Preparation and evaluation of samarium (III) phosphate [153Sm] colloid (SMPC) for possible therapeutic use

Prabhakar, G.; Joshi, Sangeeta; Ranganatha, D.K.; Subramanian, Umamaheswari; Ananthakrishnan, M.; Ramamoorthy, N.

doi:10.1016/s0969-8051(00)00097-4

Cited by 12 publications

(2 citation statements)

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“…The neutral [SmCit] 0 species is more prevalent at lower pH values. (At pH = 5, 82.1% is in the form of [SmCit] 0 and at this pH forms the colloids used for radiation synovectomy [26,27], which will be irreversibly filtered by the liver if injected intravenously [28]). Although one can argue that blood plasma will buffer and adjust an injected bolus of Brought to you by | New York University Bobst Library Technical Services Authenticated Download Date | 5/28/15 3:10 PM…”

Section: Discussionmentioning

confidence: 99%

Metal-ion speciation in blood plasma incorporating the water-soluble polymer, polyethyleneimine functionalised with methylenephosphonate groups, in therapeutic radiopharmaceuticals

Jarvis¹,

Zeevaart²,

Wagener³

et al. 2002

Radiochimica Acta

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A water-soluble polymer, polyethyleneimine functionalised with methylene phosphonate groups (PEI-MP) and labelled with 99m Tc, has shown selective uptake into bone tumours. Apparent formation constants for the complexation of important blood plasma metal-ions and metal-ions of radionuclides used in therapeutic radiopharmaceuticals (excluding Tc) with PEI-MP were measured potentiometrically. These were added to the ECCLES data base in order to construct a blood plasma model for PEI-MP. From this model it could be predicted that the polymer would not deliver the therapeutic radionuclides 153 Sm, 166 Ho, 212 Pb, 213 Pb and 89 Sr to bone. This was clinically verified for 153 Sm. However good uptake of 99m Tc-PEI-MP could be demonstrated in dogs. Due to the similar chemistry of Re as compared to Tc, it can be expected that PEI-MP labelled with 186 Re or 188 Re could result in effective therapeutic radiopharmaceuticals for bone cancer.

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Section: Discussionmentioning

confidence: 99%

Metal-ion speciation in blood plasma incorporating the water-soluble polymer, polyethyleneimine functionalised with methylenephosphonate groups, in therapeutic radiopharmaceuticals

Jarvis¹,

Zeevaart²,

Wagener³

et al. 2002

Radiochimica Acta

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“…Finally, Ga radioisotopes used in nuclear medicine are 68 Ga and 67 Ga. The γ energies for 67 Ga (Eγ = 173 keV (89%) and 247 keV (95%)) are useful for SPECT imaging [26], whereas the β + energies for 68Ga (E β = 829.5 keV (1.2%) and 1899 keV (87.9%)) are suitable for PET. But, in the process of optimizing radiolabeling process, 67Ga is more convenient since its half-life of 3.2 days is much longer than the half-life of 68Ga (T 1/2 = 1.12 h).…”

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confidence: 99%

Multimodal AGuIX® Nanoparticles: Size Characterization by HF5 and Optimization of the Radiolabeling with Various SPECT/PET/Theranostic Tracers

Huclier‐Markai¹,

Thomas²,

Alliot³

et al. 2019

Int J Med Nano Res

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Diagnostics that combine imaging techniques such as PET and MRI could enhance disease detection and location if effective multimodal contrast agents can be developed. A nanoparticle called AGuIX has been developed that is comprised of gadolinium-bound by chelates and additional free chelates that can be further labelled with radioactive isotopes enabling both PET and MRI imaging. Herein, we describe the size characterization of these nanoparticles together with their size distribution, which is an important parameter for pharmacokinetics, by a hyphenated method that is hollow fiber flow field flow fractionation (HF5). Once radiolabeled, the size was determined to confirm their integrity. The average radius of these nanoparticles was about 3.5 nm and was not significantly affected by radiolabeling. The labeling of these nanoparticles with radionuclides for SPECT/PET was also evaluated (namely 64 Cu, 44 Sc and 67 Ga). Parameters such as the molar ratio, pH and temperature were optimized. For the three radionuclides considered, 60% to 100% radiolabeling yields were reached, with no further purification at this stage. High specific activities could be attainable for all percentages of free DOTA grafted at the surface of the AGuIX nanoparticles considered in this work.

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Reactor production of 32P for medical applications: an assessment of 32S(n,p)32P and 31P(n,γ)32P methods

Vimalnath

Shetty

Rajeswari

et al. 2014

J Radioanal Nucl Chem

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Preparation and evaluation of samarium (III) phosphate [153Sm] colloid (SMPC) for possible therapeutic use

Cited by 12 publications

References 1 publication

Metal-ion speciation in blood plasma incorporating the water-soluble polymer, polyethyleneimine functionalised with methylenephosphonate groups, in therapeutic radiopharmaceuticals

Metal-ion speciation in blood plasma incorporating the water-soluble polymer, polyethyleneimine functionalised with methylenephosphonate groups, in therapeutic radiopharmaceuticals

Multimodal AGuIX® Nanoparticles: Size Characterization by HF5 and Optimization of the Radiolabeling with Various SPECT/PET/Theranostic Tracers

Reactor production of 32P for medical applications: an assessment of 32S(n,p)32P and 31P(n,γ)32P methods

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