practice. Additionally, advances in biomaterials, such as shapememory foams, biodegradable polymers, and in situ gelling solutions have led to the development of novel pre-clinical embolic agents. The aim here is to provide a comprehensive overview of current and emerging technologies in endovascular embolization with respect to devices, materials, mechanisms, and design guidelines. Limitations and challenges in embolic materials are also discussed to promote advancement in the field.

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Research on the Catalytic Hydrolysis of COS by Fe−Cu/AC Catalyst and Its Inactivation Mechanism at Low Temperature**

Han

Zhang

2022

ChemistrySelect

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For removing carbonyl sulfide (COS) from industrial waste gas at low temperatures, the critical approach is to prepare an efficient and cheap catalyst. In this paper, Fe/Cu modified coal‐based activated carbon (AC) was prepared by co‐precipitation method and tested for the catalytic hydrolysis of carbonyl sulfide (COS) at low temperatures in a fixed‐bed reactor. The results showed that the best mole ratio of Fe/Cu was 1 : 1 and the best content of metal oxides was 50 %. BET, XRD, XPS, FTIR, and SEM investigated the structure and surface properties. COS was hydrolyzed on Fe2O3 to produce H2S and CO2, and H2S reacted with CuO to have CuS. At the same time, H2S reacted with Fe2O3 to produce FeS and elementary sulfur. Oxidized elemental sulfur was to form sulfuric acid, which responded with Fe2O3 to form sulfates. The sulfates would be deposited on the catalysts’ surface and block the pore structure. Deactivation of metal oxides and blockage of pore structures were the main reason for catalyst deactivation.

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Preparation and evaluation of MRI detectable poly (acrylic acid) microspheres loaded with superparamagnetic iron oxide nanoparticles for transcatheter arterial embolization

Cited by 15 publications

References 40 publications

<p>MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation</p>

<p>MRI Detectable Polymer Microspheres Embedded With Magnetic Ferrite Nanoclusters For Embolization: In Vitro And In Vivo Evaluation</p>

Advances in Biomaterials and Technologies for Vascular Embolization

Research on the Catalytic Hydrolysis of COS by Fe−Cu/AC Catalyst and Its Inactivation Mechanism at Low Temperature**

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