Preparation and Evaluation of Polyherbal Periodontal Gel for Treatment of Periodontitis

Abstract

Periodontal disease is one of the most important concerns for dentists and patients. The study aimed to create a topical polyherbal gel using ethanolic extract and to evaluate polyherbal gel. Ethanolic extract of Curcuma longa rhizomes, chamomile powder from Matricaria chamomilla, and clove oil were obtained and used to prepare different formulations of polyherbal gels using hydroxypropyl methylcellulose (HPMC) and other excipients. The prepared gel formulations were studied for pH, viscosity and spreadability evaluation. The pH was observed to be in between 6 to 7 and had ideal viscosity and spreadability range. The drug content and in-vitro drug release profile were evaluated and plotted to identify optimized gel formulations among all prepared formulations. The optimized polyherbal formulation, F2, was applied to field emission scanning electron microscopy (FESEM). The antimicrobial evaluation showed that the prepared formulations are effective in inhibiting microbial growth and effective in periodontal care.