Preparation and evaluation of stavudine loaded chitosan nanoparticles

Nesalin, J. Adlin Jino; Smith, A. Anton

doi:10.1016/j.jopr.2013.02.004

Cited by 9 publications

(12 citation statements)

References 19 publications

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“…TPP solution was added with continuous stirring to produce rigid discrete microparticles. The microparticles were finally separated by centrifugation at 4000 × g for 30 min, washed several times with petroleum ether to remove the traces of oil adhering to the microparticle, and dried at room temperature. , The composition of different batches of CM of TDF is indicated in Table .…”

Section: Methodsmentioning

confidence: 99%

“…The amount of TDF in the supernatant was assayed after appropriate dilution using a UV–visible spectrophotometer at 259 nm. The EE (%) was determined in triplicate for all batches using eqs –. ,, % .25em Practical .25em Yield = Weight .25em of .25em microparticles Weight .25em of .25em drug + Weight .25em of .25em polymers × 100 % .25em Theoretical .25em Drug .25em Loading .25em ( DL ) = Weight .25em of .25em drug .25em taken Weight .25em of .25em drug .25em taken + Weight .25em of .25em polymers .25em taken × 100 % .25em Practical .25em Drug .25em Loading .25em ( DL ) = Weight .25em of .25em drug‐loaded .25em into .25em microparticles Weight .25em of .25em microparticles × 100 % EE = % Practical .25em DL % Theoretical .25em DL × 100 …”

Section: Methodsmentioning

confidence: 99%

“…This was further confirmed from the Korsmeyer-Peppas model, where n < 0.50and approximates to Fickian diffusion release mechanism. 33,50,51,79 Therefore, among all the formulations, formulation ECH-4 approximates better sustained release of TDF from the CM matrix.…”

Section: Ftir Analysismentioning

confidence: 99%

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Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Avlani,

Kumar,

H.N

2023

Mol. Pharmaceutics

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Tenofovir disoproxil fumarate (TDF)-loaded bioadhesive chitosan microparticles (CM) were developed by an emulsification internal gelation technique. Among different batches produced, ECH-4 was found to display a high % entrapment efficiency (68.93 ± 1.76%) and sustained drug release of 88.05 ± 0.38% at 24 h. Solid state characterization of ECH-4 employing DSC and PXRD indicated that the TDF existed in an amorphous state as a solid−solid solution in chitosan. Scanning electron microscopy revealed CM of ECH-4 was spherical in shape with a rough surface topography. Laser scattering analysis using Malvern Master sizer indicated that particle size of ECH-4 was in the range of 0.52 ± 0.10 μm to 284.79 ± 21.42 μm with a surface-mean diameter of 12.41 ± 0.06 μm. Ex vivo mucoadhesion studies using rabbit mucosa as a substrate indicated that 10.34 ± 2.08% of CM of ECH-4 was retained at the end of 24 h. The microparticles of ECH-4 were incorporated into dispersible tablets (DT-TCM) intended for intravaginal administration, in view to arrest the preexposure transmission of HIV during sexual intercourse. In vitro release from the dispersible tablet (F3) into simulated vaginal fluid (pH 4.5) displayed a sustained release profile of TDF as 89.98 ± 1.61% of TDF was released at 24 h. The in vitro dissolution profile of the DT-TCM was found to be similar to that of TDF loaded CM with the values of f 1 (difference factor) and f 2 (similarity factor) being 1.52 and 78.02, respectively. Therefore, DT-TCM would be a promising novel drug delivery platform for pre-exposure prophylaxis against HIV.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Avlani,

Kumar,

H.N

2023

Mol. Pharmaceutics

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“…Drug released from chitosan nanoparticle was found to be best fitted with the Higuchi square root of time model [29,30]:…”

Section: In Vitro Drug Release Kineticmentioning

confidence: 99%

Surface charge switchable and pH-responsive chitosan/polymer core-shell composite nanoparticles for drug delivery application

Huang

Tsui

Tang

et al. 2017

Composites Part B: Engineering

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“…Several plant-based bioactive compounds are formulated into different dosage forms to overcome these drawbacks. Most of the recent studies employ nanotechnology approaches to improve the solubility, bioavailability and bioefficacy as it allows the use of biodegradable, non-toxic nanoparticles having a higher surface to volume ratio to attach or encapsulate natural plant products [12].…”

Section: Introductionmentioning

confidence: 99%

Enrichment of in Vivo Efficacy of Catechin Rich Extract With the Application of Nanotechnology

et al. 2018

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Objective: The primary goal of this study was to convert a natural catechin-rich extract into nanoparticles by using a biodegradable and non-toxic polymer Eudragit L 100 to address the various biopharmaceutical problems of catechin.Methods: Nanoparticles were prepared by emulsion solvent evaporation technique using Eudragit L 100 in increasing concentration. Optimization of processing conditions like a selection of organic solvents, diluent and surfactant concentrations, drug and polymer ratio and method of drying to increase the biological efficiency were duly attempted. Parameters such as dynamic light scattering, zeta potential, SEM and energy-dispersive X-ray spectroscopy were assessed for the evaluation of nanoparticles.Results: The entrapment efficiency was found to be between 35-45 % with methanol compared to other organic solvents. The zeta potential values of all the formulations were in the range of±30 mV to±60 mV) which confirms moderate to good stability. A rapid or ‘burst’ effect of the drug release in pH 6.8 buffer showing 92 % in the first 30 min which gradually decreased to 52 % by the end of 180 min but in the pH 7.4, the release was found to be moderate. SEM and DLS indicated particles were of spherical shape lying in a nanometer range of 100 to 200 nm with a proportional influence of polymer on the particles size.Conclusion: Nanoformulations were found to be more stable and confirmed the presence of major elements such as carbon and oxygen. The findings collectively indicate that it may be worthwhile to apply nanotechnology for the design of an advanced oral dosage form for an enhanced bioavailability and biological efficacy.

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Preparation and evaluation of stavudine loaded chitosan nanoparticles

Cited by 9 publications

References 19 publications

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Surface charge switchable and pH-responsive chitosan/polymer core-shell composite nanoparticles for drug delivery application

Enrichment of in Vivo Efficacy of Catechin Rich Extract With the Application of Nanotechnology

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