Preparation and Evaluation of Sustained Release Drug Delivery of Diltiazem Hydrochloride.

Abstract

Matrix tablets using PEC as matrix and Diltiazem HCl as a model drug were formulated by wet granulation technique. The matrix tablets were evaluated for physical properties, in vitro release and release data analysis The maximal yield was obtained when the ratio of guar gum: pectin was 3:7 (w/w).Release kinetic was evaluated by using USP XXIV dissolution apparatus type II was 89.54 %. It was concluded from the study that guar-pectin binary polymeric matrix system is an interesting alternative for preparing sustained release tablets.