Preparation and evaluation of the effect of particle size on the properties of chitosan-montmorillonite nanoparticles loaded with isoniazid

Banik, Nibedita; Hussain, Abul; Ramteke, Anand; Sharma, Hemanta Kumar; Maji, Tarun K.

doi:10.1039/c2ra20702h

Cited by 54 publications

(30 citation statements)

References 38 publications

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“…Therefore, a synergistic approach by using both physical and chemical crosslinking seems to be more viable to control the release behavior of drug. Similar approach has been reported by Maji et al There is hardly any report for synthesizing drug loaded carboxymethyl chitosan‐MMT nanoparticles by using ionic gelation method. In this paper, efforts are made to prepare isoniazid loaded carboxymethylchitosan‐MMT nanoparticles by ionic gelation method followed by crosslinking chemically with GA.…”

Section: Introductionsupporting

confidence: 57%

Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite

Banik

Ramteke

Maji

2014

Polym. Adv. Technol.

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Chitosan, a natural biopolymer, is used for drug delivery application. But its potential application is limited by its low solubility in aqueous media. The present study was designed to prepare carboxymethyl chitosan (CMC), a water soluble derivative of chitosan, and evaluate the prospective of crosslinked CMC-Montmorillonite (MMT) nanoparticles for controlled delivery of isoniazid. The nanoparticles were characterized by Fourier Transmission Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Transmission emission microscopy (TEM). The effects of MMT and glutaraldehyde on nanoparticles were assessed with regard to encapsulation efficiency, percentage swelling degree, and cumulative release. Percentage swelling degree and cumulative release were studied in pH medium 1.2 and 7.4 for 6 h. The cumulative release was studied by UV-visible spectrophotometer. Cell viability study was performed by MTT assay analysis. FTIR and NMR study indicated the successful preparation of CMC. FTIR study confirmed the interaction of MMT with CMC. The exfoliation of MMT layers and molecular level dispersion of isoniazid in CMC was examined by XRD and TEM. SEM study showed that the surface of the CMC-MMT nanoparticles was smooth compared with those of CMC nanoparticles. Swelling and release of isoniazid from the nanoparticles increased with the decrease in the MMT and glutaraldehyde content. The percentage swelling degree and cumulative release was more in pH 1.2. Cell viability study revealed that CMC was not cytotoxic, and the nanoparticles containing MMT was less cytotoxic than those of MMT free nanoparticles. CMC-MMT nanoparticles can be exploited as potential drug carrier for controlled release applications.

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Section: Introductionsupporting

confidence: 57%

Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite

Banik

Ramteke

Maji

2014

Polym. Adv. Technol.

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“…It was found that the EE of INH was superior than RF, which could be attributed to the fact that INH is more hydrophilic than RF even the same ratio of both drugs. A similar result was also observed when leucovorin and 5‐flurouracil was encapsulated into CS NPs . Furthermore, the successful encapsulation was found on by ionic interaction and hydrogen bonding.…”

Section: Resultssupporting

confidence: 88%

Phosphorylated κ‐Carrageenan‐Facilitated Chitosan Nanovehicle for Sustainable Anti‐Tuberculosis Multi Drug Delivery

et al. 2017

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Phosphorylated κ‐carrageenan has the potential to exhibit higher antioxidant activity than other polysaccharides. Low‐molecular‐weight κ‐carrageenan polysaccharides (LMW κ‐CAR) were prepared through oxidative degradation of high‐molecular‐weight κ‐carrageenan, and LMW κ‐CAR subjected into phosphorylation. Phosphorylated κ‐carrageenan (PCAR)‐chitosan (CS) nanoparticles was prepared by emulsification technique, followed by ionic gelation technique. Rifampicin (RF) and isoniazid (INH) were used as model drugs and encapsulated in CS‐PCAR nanocarriers. The encapsulation of drugs (RF and INH) in the CS‐PCAR polymeric carrier was verified by Fourier transform infrared spectroscopy (FT‐IR). The analysis of X‐ray diffraction (XRD) data demonstrated both RF and INH were loaded in the CS‐PCAR nanocarrier in an amorphous form. As observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), CS‐PCAR nanoparticles shows spherical structure with soft surface and exhibited good aggregation, whereas INH and RF loaded CS‐PCAR nanoparticles had varying shapes like hexagonal, that indicates their different compositions and structures. Encapsulation efficiency was determined by UV‐Vis, which was interrelated to the initial concentration of INH and RF. Cumulative release of RF and INH from CS‐PCAR nanoparticles was observed in in‐vitro studies. An initial, tremendous release was observed from both RF and INH drug formulated carriers, which was followed a regular prolonged releases. The outcome of the drug release was controlled by their drug quantity, indicating that the discharge could be suffered by concentration of drug. The results suggest that CS‐PCAR nanoparticles are a pretty system for simultaneous release of RF and INH in the treatment of tuberculosis.

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“…Chitosan has many advantageous biological properties in the application as a wound dressing, namely biocompatibility, biodegradability, hemostatic activity, anti-infectional activity and property to accelerate wound-healing [1][2][3][4][5][6][7]. Chitosan influence positively in to various steps of complex wound healing process.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

Archana

Singh

Dutta

et al. 2015

International Journal of Biological Macromolecules

329

134

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Preparation and evaluation of the effect of particle size on the properties of chitosan-montmorillonite nanoparticles loaded with isoniazid

Cited by 54 publications

References 38 publications

Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite

Carboxymethyl chitosan-montmorillonite nanoparticles for controlled delivery of isoniazid: evaluation of the effect of the glutaraldehyde and montmorillonite

Phosphorylated κ‐Carrageenan‐Facilitated Chitosan Nanovehicle for Sustainable Anti‐Tuberculosis Multi Drug Delivery

Chitosan-PVP-nano silver oxide wound dressing: In vitro and in vivo evaluation

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