Preparation and evaluation of novel bio-based Bis-GMA-free dental composites with low estrogenic activity

Sun, Yunfei; Zhou, Ze-Ying; Jiang, Hao; Duan, Yuting; Li, Jialin; Liu, Xiaoqiu; Liang, Hong; Zhao, Chengji

doi:10.1016/j.dental.2021.12.010

Cited by 20 publications

(9 citation statements)

References 65 publications

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“…In the past several decades, dental caries has received substantial interest in numerous studies and initiatives. Among these research studies, dental resin composite (DRC) is an effective method in repairing decayed teeth because of its excellent esthetics and convenient operation qualities [ 2 , 3 , 4 ], which enable more precise polishing and exhibit better wear resistance. Note, however, that in long-term dental resin restoration, the growing bacteria will create oral biofilms on the resin’s surface, particularly the gap formatted by polymerization shrinkage, and continuously degrade the current resin composite and dental tissue nearby, causing secondary caries and treatment failure [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Dental Resin Composite with Sr-N-Doped TiO2 and n-HA Fillers for Antibacterial and Mineralization Effects

Zhao

Zhang

Liang

et al. 2023

IJMS

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Dental caries, particularly secondary caries, which is the main contributor to dental repair failure, has been the subject of extensive research due to its biofilm-mediated, sugar-driven, multifactorial, and dynamic characteristics. The clinical utility of restorations is improved by cleaning bacteria nearby and remineralizing marginal crevices. In this study, a novel multifunctional dental resin composite (DRC) composed of Sr-N-co-doped titanium dioxide (Sr-N-TiO2) nanoparticles and nano-hydroxyapatite (n-HA) reinforcing fillers with improved antibacterial and mineralization properties is proposed. The experimental results showed that the anatase-phase Sr-N-TiO2 nanoparticles were synthesized successfully. After this, the curing depth (CD) of the DRC was measured from 4.36 ± 0.18 mm to 5.10 ± 0.19 mm, which met the clinical treatment needs. The maximum antibacterial rate against Streptococcus mutans (S. mutans) was 98.96%, showing significant inhibition effects (p < 0.0001), which was experimentally verified to be derived from reactive oxygen species (ROS). Meanwhile, the resin exhibited excellent self-remineralization behavior in an SBF solution, and the molar ratio of Ca/P was close to that of HA. Moreover, the relative growth rate (RGR) of mouse fibroblast L929 indicated a high biocompatibility, with the cytotoxicity level being 0 or I. Therefore, our research provides a suitable approach for improving the antibacterial and mineralization properties of DRCs.

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Section: Introductionmentioning

confidence: 99%

A Multifunctional Dental Resin Composite with Sr-N-Doped TiO2 and n-HA Fillers for Antibacterial and Mineralization Effects

Zhao

Zhang

Liang

et al. 2023

IJMS

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“…The condensation of creosol with formal aldehyde provided lignin-based bisphenols (Scheme C). Epoxide rings were introduced by reacting with epichlorohydrin . The product was further converted into the (meth)acrylate derivatives used as the resin matrices in dental composites with TEGDA and hybrid SiO 2 .…”

Section: Lignin-derived Photopolymersmentioning

confidence: 99%

“…Epoxide rings were introduced by reacting with epichlorohydrin. 176 The product was further converted into the (meth)acrylate derivatives used as the resin matrices in dental composites with TEGDA and hybrid SiO 2 . The monomer-based dental materials demonstrated a higher degree of conversion, lower volume shrinkage, and smaller surface roughness values compared to Bis-GMAbased materials.…”

Section: Lignin-derived Photopolymersmentioning

confidence: 99%

Renewable Photopolymers: Transformation of Biomass Resources into Value-Added Products Under Light

Lai,

Zhang,

Xiao

2023

ACS Sustainable Chem. Eng.

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Light-induced cross-linking of liquid monomers has found widespread applications in various fields, such as dentistry, coatings, tissue engineering, and 3D printing. These processes typically rely on monomers derived from petrochemicals, which are volatile in price and are becoming increasingly depleted, compelling researchers to explore alternative sources from forestry and agricultural crops. The renewability of these resources makes them a promising option for developing substitutive materials with similar or superior properties. The various structural subunits in biomass offer alternative building blocks for petroleum-based photopolymers including the double bond-containing and hydrophobic fatty acids and terpenes, hydrophilic carbohydrates and proteins, aromatic furfural compounds from carbohydrates, and phenolic moieties in lignin. They can be transformed into photopolymers by the inherent or chemically introduced photocurable bonds. This review seeks to highlight recent advancements in transforming renewable platform chemicals into photocurable systems for photopolymerization processes and examines the thermomechanical properties and applications of the resulting cured materials. Furthermore, potential issues for improvement are also identified, such as the cost-effectiveness of biomass-based photopolymers and the risk in competition with food production. The perspectives on future directions for improving the renewability in this area are also given.

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“…Children and adolescents with an ASA status >1 aged between 5 and 18 years were included. Patients had either an increased caries risk, healthy teeth but with fissures susceptible to caries, or fissures with an initial lesion limited to the enamel [1,12,18,19]. Known allergies or intolerances to methacrylates or other substances of fissure sealants or any other restorative filling materials were considered exclusion criteria [20,21].…”

Section: Inclusion Criteria and Follow-upsmentioning

confidence: 99%

“…In terms of composition, sealants have been fully-developed established products for decades, and have not undergone any substantial changes. Aimed at reducing potential toxicity, interest surrounding a Bisphenol A glycidyl methacrylate (Bis-GMA)-free dental material has, however, increased in recent years [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

3-Year Clinical Performance of a New Pit and Fissure Sealant

Schill

Gräser²,

Bücher

et al. 2022

JCM

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The aim of this 3-year, randomized clinical trial (RCT) in split-mouth design was to explore the clinical survival of a Bis-GMA-free pit and fissure sealant (Helioseal F Plus) in comparison to a control material (Helioseal F). The initial population consisted of 92 adolescents. Follow-ups took place after one year (N = 85), two years (N = 82) and three years (N = 76) after application. At each examination, sealant retention and the presence of caries were recorded. The statistical analysis included the calculation of Kaplan–Meier survival curves, log-rank tests and a Cox proportional hazard regression model. No adverse events were documented. The proportion of completely intact sealants and those with minimal loss was almost identical in both groups, at 84.3% (Helioseal F; 113/134) and 81.7% (Helioseal F Plus; 107/131) after three years of observation. The regression analysis revealed an operator dependency, but no significant differences were found between the materials, the study centers, the chosen isolation technique, patient age or sex. After 3 years, 91.7% and 100.0% of all molars were free of non-cavitated carious lesions or carious cavities, respectively. It can be concluded that the new fissure sealing material can be considered as at least equivalent in terms of survival and retention behavior compared to the predecessor material.

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Preparation and evaluation of novel bio-based Bis-GMA-free dental composites with low estrogenic activity

Cited by 20 publications

References 65 publications

A Multifunctional Dental Resin Composite with Sr-N-Doped TiO2 and n-HA Fillers for Antibacterial and Mineralization Effects

A Multifunctional Dental Resin Composite with Sr-N-Doped TiO2 and n-HA Fillers for Antibacterial and Mineralization Effects

Renewable Photopolymers: Transformation of Biomass Resources into Value-Added Products Under Light

3-Year Clinical Performance of a New Pit and Fissure Sealant

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