Preparation and evaluation of radioiodinated thermoresponsive polymer based on poly(<i>N</i>‐isopropyl acrylamide) for radiotherapy

Karir, T.; Sarma, Haladhar Dev; Samuel, Grace; Hassan, P. A.; Padmanabhan, Dileep; Venkatesh, Meera

doi:10.1002/app.39235

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…34 The strong bands at 1261 and 802 cm 21 were attributed to the CAOAC stretching vibrations in epoxy group, 35,36 and the strong bands at 1095 and 1022 cm 21 were assigned to the CAO stretching vibrations. [37][38][39] These indicated that there was epoxy sizing agent on CF. As shown in FESEM images of untreated CF and acetone-treated CF, CF became smooth after treated by acetone.…”

Section: Resultsmentioning

confidence: 99%

Growth of silver nanowires on carbon fiber to produce hybrid/waterborne polyurethane composites with improved electrical properties

Wang

et al. 2015

J of Applied Polymer Sci

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One dimensional silver nanowires (AgNWs) were grown on carbon fiber (CF) by a facile polyol method. Fourier transform infrared spectrometer (FTIR), laser Raman spectrometer (Raman), field-emission scanning electron microscopy (FESEM), X ray diffraction instrument (XRD), energy dispersive spectrometer (EDS), and X-ray photoelectron spectrometer (XPS) were carried out to reveal the structure, morphology, and formation mechanism of the CF-AgNWs. It was found that AgNO 3 concentration of 1.5 mM, reaction temperature of 1608C, and reaction time of 120 min were appropriate conditions for growth of AgNWs on CF. Moreover, a mechanism was suggested that the cysteamine on CF acted as nucleation centers for growth of silver nanoparticles and then small sized silver nanoparticles reduced from silver nitrate were grown on CF via the silver bonding to sulfur. Through an Ostwald ripening process, small sized silver nanoparticles were grown into larger particles. With the assistance of polyvinylpyrolidone (PVP), these larger particles were directed to grow in a definite direction to form nanowires. It was found that the resistance of CFAgNWs was decreased to 19.5 X, compared with that of CF (102.6 X) with the same quality. Thus, the CF-AgNWs was added into waterborne polyurethane (WPU) to improve the electrical and dielectric properties of WPU. Results showed the WPU/CF-AgNWs composite presented a lower percolation threshold than WPU/CF composite. When the content was 2.5 wt %, the volume resistivity of the WPU/CF-AgNWs (1.90 3 10 4 X cm 21 ) was lower by approximately three orders of magnitude than that of WPU/CF (4.19 3 10 7 X cm 21 ). When the content was 2.5 wt %, the dielectric constant and dielectric loss of the WPU/CF-AgNWs were improved to 15.24 and 0.21, which were 34.5 and 40.8% higher than that of WPU/CF.

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Section: Resultsmentioning

confidence: 99%

Growth of silver nanowires on carbon fiber to produce hybrid/waterborne polyurethane composites with improved electrical properties

Wang

et al. 2015

J of Applied Polymer Sci

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“…Hydrogels based on PNIPAAm have been studied extensively for drug‐delivery applications . The release of drugs in a sustained manner is one of the most important concerns in drug‐delivery systems.…”

Section: Introductionmentioning

confidence: 99%

“…Hydrogels based on PNIPAAm have been studied extensively for drug-delivery applications. [9][10][11][12] The release of drugs in a sustained manner is one of the most important concerns in drugdelivery systems. However, hydrogels typically release drugs, especially proteins, by rapid diffusion in an initial short-lasting burst, which is followed by a slow and relatively constant release rate.…”

Section: Introductionmentioning

confidence: 99%

Novel thermosensitive hydrogel composites based on poly(d,l‐lactide‐co‐glycolide) nanoparticles embedded in poly(n‐isopropyl acrylamide) with sustained drug‐release behavior

Baghaei

Jafari

Khonakdar

et al. 2014

J of Applied Polymer Sci

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To reach sustained drug release, a new composite drug‐delivery system consisting of poly(d,l‐lactide‐co‐glycolide) (PLGA) nanoparticles (NPs) embedded in thermosensitive poly(N‐isopropyl acrylamide) (PNIPAAm) hydrogels was developed. The PNIPAAm hydrogels were synthesized by free‐radical polymerization and were crosslinked with poly(ethylene glycol) diacrylate, and the PLGA NPs were prepared by a water‐in‐oil‐in‐water double‐emulsion solvent‐evaporation method. The release behavior of the composite hydrogels loaded with albumin–fluorescein isothiocyanate conjugate was studied and compared with that of the drug‐loaded neat hydrogel and PLGA NPs. The results indicate that we could best control the release rate of the drug by loading it to the PLGA NPs and then embedding the whole system in the PNIPAAm hydrogels. The developed composite hydrogel systems showed near zero‐order drug‐release kinetics along with a reduction or omission of initial burst release. The differential scanning calorimetry results reveal that the lower critical solution temperature of the developed composite systems remained almost unchanged (<1°C increase only). Such a characteristic indicated that the thermosensitivity of the PNIPAAm hydrogel was not distinctively affected by the addition of PLGA NPs. In conclusion, an approach was demonstrated for the successful preparation of a new hybrid hydrogel system having improved drug‐release behavior with retained thermosensitivity. The developed systems have enormous potential for many biotechnological applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40625.

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Synthesis of Thermoresponsive Polymers for Drug Delivery

Mishra

Mozumdar

2014

Methods in Molecular Biology

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A protocol for synthesizing thermosensitive copolymers of N-isopropylacrylamide (NIPAM) and N-vinylpyrrolidone (VP), cross-linked with N,N'-methylene-bis-acrylamide (MBA) has been described in this chapter. The copolymers have been formed at different concentrations of NIPAM and VP and at two different temperatures (70 °C and 30 °C). The lower critical solution temperature (LCST) of the samples has been measured, and the size of the particles formed with the highest concentration of NIPAM and lowest concentration of VP (MG1 and NG1) has been measured at three different temperatures of 25 °C, 35 °C, and 37 °C. Both MG1 and NG1 showed the lowest size at 37 °C. The MG1 and NG1 samples were further characterized using TEM and SEM. The MG1 particles were subsequently used for protein drug delivery, using BSA as a model. The release profile showed the best fit with the zero-order model. Finally, cytotoxicity studies of the synthesized MG1 and NG1 particles were carried out, using in vitro MTT assay, so as to determine the overall biocompatibility of the materials.

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Preparation and evaluation of radioiodinated thermoresponsive polymer based on poly(N‐isopropyl acrylamide) for radiotherapy

Cited by 4 publications

References 36 publications

Growth of silver nanowires on carbon fiber to produce hybrid/waterborne polyurethane composites with improved electrical properties

Growth of silver nanowires on carbon fiber to produce hybrid/waterborne polyurethane composites with improved electrical properties

Novel thermosensitive hydrogel composites based on poly(d,l‐lactide‐co‐glycolide) nanoparticles embedded in poly(n‐isopropyl acrylamide) with sustained drug‐release behavior

Synthesis of Thermoresponsive Polymers for Drug Delivery

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